ID A0A1J4K4V2_9EUKA Unreviewed; 2247 AA.
AC A0A1J4K4V2;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Serine/threonine-protein kinase TOR {ECO:0000256|RuleBase:RU364109};
DE EC=2.7.11.1 {ECO:0000256|RuleBase:RU364109};
GN ORFNames=TRFO_06182 {ECO:0000313|EMBL:OHT04748.1};
OS Tritrichomonas foetus.
OC Eukaryota; Metamonada; Parabasalia; Tritrichomonadida; Tritrichomonadidae;
OC Tritrichomonas.
OX NCBI_TaxID=1144522 {ECO:0000313|EMBL:OHT04748.1, ECO:0000313|Proteomes:UP000179807};
RN [1] {ECO:0000313|Proteomes:UP000179807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K {ECO:0000313|Proteomes:UP000179807};
RA Benchimol M., Almeida L.G., Vasconcelos A.T., Perreira-Neves A., Rosa I.A.,
RA Tasca T., Bogo M.R., de Souza W.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|RuleBase:RU364109};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|RuleBase:RU364109}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHT04748.1}.
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DR EMBL; MLAK01000782; OHT04748.1; -; Genomic_DNA.
DR VEuPathDB; TrichDB:TRFO_06182; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000179807; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05169; PIKKc_TOR; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024585; mTOR_dom.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR026683; TOR_cat.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF127; PHOSPHATIDYLINOSITOL 3-AND 4-KINASE FAMILY PROTEIN; 1.
DR Pfam; PF11865; DUF3385; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01346; DUF3385; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364109};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU364109};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364109};
KW Reference proteome {ECO:0000313|Proteomes:UP000179807};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU364109};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364109}.
FT DOMAIN 1152..1648
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1856..2179
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2215..2247
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2126..2170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2126..2144
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2247 AA; 258419 MW; 0B497397CBB2B4E9 CRC64;
MKTRNVPITH LTYKELIENA RKTREIEYSR LSTLSYEKLS NVTSQSINSI SLPRPTSDPS
QIFKISSLIY TLLKLRQDHY PKLISILNNL NTDRNEQVGI FVSYVYSKVL KHAQRGFLQQ
KLDVCLLKLQ STSNVLQTAY FLFFLAQHSP NSILLCITQF INATTKVIMH KREDVRLVGY
ETLKLYLQIL ERTGNSQYPT FPLYFFALKN LHNRQGAFLI FSSLLEYSPE SINDQAVLMD
FFIKLLPECS EDLRSLVLRN LVLLAPLQLD DFKRKYFKFV VDSLWRENNL ENADSIVSSS
LCDLIHLVPE LFESTKMNFI IIIRNLLNLA FKAPLDGGFL ILSAVVTYFP EVIQEHPIEI
ANILIQTTIC KMFIEVVPKI FYDFNCVWDK FKFYLSNKII NDPHYIENED ILNFLATCPP
LESQEVMKFL ITTLSHKNPN IRCIAPRALL AHIPYDNKKF IQEIVFRLIT ISLSDPEPKV
REMILRSFSS KCYPFLTTDP ILTCMTSLVK DEKINVSNAA IEILGNLSKL NPFDSLPTLR
SLILDALLML DSPRPLRIKE EMTRTFMTII EAAHEILPVY CPTLCLIALR QLSFTPLCEL
TYFDQSYLHK INLNITKAIG SIADRDVSLI QPHIPQFTNF FIWLLQQHGP KQLKIAVVTT
LYKIMSGTNA INEIDVAPMF SALTMIASKW NSRKLNVAVL KLIGLIGAVD QSIFSSDSTT
KKDNTIKSTN PAYPMACACR TLISVLSDDF LVIYHSEAIR SLVNIFCFDE TATVSFFNEF
MLLFLDQIRK QMTSEYIMLL TKLCSEAPRD WIMHYTNEIL ELIRELWKSP NSALTLDLIP
TIAAVFADRF SSFLPECMTF VLDTLYANRT SQYEICHKVF ATIVTIKNIS KDYHFLLFPE
IIEVATLPST LFEVRIDALI SLKVLVQQTY CIPFSAAILR CIISCIQIHD PKIQGPALMV
LYSLMIKLGD LFSFYAEQIV LTLQEHNLLT AHFLELLQSK THTYEESPFI DTEDPFTVVP
GQDSMKSKTE HVIVNEDDIK SALLFQDEET PWNWKEWYRS IIKTLLENCP SRALNSCAFL
SDVLFTTAEN LFNTSFMSIW VNLSTDTQLY ITGPLTRALL SEALPGAIRT SLVNLFDFME
RNEHPIQISR QVLCQASEKC SQFAKAFYFV LRWYEEDPHN IEAIETLIRL STSLGLKKTI
IGISKQLSSS MDFVSNPQWS EQLGQWSNAL EVYEKMPPTA ASLEGILRCL KNLQRWDEII
SKMDEFENLP TAAKHNMAAI VATALFHRQQ WSKLPPVLEY CTHESVRVLI ITALYQISQN
KRDEALQTVA QGFQLLAQNA RGVFKHDKAA LYPLLVKAQQ LQEITEIAYH KQNLEVWEKR
LSLCRQSYDV YHQIMSVHLT VFPVQETMKD SLKMIKLAMR TKDFQLFDAS LHFLFPDQQN
WPIEVSFLYA KGTWERGLQR EALTEAKEIL RKYRTDDKNL KAKIFFCCGQ WIISMTPPNK
VSNVIQNAIK FLEQSIMQGT HYYHAWHRWA WASSVIYNVD KSNLKSAFNA INGFLECVRL
KNENLLSELL QMISLFFSAN LSDDMFNATA EHIAELSDPV LLKIIPQLFI QLSHDGTRSS
AFASQITEKL LPDHFHVLLY PLILLSRNNN RAAISILETF QEENPSAVYQ SKIVSDGLLL
CSSSTFEIYN DAIVKAVRYL QKQKIDKAQK KLFDCLQNQL RPGDAQQANE LKNELESIYN
TMIYKLPQQN AFKFNYGIQP GIQNQTNYIN QMNKLNMTHQ HGKQNIRNNE KMVEMLVRQF
IKALQSIYSK IHSHIVSNRT VSMHISAPSL AQLKNSILAV PGTYSIDEQV INIFQFDPTL
DIFNSKMRPR LVAVYGSDGI AHRSLLKGRE DLRMDQRVMQ FFELINQHIF NDFTNEARSM
KITTYSITPL STNAGLIQFV DGTDTLYSLI SEYRSSHSVP VFAEQDSMET FSIKNVDLLT
PVQRLEALRF AANENKDTDL RELMWLNSPS SREWVTRSLQ FTQSCALMSI IGYVIGLGDR
HPSNLMIHRT SGNIVHIDFG DCFEVGKKRI KFPENVPFRL TRLMKRSFGP TGIDGEFRLT
CEETCKLVRS HKESIMAVLD IFLQEPLDNE DSDDDEDEAE ETETANENEN HNQTQNNSEN
EENRENRESD IETQSIEMLE MEQFEEEEVH KKGSIEESLS RILQKIIGND FDPKNELTIQ
EQVDSLIADA TNMYNLAYLY HGWTPLW
//