ID   A0A1J4JC37_9EUKA        Unreviewed;       959 AA.
AC   A0A1J4JC37;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=USP domain-containing protein {ECO:0000259|PROSITE:PS50235};
GN   ORFNames=TRFO_37637 {ECO:0000313|EMBL:OHS96225.1};
OS   Tritrichomonas foetus.
OC   Eukaryota; Metamonada; Parabasalia; Tritrichomonadida; Tritrichomonadidae;
OC   Tritrichomonas.
OX   NCBI_TaxID=1144522 {ECO:0000313|EMBL:OHS96225.1, ECO:0000313|Proteomes:UP000179807};
RN   [1] {ECO:0000313|Proteomes:UP000179807}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K {ECO:0000313|Proteomes:UP000179807};
RA   Benchimol M., Almeida L.G., Vasconcelos A.T., Perreira-Neves A., Rosa I.A.,
RA   Tasca T., Bogo M.R., de Souza W.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC         and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC         residue protein attached to proteins as an intracellular targeting
CC         signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OHS96225.1}.
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DR   EMBL; MLAK01001191; OHS96225.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J4JC37; -.
DR   VEuPathDB; TrichDB:TRFO_37637; -.
DR   OrthoDB; 24284at2759; -.
DR   Proteomes; UP000179807; Unassembled WGS sequence.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR028889; USP_dom.
DR   PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR   PANTHER; PTHR24006:SF722; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48; 1.
DR   Pfam; PF00443; UCH; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000179807}.
FT   DOMAIN          149..457
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
SQ   SEQUENCE   959 AA;  110076 MW;  26343E8F9A45EF10 CRC64;
     MWPFYSRPKI PSNSPSFTFL VPPKTAGKPT FSETFSQSYS SFTAVYFYET QGLTIYLTYS
     SSLCQYDDVR YLFDFVINDE KPFTTVSSFS LNRPFISIPI SSQNLQNSNK FGKKYDIHEK
     INKNDFILSI KIRSHCLSNV CVCDNIPYVG IMNLGLTCYI AASLQYLASI TPFVSLIFRQ
     KPEPNTTSYE LQRVFGQMKS STTPLSITTF VSSFGSNLRD LIFIEQDAHE FITMLFDRLD
     TELGEEFCKK RKALFGVETM RIIQCTKIDI KSEIIEDSND IDLPVKGVHN LKRALDKIST
     KEKMTGNSKW DTGDEKYGKQ DAVLYKKYKI LPPFLMFHLM RFTYNESNFE CEEVKSSFDC
     PNEIDMSKYV IDNYTHETRY KMMGIVAHRG CLISGHYVAF ISPKVDNDRW FQFNDSTVSV
     SSLNEARATF GGGKSAIMNL FGAHNDFVAY LVGYVRYDFI EENRKNLIAP VEIAPLLSNN
     FSANILNLTK LSNQSETIHK QADDDVIDLD KTKSFSPKKP ILDTIYGKGE RIDWNEKDKT
     IFELIGIPKN SNVKIYINYP KMNSLLGPID GNKSASDFAF KGFFIQFIVT DGSINEPVFV
     YIENVLFSVD DTSTLFYKYN NDYLLVFEND FLTNDSPCVP SCSSITLISK NGITLNINEI
     KLKVMANTSY QSIQVMLAEH LNQRNTQINL KQNLKILPSR VLIYSGNKFL PPNKYKNALL
     LHKFYSLEYR ILVEPATINS MNFNVPLTLF LTDLNHVTTK KEEYWFSKDT LIQSLFQYIP
     VFFNFPKNTK FLISIQNQGI ATTILGPSPT EICHSQFVNI NDAQNDFQNV RVDLIRGFFP
     KKMAEFKEFI KQKKMLTIEV RTENLWNCSR TIGFFDVNKD STFLDIVNIV KIMDKMENIN
     IKEISVKSEN YIFFGLLVQE NANVFDSLIK ASQQTQANPR SVLNHERPVI SIKLNPKSK
//