ID A0A1J1J845_9DIPT Unreviewed; 1214 AA.
AC A0A1J1J845;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=putative Insulin-like receptor {ECO:0000313|EMBL:CRL08130.1};
GN ORFNames=CLUMA_CG020870 {ECO:0000313|EMBL:CRL08130.1};
OS Clunio marinus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Clunio.
OX NCBI_TaxID=568069 {ECO:0000313|EMBL:CRL08130.1, ECO:0000313|Proteomes:UP000183832};
RN [1] {ECO:0000313|EMBL:CRL08130.1, ECO:0000313|Proteomes:UP000183832}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; CVRI01000074; CRL08130.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J1J845; -.
DR STRING; 568069.A0A1J1J845; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000183832; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR GO; GO:0000003; P:reproduction; IEA:UniProt.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00064; FU; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF525; INSULIN-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000183832};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 984..1006
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 532..644
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 880..979
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 882..1153
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 1214 AA; 139164 MW; A90258CFD249FF4A CRC64;
MRTENNFDQR RKNNNQHLPK DTLNIFKFLF LVLWIETPIV LGYRNFTTIE PDLMVLSMEK
ITAPVHQPFN GSGICGTVNV RFRIEDMEKY RGCRVIEGSA SIILLDDSSE NDFVNYSFPE
LTEITGFLML YRVGGVKSLS HFFPNLAVIR GRDLFKDYSL IIYEVNDLEE IGLFNLQTIE
RGNVRIEKND ILCFADRIDW TLIAGPGEHY IAKNQLPAYC PVCPYEKEDL QCPRTTSNDP
KAGTLCWNQK HCQMVCKCNG GVCNSKGKCC DPKCIGGCDN NNVKKCIACK RLAVEIDDEI
RCQDNCPEGK FEYMERRCLT RQQCFSLNNF EKYAENVSPY IPFNGTCMRG CPPTYVDFKN
QTDCKSCGSE CQRRCQAKII DSIAAAQSLK GCAIIDGPLE IRLRRSSSKS LETATNVVKE
LENSLSEIVE IQDYLKIARS YPIMSLSFLK NLKVIKGKRL ESNKYSVVLW DNQNLQELWN
QTVSVENGKL FFHFNPLLCF FKIEKVTENP SQIENYDMAK MSNGDKTTCN VMTLGVKVVE
TYSQAALLQW SPLKLGDERA LLGYGVLYIP APFNNVTIWG GRDACNDGWF IDDVNDFTTN
DSISYPLTKL EPYTQYAFYV KAYTLATEKI GAQSDIHYFR TSPGQPQAVT KLKAVPKSSS
SIILSWEPPR KVNGKLQSYI IRAKIIEKND QILEQRDYCL QPFERSETII KTDSKPPDRP
KPSLIEFIGP CDCNICIQTC QKAEEDDEDR QSSVDFEDEI QNYVYVKTEP ETVSEMREKR
RARRQAEFPE DLDKEIARRR ELETESTKTE DGKYRTFYQE INDTRQTTFE LSDLRHYSNY
QFFLKACREK DSDDRSDENC GPEAQISAIT LKEEKNDVIP RFDVVAVPGN GSLGQIKATW
EPPPNPNGLL LSYTIRYKKN DLEHTKWESS CISHKIYMNQ SFHILKSLTN GNYSIQIAAT
SMAGMGNFTQ VKYVIINEYG GFNIGFIAIS LTVVLILLFL CLIYAFKRYY LTSISNMKLI
AIVNSDYAGV DYKQDDWEVP REKVVMKGTK GLLPVRWMSP ESLKDGVFTS SSDVFSYGVV
LWEMATLASQ PYQGLSNDQV LRYVIEGGVM ERPENCPDKL YELMRRCWQH RPTARPTFMK
IIEMLLDDVN QNFRNISFYF TKEGQDTLHQ QKQGELALNI HDDVTTPLRQ DEADVSSLEG
NFFFMEEIIS DHKL
//
