ID A0A1J4KGP2_9EUKA Unreviewed; 2275 AA.
AC A0A1J4KGP2;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Serine/threonine-protein kinase TOR {ECO:0000256|RuleBase:RU364109};
DE EC=2.7.11.1 {ECO:0000256|RuleBase:RU364109};
GN ORFNames=TRFO_20124 {ECO:0000313|EMBL:OHT10537.1};
OS Tritrichomonas foetus.
OC Eukaryota; Metamonada; Parabasalia; Tritrichomonadida; Tritrichomonadidae;
OC Tritrichomonas.
OX NCBI_TaxID=1144522 {ECO:0000313|EMBL:OHT10537.1, ECO:0000313|Proteomes:UP000179807};
RN [1] {ECO:0000313|Proteomes:UP000179807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K {ECO:0000313|Proteomes:UP000179807};
RA Benchimol M., Almeida L.G., Vasconcelos A.T., Perreira-Neves A., Rosa I.A.,
RA Tasca T., Bogo M.R., de Souza W.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|RuleBase:RU364109};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031, ECO:0000256|RuleBase:RU364109}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHT10537.1}.
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DR EMBL; MLAK01000608; OHT10537.1; -; Genomic_DNA.
DR VEuPathDB; TrichDB:TRFO_20124; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000179807; Unassembled WGS sequence.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd05169; PIKKc_TOR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR009076; FRB_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024585; mTOR_dom.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR026683; TOR_cat.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF127; PHOSPHATIDYLINOSITOL 3-AND 4-KINASE FAMILY PROTEIN; 1.
DR Pfam; PF11865; DUF3385; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF08771; FRB_dom; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01346; DUF3385; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364109};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU364109};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364109};
KW Reference proteome {ECO:0000313|Proteomes:UP000179807};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU364109};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364109}.
FT DOMAIN 1189..1733
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1904..2232
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2243..2275
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2275 AA; 259318 MW; E31FD99589A17EAA CRC64;
MNLKELPIPR TYPNLLKTYE AYYHGFYLDM VRMSNSNFLD YVDKYFDLLY FLAKFPGTEN
SIRAAIGVVC LHQFGYHDFK KLTAVFDRLI PQVDLEYIKF TSWCVGKLVH HPDNYEMHYA
SQLFSRVLDW TRMKGRRARP LAAAYMLESL SFNAGSIAVS FFPNFQIGIW SLVSFPSVLV
IKGVAKAIAS YTRAIIRYGR NELTEYMTFL SKVCMKLLFF DDPVRVYAAL MLFEVLVNGF
PNFFIPHLFE LLTDISDAAE GKALLVQGGA YVVISCLSQV GPSTFIDTMA DEHFAKTDEL
LLEFPFEVTR SLTMMCQFIP EFIGTKLDKM KEFAIILIDE EPDCAFKLLA AIIEYFGSKV
LPIPNEIMLK LIQLPISEDF KDFFVALMKC DTNLSNEVQQ ALNNKIIKEL KDGQKVIALN
LVSKMPKELL FEHEKLLNAI WPLTVDKDIK TRSAVPTAIF NIGRCTELVT IQSISKRFCQ
LAIYDQSVRA RCAILQALID NADESLASPD FRTFYEIFIN DDSSTVRELF YNLLVKLSRF
NPMTIMALTR CAMLDTFFII RNIPSIRKRA KTIRGLPILI KAAGRSIKAY SGGLMDIILN
ILGDYNSKAK FDNFLEEDAQ TCILIGVVDS LTLLAPMDPE IVSKHASIIV PILCDIVLTT
DHRKLRLFIF ELFYVLLTAP ASTLDYRIQI PQILTTCSQF LMTTHSRKTK MEILKVLGAI
GIVELHQRPP PKGTQTPPNM DNDLARQFFN PSRDADCSLD DSLLLSPSTS EQYFACYTAN
ALIDILKDDQ LKEFYVETIR AVVEVLKHPK MFILTYFDMF VSRLLEILEC SSDKEINLYL
PLFSNLILNS THNISPFLKR SLKLIHERFN DELSCVFIDL IIAFLTAVRD GFSPYASETI
CLLVVILDDK KTVDGLLCKK VLKAFAILGV YSADLLYLVI PQISDAIICE QTLPTVRIAA
LVTLTELAAQ VDLLPFLGPI ARSMEYCYIS FQTPKTIKAA FQLLYTILKS LGVAFLVNAQ
PLLDFLKATN NETPELKELV YQVSQGKFGD GFHPLNVNKK PDPLPKIVEK PLSADSIISK
AEDFERVGRN NERWLQSFIL CVISNSPSPS IKTCTTIATS YYPLAKKLFN CAFLSCWQKM
NLESRSSLTH VFEQLLKVSD EEDSINRSLL NVIVFMDKIE QPIGIPVFDL VSASVRSGSV
SYAIRLMMNL LDAQPDDVQV INKLIDVLVQ IGQWQNAIGV WRQSQMVSAT LSRTEVLSKL
GMWDQVEPVY REQYNNNHSF KAFSGLIESL ASLARWKQLM DFHDDFEKLK VQQKQQLAPF
FADAALHLSE WDKLHSALKY ASDDSWRCCV LSALSALHYK DFESVKRITN QTFSLLASRP
MTFWADNHQI HRETMLECQE LIEVIEMNEW LTNPRKRDDI AEVWNQRLKT ATRDFDLWFA
VLANRVRVAS VRDDALVQFF QMRSATLGKQ IHLDAFNILY PDFNLETASD AQKLCHAIAE
WNVGHNQIAL SEVKKLTTQL QGNLLMRANV FYAQWLLETE GETFTNLKDA YTYLEATVKQ
IDDSTILRYG QKTEVSKILS NTHQRNDKTN NLILPTQISE ELVMHVNQID MIRKWSDVNA
ALINFDPENK VKYVVNAITA LSRCAKLTPA FPDGVQMLNL FFENADNEII FNETNDIIKN
LPVKLLLQAS PQIEIQMSHG NMKVREFVNE LVFSLLEIHF HSLIYSLLVL KTSKNAARAK
AATSILNKWN VKYPQICSEV NLIRSALLRA AVTWNEKIAN KVSDTYDHFQ RNNMSKVIST
LKSILAMVSK PVCEMHDQFI KQHSRNLSML DQILKAYSPD NQSSVTQLTK WCKTMQDNLG
EEIKRTRIIQ LSAISRELTE KDDFILAVPG TYKPNEPINH IKYFVGQFSV YMSKQQPKDV
VIKGEDGIFY QYLLKGHEDL RLDERIMQFF RMVNSLLLKD SSLNSHPIQT VYVVPLSISH
GLVQWATGTD TLRAIIEQYR RLHSRDPLEE YMLSDDFGNG AYDFLLPIQK VQILERIFHE
IPDTDLANFF WLKAPSADVW MKQVQTYSIS IAITSIVGYI IGLGDRHPSN LLFDRNTGKV
VHIDFGDCFE RASHRKYLPE VVPFRLTRMM VKALGAGGVE GEFKTSFVNM ANLLRANKQV
LEMVLAIFVH EPLIDPDYAD DGASDNEKNY PMSPFTLKMS ALSEDTSPVN NSDDYHDTFT
SSEEMRIRIR QKITGSCCIE GTTPLSAEEQ ATKLISEATD LYTLGKMYSG WCPFW
//