ID   A0A1J1LGF4_9CYAN        Unreviewed;      1023 AA.
AC   A0A1J1LGF4;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=PL9214290673 {ECO:0000313|EMBL:CUR31082.1};
OS   Planktothrix tepida PCC 9214.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Oscillatoriales; Microcoleaceae; Planktothrix.
OX   NCBI_TaxID=671072 {ECO:0000313|EMBL:CUR31082.1, ECO:0000313|Proteomes:UP000184315};
RN   [1] {ECO:0000313|Proteomes:UP000184315}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Regsiter A., william w.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; CZDF01000132; CUR31082.1; -; Genomic_DNA.
DR   RefSeq; WP_072718004.1; NZ_LN889782.1.
DR   AlphaFoldDB; A0A1J1LGF4; -.
DR   STRING; 671072.PL9214290673; -.
DR   OrthoDB; 9758243at2; -.
DR   Proteomes; UP000184315; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   Pfam; PF18135; Type_ISP_C; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000313|EMBL:CUR31082.1};
KW   Helicase {ECO:0000313|EMBL:CUR31082.1};
KW   Hydrolase {ECO:0000313|EMBL:CUR31082.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:CUR31082.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000184315}.
FT   DOMAIN          287..474
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
FT   DOMAIN          657..999
FT                   /note="Type ISP restriction-modification enzyme LLaBIII C-
FT                   terminal specificity"
FT                   /evidence="ECO:0000259|Pfam:PF18135"
SQ   SEQUENCE   1023 AA;  119359 MW;  DC6C0DAFE4FD0133 CRC64;
     MTMLNLKPTH KPVKAYYDAL QQFAKLGVSH ELAVKDAFAD LLKACCQQFD LTLIPEKEIK
     LTTGKRIRVD GALVRDGSIR YGIWEAKDSH DKLDREVKQK FAVGYPQDNI IFQAPERAIL
     WQGGKQICDE DITKPQILVD TLKLFFEYRT PEIAQWETAA SEFRSRVKDL SGKLINLIET
     QRKTNPKFIQ AFREFTEICR QAINPNLSEA AVEEMLIQHL LTERIFRQIF NNPDFTRRNI
     IAVEIEKVIQ ALTSKSFSRE HFLGEVDYFY RALEDAAKTI NDYSDKQHFL NTVYEKFFQG
     FAVKVADIHG IVYTPQPIVN FMVKSVEDIL KKEFGKSLND KGVHILDPFL GTGNFILRVM
     QEIRKTALPY KYEQELHCNE VMLLPYYIAS MNIEHQYFEA TGGYKAFEGI CLVDTFSDQQ
     VQQLSLFTPE NTARVQRQRS SPIFVIIGNP PYNAWQVNEN DNNKNLKYEE VDRQIRETYA
     KDSKATNKSS LSDPYVKAIR WASNRIGDEG IIALVTNNSF IDALAFDGMR KHLEKDFNLI
     YLVDLGGNIR KTTDPSKSIH NVFDIKVGVS INIFIRKNRS NQSKDTKIYY ASVDEFWRKE
     EKLGYLEQSK SYSNIEWSLI EPDQKSTWLT EGLKDDFENF LPIGNKETKD KSTHESAIFR
     SYSMGVQTNR DVWVYNFDKN LLIENIKLTL QNYNHQVDQW KTKRTPKDTV DSFVIYDDTK
     IKWSSHLKEC LNSEITADFN DDKIRLSMYR PFCVQLLYFD EIFNHRRGQF PLIFPTPDTE
     KENRVIAVTN HSQIPFLVQI TNCIPSLDVG GRPGQCFPFY TYDEDGTNRK DNITDWSLEQ
     FRNYYQDQTI TKWDIFYYTY GLLHHPIYRE RYAANLKREL PRIPYAPDFR GFVNAGQQLA
     DLHLNYEKQP EYPLKFIEND EFPLDLLVDK MKLSKNKTQI IYNEFLTLSG IPPEVFEYRL
     GNRSALDWII NQYQVKIDKR SGIVNDPNRL GDEQYIMRLI SQVITVSLET VKIVNHLPDL
     GLY
//