ID A0A1J1LDH0_9CYAN Unreviewed; 388 AA.
AC A0A1J1LDH0;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=S-(Hydroxymethyl)glutathione dehydrogenase (Glutathione-dependent formaldehyde dehydrogenase) (Fdh) {ECO:0000313|EMBL:CUR30655.1};
DE EC=1.1.1.284 {ECO:0000313|EMBL:CUR30655.1};
GN Name=fdh {ECO:0000313|EMBL:CUR30655.1};
GN ORFNames=PL9214290245 {ECO:0000313|EMBL:CUR30655.1};
OS Planktothrix tepida PCC 9214.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Microcoleaceae; Planktothrix.
OX NCBI_TaxID=671072 {ECO:0000313|EMBL:CUR30655.1, ECO:0000313|Proteomes:UP000184315};
RN [1] {ECO:0000313|Proteomes:UP000184315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Regsiter A., william w.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CZDF01000132; CUR30655.1; -; Genomic_DNA.
DR RefSeq; WP_072717648.1; NZ_LN889782.1.
DR AlphaFoldDB; A0A1J1LDH0; -.
DR STRING; 671072.PL9214290245; -.
DR OrthoDB; 9769198at2; -.
DR Proteomes; UP000184315; Unassembled WGS sequence.
DR GO; GO:0106322; F:S-(hydroxymethyl)glutathione dehydrogenase NAD activity; IEA:UniProtKB-EC.
DR GO; GO:0106321; F:S-(hydroxymethyl)glutathione dehydrogenase NADP activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08283; FDH_like_1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CUR30655.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000184315};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 26..149
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 196..266
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 388 AA; 42582 MW; 616159C7FD2C94C7 CRC64;
MKAVCWHSSN DVRVDNVPDP KILNPRDAIL KITSTAICGS DLHLYDGYIP TMKSGDILGH
EFMGEVVELG SEVKNLKIGD RVVVPFTISC GHCFFCNRDL WSLCDNSNPN KWMAEKFYGH
SPSGLFGYSH LMGGYAGGQA EYVRVPFADV GPMKVPDGLT DEQVLFLTDI FPTGYMAAEN
CNIQPGDIIA IWGCGPVGQF TIRSAFMLGA ERVIAIDRFP ERLQMAKDAG AEIINYEEVD
PGEALKEMTG GRGPDACIDA VGMEAHGTDA MALYDTVKQA VRLETDRPFV LRQAIVACRK
GGTVSVPGVY GGFIDKMPMG AIVNKGLTLR SGQTHVHKYL HPLLERIQNG EIDPSFVITH
KLPLEDAPKA YKIFRDKQEN CIKVVLKP
//
