ID   A0A1J4KTD7_9EUKA        Unreviewed;      1222 AA.
AC   A0A1J4KTD7;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN   ORFNames=TRFO_17069 {ECO:0000313|EMBL:OHT12918.1};
OS   Tritrichomonas foetus.
OC   Eukaryota; Metamonada; Parabasalia; Tritrichomonadida; Tritrichomonadidae;
OC   Tritrichomonas.
OX   NCBI_TaxID=1144522 {ECO:0000313|EMBL:OHT12918.1, ECO:0000313|Proteomes:UP000179807};
RN   [1] {ECO:0000313|Proteomes:UP000179807}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K {ECO:0000313|Proteomes:UP000179807};
RA   Benchimol M., Almeida L.G., Vasconcelos A.T., Perreira-Neves A., Rosa I.A.,
RA   Tasca T., Bogo M.R., de Souza W.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OHT12918.1}.
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DR   EMBL; MLAK01000552; OHT12918.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J4KTD7; -.
DR   VEuPathDB; TrichDB:TRFO_17069; -.
DR   OrthoDB; 5472060at2759; -.
DR   Proteomes; UP000179807; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   PANTHER; PTHR46093; ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5; 1.
DR   PANTHER; PTHR46093:SF17; MULTIPLE EGF-LIKE-DOMAINS 8; 1.
DR   Pfam; PF13415; Kelch_3; 1.
DR   Pfam; PF13418; Kelch_4; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00612; Kelch; 4.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW   Reference proteome {ECO:0000313|Proteomes:UP000179807};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          199..358
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          889..912
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1124..1222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1124..1150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1151..1167
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1190..1212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1222 AA;  139228 MW;  93950E2325482B3A CRC64;
     MEFIVITHLD SQNICKEIKS DDITISTLKD ELKLVNSLIY IVTPNYQILL RDDQKPNIEY
     PELIQGVALR PHQRPKYYLL IIPELISAAE DQKDVNSTEE ISEDVTVFLH VQSDQKLPFR
     IIPFEFKRNE VNSLNNFFEL CQKKFPLKCD KILFSFSPMT KDLNNSSSLE DLLKYLRYGS
     IVCDITVVEN SDDFLMFKER SDLINSFIID EKDFIHEFTQ LDTFWQPFMT KEQLLEKDDA
     SFVFNSFKST TRAHNFFLQE FKNRAASISM CVGDLFCDLP LFFDSTNDLF SNYQVLDLFF
     KIKCQNTLFL QKIDNATHHV NYHITPFFDL LFLPISRFND FFMFFLKLKK LTPEIHPDFI
     FFQEGELVIN KFLSRMKLWL KKEPTGLLDV VNIQNKLINR MDIMSPRRAL LSSFHGVYSS
     KYTTSGYFYI FNDLILVTKI GRRGEKGKYK MTGVDFRYLT DFRKIIINVT DKKSISFTFE
     SKENFEFALQ QIDDLKNLFY VKLRINDRLV LYNLMDKTSS LNFNIAAASV NMNNSCIYLI
     GGYAWKKFPS NISVLNMKNK TVKTVYNPLV GRKYHAAAEN KGIIYVFGGM NSDSQTLGDF
     ISINTKSGDS MQKITSLHLP TPRFGHSLIS TSNYLIMFGG IDHNKTILSD TSIYTFSNAQ
     WKSLISSEYS PCERAFHSAV VLQNKMIIHG GISSSRVLDD VVMLDLSTMT WITPKLSGDI
     LLPRHSHKVV VYQNWMLVVG GTNESGIVLP PFGIHFDGTT GHVTNFATGG NDRPNLMHFA
     MFVEKNEIFI VGGADKNSDV PSRGIFRIPL PKIVLEKQAI LHTPSTPDED ESLNTNERPK
     SININLNTKT NVNEIINPQK QGRISKFFNK NFKDIFKVNE SYTKNPFLTN SITKNQNESS
     EQSSQPPLIS STEVNSQIKS QNLENDTKSE FNKKSALKLS DNLEQLGSLV SFEDYPKEKI
     YIDDEGDLLP ITALPNIKIT SELPKIPGID QDILPIGSIS SGVHFNESMN DTTKGKNDIR
     VPQTLKSDMG NEIDSNSHQS LLFQNILKNV PEELSSVMGS EQNNKLKNNA CTNDVEIVKP
     MELPAFLTFT NGKADPLPEI NINYEDGHEP IVILPPIYSD STLPPLDLSD SKDKSLNSQD
     SAFISNDNEF ISKDNEGKKK DDPKERSGNF NPFLSMDEDH LFDNADFSLS TPHLGRNPTE
     PEQGTTLNDP PMLNSYLPDG LD
//