ID A0A1J4KRE7_9EUKA Unreviewed; 2718 AA.
AC A0A1J4KRE7;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=TRFO_15960 {ECO:0000313|EMBL:OHT13827.1};
OS Tritrichomonas foetus.
OC Eukaryota; Metamonada; Parabasalia; Tritrichomonadida; Tritrichomonadidae;
OC Tritrichomonas.
OX NCBI_TaxID=1144522 {ECO:0000313|EMBL:OHT13827.1, ECO:0000313|Proteomes:UP000179807};
RN [1] {ECO:0000313|Proteomes:UP000179807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K {ECO:0000313|Proteomes:UP000179807};
RA Benchimol M., Almeida L.G., Vasconcelos A.T., Perreira-Neves A., Rosa I.A.,
RA Tasca T., Bogo M.R., de Souza W.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHT13827.1}.
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DR EMBL; MLAK01000469; OHT13827.1; -; Genomic_DNA.
DR VEuPathDB; TrichDB:TRFO_15960; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000179807; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR009076; FRB_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF127; PHOSPHATIDYLINOSITOL 3-AND 4-KINASE FAMILY PROTEIN; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF08771; FRB_dom; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 2.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000179807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2261..2692
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2686..2718
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1808..1831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2404..2433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1812..1831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2409..2433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2718 AA; 319556 MW; 1D1A72E4FABD1352 CRC64;
MFENVLHLIH PNPNHNYDIW KYEYHSIKNS LSPRLRILSN EQLSSIFSDW HKQISCIQAV
ETVEKFSNRV LLSSLLHFFT QNPLLTIYSD YEEFYDTKSL FVLRVITKAI KLFAENSQSF
DLSFSSIKIH LIEMCKRGFK REQWPNVVYI LKSMKKYIPD QAIGFLHNYS QSFYEIADQI
GGKLQDIYIK TLFFYADYDR SSLLYLTSNN VHFLDNITEI KHPAQIYTIA SLLSKHLQYE
EYKVDKLFKI ILDYFLSGKF LDYKNINKPK NSLLKFSNND HDNFLRQTKN TYNNTHDHNI
ELNFISNKDF NSLHSNSVLS LSTKKLSNHN SFYRNKNGFL SIDNMNESVM LEKKRKSSFR
ILHAHSYDNP KKLILLNPEN YSNDYSCSNN KSNDDYEYQN SLHNNIDRHD STLVHQIQEF
KQKNMKNKKG YCVCDYTKIT QNEIAEYDFI KSIEIFIKLL NYISFSNFDK NQLLSFLLEY
PTNSLCAYIE KNYDVLDLSL IEKSKIFYQK RKCNKYFCRF KLFKTLIKIH SNINFNFEFK
IDVNNFSKED ICKHFIQVMK TKPSLLSKEL KEKIIALKND DNFLKVILCL HKYFPEFDGD
