ID A0A1J4KBC0_9EUKA Unreviewed; 1141 AA.
AC A0A1J4KBC0;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Phospholipid-transporting ATPase {ECO:0000256|RuleBase:RU362033};
DE EC=7.6.2.1 {ECO:0000256|RuleBase:RU362033};
GN ORFNames=TRFO_04795 {ECO:0000313|EMBL:OHT08713.1};
OS Tritrichomonas foetus.
OC Eukaryota; Metamonada; Parabasalia; Tritrichomonadida; Tritrichomonadidae;
OC Tritrichomonas.
OX NCBI_TaxID=1144522 {ECO:0000313|EMBL:OHT08713.1, ECO:0000313|Proteomes:UP000179807};
RN [1] {ECO:0000313|Proteomes:UP000179807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K {ECO:0000313|Proteomes:UP000179807};
RA Benchimol M., Almeida L.G., Vasconcelos A.T., Perreira-Neves A., Rosa I.A.,
RA Tasca T., Bogo M.R., de Souza W.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate +
CC phospholipidSide 2.; EC=7.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00034036,
CC ECO:0000256|RuleBase:RU362033};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IV subfamily. {ECO:0000256|ARBA:ARBA00008109,
CC ECO:0000256|RuleBase:RU362033}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHT08713.1}.
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DR EMBL; MLAK01000660; OHT08713.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J4KBC0; -.
DR VEuPathDB; TrichDB:TRFO_04795; -.
DR OrthoDB; 275833at2759; -.
DR Proteomes; UP000179807; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR CDD; cd02073; P-type_ATPase_APLT_Dnf-like; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006539; P-type_ATPase_IV.
DR InterPro; IPR032631; P-type_ATPase_N.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01652; ATPase-Plipid; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR24092:SF150; PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362033};
KW Magnesium {ECO:0000256|RuleBase:RU362033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362033};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362033};
KW Reference proteome {ECO:0000313|Proteomes:UP000179807};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU362033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362033}.
FT TRANSMEM 52..70
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 76..93
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 268..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 313..341
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 842..860
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 917..938
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 950..968
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 980..1000
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1020..1040
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT DOMAIN 19..76
FT /note="P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16209"
FT DOMAIN 802..1047
FT /note="P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16212"
SQ SEQUENCE 1141 AA; 127700 MW; 28435790E681107A CRC64;
MSGAEEKGRS VVIHMTRNAK GKKLFMDNGI STTKYNVLTF LPKNLFEQFS RIANFYFLVT
ACLMFFPWSP LESTTALLPL AIVVLISMVR EGIEDFMRYL SDRKVNATKV DHLDGNTFKD
IEWRKVLVGD VLLIKKNEQI PADVVLLNTS EPEGIAYVDT CNLDGETNLK VRQALPQTKS
VVDAVTAAQF QSTIVCDSPN NFLYTFNGYM TIVEKNCSLT NDQVILRGCV LRNTAWAIGV
VVYTGLETKL MMNSSAARSK RSSLERGLNL KLISVFAFMI VLGIISASIG VAREKDLVNT
GKSWYLYQGK TRSAASAFFI LMFSYILLMN AMIPISLYVT LEVVRVFQAL FIAWDKGMYH
IETKTSASAR TSNLSEDLGQ IDYVFSDKTG TLTRNVMEFM KCSIGGEKYG KGITEVAYAA
AKRRGIACQP PDNVGKAFKD ERFMQLLKKD TPPIVRHFMW MLSVCHSVIP EEDSTKPYGI
AFQASSPDEG ALVGAAADFD YIFKQRGPGY VVVGHKGEDV RIEVLQTIEF TSDRKRSSVI
LRSPDTGEIV MYTKGADDCI MERLAEGAEF RAITMQHLRD FAADGLRTLC CAYKIIDEGF
YNSWAARFNE ANCLIEGREQ AVAEIADEIE RDLHLLGATA IEDKLQIGVP DAIEAILQAG
INVWIITGDK RETAINIGFA CSLLASDMTL IVLDSSDPAE IQRTIHQGLG RPGKLALIAS
GAALYYAMDE DNKDTFFALT ERCQSVICCR VSPLQKAKIV ELVRKKTGKL TLAIGDGAND
VGMILKADIG VGISGQEGRQ AVMASDYAFG QFRFLKRLLV YHGRLNLMRN VELINYSFYK
NMVYTLNQFI FGFFCNFSAM TLFDGFLYSI FNVVFTSCPP VVYAGMERDI SERRLMAFPE
LYKWDGNRKW MISYGNFWLS LSIGILHCLI SFLVPYFGMA PYVDGNGQSI GYGGFGITVY
GCVVAIVTTR IAMMTTYWTW IAHVFIWGSA CLYPLAVLIL DYSGLGKEIQ GLSVPTLGSI
QFWISIIGSV VLANLPVIAF KTVMNSLNLM TNKVMLIERT KVKAKEARRQ FELKNIETEE
QQIIGRYVDE KNETGYNFDP PVSMYRIQRF EQPSETTYYT ADAIRERIRP RMVSTFGLDQ
L
//
