ID A0A1J4K3H4_9EUKA Unreviewed; 134 AA.
AC A0A1J4K3H4;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Histone H2A {ECO:0000256|RuleBase:RU003767};
GN ORFNames=TRFO_05977 {ECO:0000313|EMBL:OHT05384.1}, TRFO_07057
GN {ECO:0000313|EMBL:OHT02631.1}, TRFO_07085
GN {ECO:0000313|EMBL:OHT02649.1}, TRFO_07327
GN {ECO:0000313|EMBL:OHT02121.1}, TRFO_11300
GN {ECO:0000313|EMBL:OHS94219.1}, TRFO_13820
GN {ECO:0000313|EMBL:OHT15804.1}, TRFO_14091
GN {ECO:0000313|EMBL:OHT15467.1}, TRFO_16713
GN {ECO:0000313|EMBL:OHT13256.1}, TRFO_17886
GN {ECO:0000313|EMBL:OHT12307.1}, TRFO_17890
GN {ECO:0000313|EMBL:OHT12310.1}, TRFO_36903
GN {ECO:0000313|EMBL:OHS96975.1}, TRFO_38560
GN {ECO:0000313|EMBL:OHS95343.1};
OS Tritrichomonas foetus.
OC Eukaryota; Metamonada; Parabasalia; Tritrichomonadida; Tritrichomonadidae;
OC Tritrichomonas.
OX NCBI_TaxID=1144522 {ECO:0000313|EMBL:OHT05384.1, ECO:0000313|Proteomes:UP000179807};
RN [1] {ECO:0000313|EMBL:ARM19781.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=5977 {ECO:0000313|EMBL:ARM19781.1};
RA Rosa I.A., Brigido M.C., Santos E.O., Almeida L.G.P., Zingalli R.B.,
RA Vasconcelos A.T.R., Souza W., Benchimol M.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OHT05384.1, ECO:0000313|Proteomes:UP000179807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K {ECO:0000313|EMBL:OHT05384.1,
RC ECO:0000313|Proteomes:UP000179807};
RA Benchimol M., Almeida L.G., Vasconcelos A.T., Perreira-Neves A., Rosa I.A.,
RA Tasca T., Bogo M.R., de Souza W.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ARM19781.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=5977 {ECO:0000313|EMBL:ARM19781.1};
RX PubMed=28369980; DOI=.1111/boc.201600050;
RA de Andrade Rosa I., Brigido M.C., de Oliveira Santos E., Gonzaga L.,
RA Zingali R.B., de Vasconcelos A.T., de Souza W., Benchimol M.;
RT "The costa of trichomonads: A complex macromolecular cytoskeleton structure
RT made of uncommon proteins.";
RL Biol. Cell 109:238-253(2017).
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA. {ECO:0000256|RuleBase:RU003767}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU003767}.
CC -!- SIMILARITY: Belongs to the histone H2A family.
CC {ECO:0000256|ARBA:ARBA00010691, ECO:0000256|RuleBase:RU003767}.
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DR EMBL; KX579547; ARM19781.1; -; Genomic_DNA.
DR EMBL; MLAK01001337; OHS94219.1; -; Genomic_DNA.
DR EMBL; MLAK01001252; OHS95343.1; -; Genomic_DNA.
DR EMBL; MLAK01001146; OHS96975.1; -; Genomic_DNA.
DR EMBL; MLAK01000882; OHT02121.1; -; Genomic_DNA.
DR EMBL; MLAK01000860; OHT02631.1; -; Genomic_DNA.
DR EMBL; MLAK01000860; OHT02649.1; -; Genomic_DNA.
DR EMBL; MLAK01000760; OHT05384.1; -; Genomic_DNA.
DR EMBL; MLAK01000566; OHT12307.1; -; Genomic_DNA.
DR EMBL; MLAK01000566; OHT12310.1; -; Genomic_DNA.
DR EMBL; MLAK01000545; OHT13256.1; -; Genomic_DNA.
DR EMBL; MLAK01000218; OHT15467.1; -; Genomic_DNA.
DR EMBL; MLAK01000186; OHT15804.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J4K3H4; -.
DR VEuPathDB; TrichDB:TRFO_05977; -.
DR VEuPathDB; TrichDB:TRFO_07057; -.
DR VEuPathDB; TrichDB:TRFO_07085; -.
DR VEuPathDB; TrichDB:TRFO_07327; -.
DR VEuPathDB; TrichDB:TRFO_11300; -.
DR VEuPathDB; TrichDB:TRFO_13820; -.
DR VEuPathDB; TrichDB:TRFO_14091; -.
DR VEuPathDB; TrichDB:TRFO_16713; -.
DR VEuPathDB; TrichDB:TRFO_17886; -.
DR VEuPathDB; TrichDB:TRFO_17890; -.
DR VEuPathDB; TrichDB:TRFO_36903; -.
DR VEuPathDB; TrichDB:TRFO_38560; -.
DR OrthoDB; 235643at2759; -.
DR Proteomes; UP000179807; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR CDD; cd00074; H2A; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR032454; Histone_H2A_C.
DR InterPro; IPR032458; Histone_H2A_CS.
DR PANTHER; PTHR23430; HISTONE H2A; 1.
DR PANTHER; PTHR23430:SF50; HISTONE H2A; 1.
DR Pfam; PF00125; Histone; 1.
DR Pfam; PF16211; Histone_H2A_C; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00414; H2A; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR PROSITE; PS00046; HISTONE_H2A; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU003767};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003767};
KW Nucleosome core {ECO:0000256|ARBA:ARBA00023269,
KW ECO:0000256|RuleBase:RU003767};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU003767};
KW Reference proteome {ECO:0000313|Proteomes:UP000179807}.
FT DOMAIN 7..97
FT /note="Histone H2A/H2B/H3"
FT /evidence="ECO:0000259|Pfam:PF00125"
FT DOMAIN 100..133
FT /note="Histone H2A C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16211"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 134 AA; 14717 MW; 620757D83E40D2B3 CRC64;
MPAKKGVKKT ATKTAVDGER QHPKTRSSRA GLQFPVGRLH RFLREGRYGE RVGAGAPVFM
AAVLEYLTVE VLELAGNAAR DNKKTRISPR HIMLAIRNDE ELNQLLSNIT IASAGVVPHI
HKVLLGTTKK GKEE
//
