ID   A0A1J1J0K8_9DIPT        Unreviewed;      1052 AA.
AC   A0A1J1J0K8;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=CLUMA_CG017469, isoform B {ECO:0000313|EMBL:CRL04377.1};
GN   ORFNames=CLUMA_CG017469 {ECO:0000313|EMBL:CRL04377.1};
OS   Clunio marinus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC   Clunio.
OX   NCBI_TaxID=568069 {ECO:0000313|EMBL:CRL04377.1, ECO:0000313|Proteomes:UP000183832};
RN   [1] {ECO:0000313|EMBL:CRL04377.1, ECO:0000313|Proteomes:UP000183832}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Syromyatnikov M.Y., Popov V.N.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the BRAG family.
CC       {ECO:0000256|ARBA:ARBA00006248}.
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DR   EMBL; CVRI01000063; CRL04377.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J1J0K8; -.
DR   STRING; 568069.A0A1J1J0K8; -.
DR   OrthoDB; 204547at2759; -.
DR   Proteomes; UP000183832; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13318; PH_IQSEC; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR033742; IQSEC_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663:SF342; FI21420P1; 1.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF16453; IQ_SEC7_PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000183832};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           34..1052
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012023531"
FT   DOMAIN          526..712
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          386..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..437
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..484
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1052 AA;  120007 MW;  12E27CF85F0A995B CRC64;
     MYIVQRIEFR RFAGNIWILF RQFFLAFCLP QKADRPQCTG NINTSTEKYQ FESSHSSYTT
     GHQHVIDNNL DGYDIEDEIL CDHIDDDESN HSYVYLQQQQ HYTPPPVEFQ EPATPQHQTL
     IKKGSIMRNN PELMKRNRQN NSSYELSQDL LDKQIELLER KYGGVRARKA AVCIQRAFRH
     YKMVKKFASI TAMAKADKRI SNRCSMQSLI SVGEYEPEGG NQSGQKVCAI ISATPPGQRT
     SITANRAVSF RERRNVLDSN FNQVATPAVK RQPLSQNNFQ QLPSQANPQH SHAYVNLLHQ
     QDQQYNNYQQ SYHSHSNINN NNNFAISGSN NSSLNSSSLH HFDVSHLNSS AGSAGVNTSM
     NTSWNSYNNS PNASLYAQQQ TYYIRPRTSS ASKKVPPEVP KRTSSIQNPP PKYQQSHMHH
     HMKHHHHHHH HHHHQAQQFV QTKSGGGNQY FKTENGNHSS PSSIDSLSLS SNSPVPPGHW
     QQQASIEQQQ ILHQQYLIEQ KQLQQQLIIQ QQNEIQLQAK LSETIRKRQY RIGLNLFNKK
     PEKGIAYLMH KNFLENSPHA VAKFLISRKG LSRQMIGEYL GNLQQAFNMA VLEYFAEEMD
     FSGLAIDVAL KKFQGYFRMP GEAQKIERLM EVFSHRYGVC NPDVIEKLRT PDTIFVLAFA
     IIMLNTDLHT PNIKADRRMK PDDFIKNLRG IDDCMDIDKN LLSGIYERIK ETEFKTASDH
     VTQVMKVQKT IVGKKLNLAL PHRRLVCYCR LYEIPDINKK ERQGLHQREV FLFNDLLVVT
     KIFTKKKASV TYTFRNSFPL CGLVVTLLDV PNYPFCIRLS QKVDGKVLAT FNARNEHDRC
     KFADDLRESI AEMDEMETIR IEMELERQLK ATRCVGNGMN NNVENRDSGV VGDIESIQFT
     SSKSFEAKSS SNHDIQSGQL KRGGALSNSL LDIHDQFGND CRQRRGSVGS LDSGMSISFQ
     SSTTNNGAVG GKQNNVENAA TVYVTSAQVA MAVASTNIQR QPMTGQMMVQ VPPLLPNSAL
     YQYNNDHMIN IHEIYDEHHR IHPEQTGRST DV
//