ID A0A1J4JEP0_9EUKA Unreviewed; 986 AA.
AC A0A1J4JEP0;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN ORFNames=TRFO_36745 {ECO:0000313|EMBL:OHS97129.1};
OS Tritrichomonas foetus.
OC Eukaryota; Metamonada; Parabasalia; Tritrichomonadida; Tritrichomonadidae;
OC Tritrichomonas.
OX NCBI_TaxID=1144522 {ECO:0000313|EMBL:OHS97129.1, ECO:0000313|Proteomes:UP000179807};
RN [1] {ECO:0000313|Proteomes:UP000179807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K {ECO:0000313|Proteomes:UP000179807};
RA Benchimol M., Almeida L.G., Vasconcelos A.T., Perreira-Neves A., Rosa I.A.,
RA Tasca T., Bogo M.R., de Souza W.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHS97129.1}.
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DR EMBL; MLAK01001136; OHS97129.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J4JEP0; -.
DR VEuPathDB; TrichDB:TRFO_36745; -.
DR OrthoDB; 2898719at2759; -.
DR Proteomes; UP000179807; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF12; ADENYLATE CYCLASE TYPE 3; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000179807};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 659..714
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 802..933
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 986 AA; 113044 MW; 22AF9A838DA97F90 CRC64;
MINLFPNYLK KRILDFNGKT LINRRRERGR SASDSLHSTN DILDIDENED IGARILRKPK
LKMTLRRAVD NMKCKGKTIL IISSLIRFVF VIACCSAMIN TSTHYFRSRE GVFNIIQHVG
SLRVLIDNTL LRYCRLWVIK FGITPKRGKI LRKLDVDEMC PHYINLSEST TDYLISSALE
SFYTSEQLDE ALSSLPVKKT ANLFEQPFPF RFCFGEHNEF TEDVNFTIHH VPVYFTSLAL
KYAANQDKIP PDEWHDEFEA CEIVSNFNSI VNYLDSLSTM LLDIESKASE KFQRQAFFVY
VILAPLVFVF LLVFHYIGYY DLLKGFHQIF DALIFLPTEV YKEISKPVFL LNQEEFLDGS
QIVESQDYKR RLYLAVTIIS ILLTSATIVI FSYILCVYDK KFVYLNFWLD ASSHRGPLIL
ESVINTYFYV IYSNTKNGNS SNHADFLDHV YLAQSRLASI HHDLIWGYDN VISCNGFDPR
LDSIHFDPMC KIEDNGTGLH KGYECLSADQ LILTFSKVSV DLKKKMLDKD IKERDLLRTK
EFIHYQHVSM THLYARLMEA QEILYDGLNV QMKRLKNISL ILSVIIIIIQ CILFLIETFI
GFQLNESFQI IRILISRIPT QFILKSPTLL ELITGVEDSL KSDLLSPSKT ALKRSNKIIF
SINENLNLVT ANTTALRVFN FTEEQFYGQS IQKFVTEESY QKMKTIIGQM FRGEIDHIQR
LSFVGLSDEL KEIYNEAFLE YIESDKIVVL CSSDTTQIQH NLDEIENVQQ GIDVLMKKSI
PLPILDQYKK DVNISFSLKT AAVLSMNIHN FVEYIASMSK TQVVHDLSIV FSTFDAIIAD
HYPNLIKYKI YGTCFYVAAG LFTSDLKAAT TDIINFALEC IQSLEDINQM IDSSLYASIG
INAGGSLTAG VMGKESLLFE IVGETLTATH MLMNVTGDNK VSISQEAYSI VKYDPHFVFQ
EAGKIKLCCK SDTLQSYYDV TLSEEK
//