IRELTKNNPV LYLKSLKCTT DPDSRNNILL KFILEESQTK FRLKAIKMLT PTENLANSNF
FYTFLYDHCF KVRKEIFLIL PKFYIINPLF EQPIIRKYII HIISLIRTNN YCDLRIVSKM
AKLADCFGTF CNTLANITPE TNSLSSELIE SLLLILNERY PFERNEDLFF DAASCVSSFG
SCLHSSSLHS SSISPKSNAS FRNQIFLSVD EPLLLKRDKS LLKAISNMGE LCRPYLKSIL
NIFYVIFTTE KHEKFLLSTI KSLNNLCLRI KGGLNFNTEY PEIQKPILHL LKVVKCMNLK
ISLLQLLGSS FDSLNENKGD NTADSTFQNC VVSVIIKTLL SHDFDGHWWK MKVIAVIFEQ
NSERAAGYAI EFIKKIFKFL SVMRNNRPEI LYQCLTIVLL KCPMAIISLM DDLISIIELR
INEISCLKMC VTLIPTLPEE YSIFIQKIYN LVIERMMLYN FHYLKWSIRL LSLAIVHFKM
PIDIYLCKLS RSSLLNEHEV VRSLEYLVQN TDVTNYLAHI YQITRPIKIN TVNLFKSLSE
FQHFEMFDLQ NNFSDKNQKI KFIDLNRNMK SLSHEYSPPE IYFLNMKIFT TIENLNDFVG
YLIVFSFRNS PDVIFRTFSE FVYSAWNLAA HLFPAAFLTI WKICSNEDRA CFSKMLGQRI
EKIKQIKNQE LLNLIEFMDM KGYTFDIDYL KISLSTSSPY YSLLIIQRHF ILNKNLPRSL
TYKIYEISKK LNKKANLQAL FNKFEHCIDP NLTASCHCFL GNWEQALSIY ENENAPLTKK
LLCLFSLRRY DEIVEYYDQF CLLPDDKDKI HSLAVYMWVF AVRRENYKIS EILKKYKFIE
KGNLLYPQIV YYITTKNYNK ANELVDIAFK KLNNYDFEKG DTFSNQKKLC KLQLLSEFNE
IINIYNCEVP TEVCDIWNRR VKDFERVDWM WERLILPRSI LKPINSYHES YIPIISELRK
GGHYEIIHHY FDKTLNLSCK SILYDERLKL EWDEGSNYEA YCLVATTLGF GLVENIYEFI
YLTAYHKIHM PGVLLTSFSQ SPVFGSDLRD YIAYYFETTS FENAMSILME KSPKKQQYFF
THLTTKFPEQ MFNLFSMNVN QHFDFSRVCQ LTGKYSTLFY HEVSFRYYNA ARQMNPCNIS
IMKGWAMVNL SLFIESHSEQ ISNENLAKLD SEELIPIDAD RINESMGSLD LSDESSKQDY
LYDEEEYDQQ NYQENSGDNE NSYGSEKSFN NSNSDEEILI HESLQSLDTS LLRRVSSQAS
FSDPIQNSLL YDQIKPNITI HDENKKDHDN FSFEQDDSID VAQKIINGEA YKVGKTFVAK
NCDRCDEITI SEKDKAVVES RRKILKECTP DMNNHRQFAL NIIDSCLCIV EYDENFYFEF
LVQLFFALFS LKLPDDLPKD LENRILALSP KLILNMLPQI SIHIDCDVAF IEKLFLIACK
EDFQSVYFSL NFHVKNNCQN ASLILERLEN LFSNDKITCL NLSANQINNN KLNYTNISQI
KSQNKFDIHR NSISANHFVP LNNSTNVVKE CRIFDEGLAE LSVNAFEKWK NSIEAASKSF
FNCDNILAVQ YNDFHHPKTE FDHIFIQKFG KKVIECENLF KKHTQDNMIE MWNKLYDLYS
DIDDAWLDLT ELSLSHCSPN LSNYEFHRML IPGSTNTLYI IDEKVKICQT AQRPRCVNFI
VKETGRKCEF LLKSKEDLRN DQRIMQFFNL LNTFFRKSFK RDNLEITRYK IIPLRKDCGL
IRFVKNSESF QQIVEQFRSG NQTTKNRNTY KYQVGSINHE GLIRNQHFNQ QNNEQNVELT
SNQKANKPND HLNNDENKHD VKHSSNQNHV KESNVEYYHE NYCEEQKMNE NNFSDEGNMK
LMSGIIDDIP NKKWKYCIQK APMDIERSLD SEFASETFET MNNLQKYEFF NYVDENTRAI
ELFDAFFHRS RSSFEIVTKM KTFTKSLAVM SMVGYVIGLG DRHPSNILIN VSSGAAIHID
FGDCFESAQK RKKFPEKVPF RLTRMFANAL EGNRSQGYFE QICVKVMKLM RKKKSSLSAQ
LTVFLKESQK EKSSIDKVIR KLSGNELNTE KSAELNNNNA NETVLKQVKV EDQVRKLIEI
AEDPINYCRH FRGWCPFW
//
