ID A0A1J4KET3_9EUKA Unreviewed; 1591 AA.
AC A0A1J4KET3;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Adenylate and Guanylate cyclase catalytic domain containing protein {ECO:0000313|EMBL:OHT07893.1};
GN ORFNames=TRFO_23763 {ECO:0000313|EMBL:OHT07893.1};
OS Tritrichomonas foetus.
OC Eukaryota; Metamonada; Parabasalia; Tritrichomonadida; Tritrichomonadidae;
OC Tritrichomonas.
OX NCBI_TaxID=1144522 {ECO:0000313|EMBL:OHT07893.1, ECO:0000313|Proteomes:UP000179807};
RN [1] {ECO:0000313|Proteomes:UP000179807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K {ECO:0000313|Proteomes:UP000179807};
RA Benchimol M., Almeida L.G., Vasconcelos A.T., Perreira-Neves A., Rosa I.A.,
RA Tasca T., Bogo M.R., de Souza W.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHT07893.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MLAK01000683; OHT07893.1; -; Genomic_DNA.
DR VEuPathDB; TrichDB:TRFO_23763; -.
DR OrthoDB; 5391295at2759; -.
DR Proteomes; UP000179807; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000179807};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 116..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 875..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 974..1000
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1190..1210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1256..1339
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 1410..1542
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1591 AA; 178994 MW; 321172CE69C5E29D CRC64;
MSIPEPITGS STMLTSSSIR SLDASTRYMG MIELSPYKKT RNALFQLFDY VASESPPFFG
VHVFISIWRI IQFFGPATCA NYRFLWGEDT VMSKVWNVIS IVFHIIPVFE RESIGYIVLY
FFAGLFIVAY SLLGASAYVF SHNAKLPSFV PISISLFLAT IGYIFSPIVA ILSGEIIGRM
IDDYHTHLTP VNIVAVVLSF LIVMIYAWLY KSVYSITITF RPDSLMTVVP AVQVQNVLLM
LLITLFSGIA SQLSKIPCIV LTGVILILYG LSIPCYFSKG GYVSDNHVKS LTATAITSVL
LLLFYIICTA MEMVVSEFIL LAIVVVWIIS YVITHFIYRR YIGSNSRILD YIEDDIENFD
IVKSPHQLQN LIVIGFRLAH PICISFQLFK LGIEKYSKNV DIWLLFAKFT AIYPEETQQL
TYIAVGMSQN RLKGALAKHT QQQIQSIMRQ RETNLLPELK SKLDKVGKQV QATKHKVRYI
WDLIIQGNVK ELESVVDRAF ASIDSSEAEF LHLLRQFPNS RFVARSYARF LRDVVADHAG
HKKWAQNVSM LQRGISIAPD KAHDLGLRAF PLLPRNLENQ LASQQQTQGV LTDDTLTQEI
ETDDEQAAID AELRMSVRES INRLKIPSYK QARILRICSL ILLFVVPITA LAIYVPIYIN
SITDPLDFMY YISSLRTRLF QTAGTALHYV YENLNATNPD YGNIRTFPFD SNEMILDQEE
PPVSFGSVYA SNKQAEYLNS DLALILPELK PMMSFKSSDS TMDKVRNSIF GNTINFTTIS
DPIRLDGYDP NLDNSDDFTK YNETYSMKSA QAAIMQFMIS INDLLALEKI PEDALNRHYI
SIPINNIRAT TDKLSEALTT ICDYIVIAQD KNAKIIQISL IVIGIVVPLY YICTCILIIV
RITKEKMMIY KCLASLPKNV VSRVADSFKV LKKEEDEEMK TSRTRDEELN KQEENMLKIF
ATSSDSSRGK ATDIIIIVIT TILVAGLHIA VTCVFCLFMT NSGEKLMEAA PHVDYTTASY
TYDLASQILL MLLPGVVHPK DIYNIRHFEL QRVLLGISEW QARGVSRYRA VRYGDESLSA
VPFESLGVEL HLDETTEPCK TKQTPANDHE VYSCWPSDLL ISYCQMKLRG LLIAFTNKSQ
MFPGNNPTLK HLYHIHQVHI YENYFSPMFE NIIPMVVNIL NTQVPTITGA GYALAAAAII
IEIILLRFLI QSENRQKFAL RLLLHCPGNV VVSNSHITAL LSGNFAEKHI DATTRDAEFY
DVLVKDMPDS IITMDLEGNI QTANNATNRI YGLDIEELIG QNITTVGSGF KGENPFKDIF
EKQDKTSVEK TLIYVKENNT EIHVEVSLTV LGENLLLTTR DVTQTVMYNL LISDEKTKSD
RLLSSILPAR LVPRVQAGEK NISFAVQSVT ILFMDIVSFT PWCGSLPAAT VMKTLNLLFK
EFDALVAVHP TMTKVKCIGD CYMAAGGIFA EINQPAMHAK DVVEFGLDAI QALEELNVRI
EQDLKIRVGV NTGGPIVAGV LGTEKPTFEI LGPTINMAQQ MEHHGVPMKV HVSRAVYELI
YGGNFDVKER GEIEIKNGSV VTYVINPRKN K
//
