ID   A0A1J4L657_9EUKA        Unreviewed;      1299 AA.
AC   A0A1J4L657;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=GAF domain containing protein {ECO:0000313|EMBL:OHT17430.1};
GN   ORFNames=TRFO_12390 {ECO:0000313|EMBL:OHT17430.1};
OS   Tritrichomonas foetus.
OC   Eukaryota; Metamonada; Parabasalia; Tritrichomonadida; Tritrichomonadidae;
OC   Tritrichomonas.
OX   NCBI_TaxID=1144522 {ECO:0000313|EMBL:OHT17430.1, ECO:0000313|Proteomes:UP000179807};
RN   [1] {ECO:0000313|Proteomes:UP000179807}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K {ECO:0000313|Proteomes:UP000179807};
RA   Benchimol M., Almeida L.G., Vasconcelos A.T., Perreira-Neves A., Rosa I.A.,
RA   Tasca T., Bogo M.R., de Souza W.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OHT17430.1}.
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DR   EMBL; MLAK01000003; OHT17430.1; -; Genomic_DNA.
DR   VEuPathDB; TrichDB:TRFO_12390; -.
DR   OrthoDB; 5479253at2759; -.
DR   Proteomes; UP000179807; Unassembled WGS sequence.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.30.450.40; -; 3.
DR   Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002073; PDEase_catalytic_dom.
DR   InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR   PANTHER; PTHR11347; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; 1.
DR   PANTHER; PTHR11347:SF230; HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A; 1.
DR   Pfam; PF01590; GAF; 2.
DR   Pfam; PF00233; PDEase_I; 1.
DR   SMART; SM00065; GAF; 3.
DR   SUPFAM; SSF55781; GAF domain-like; 4.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51845; PDEASE_I_2; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000179807}.
FT   DOMAIN          989..1299
FT                   /note="PDEase"
FT                   /evidence="ECO:0000259|PROSITE:PS51845"
FT   REGION          118..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1299 AA;  145372 MW;  BE3B5A6FD5824EF7 CRC64;
     MATTPNKRRK QRYYDELATK LPAFAANHAT TSLSRRPVTV SIPKRGKIVS VHRKPPDVIK
     QVSTLQFDQD PPPFRPTTPM RRQIHVAPIY PQTAKRNRPK SNLLIDLNIK PVVPDIIRSN
     NTKQQAGTGR STIRSTGRST GRNGEAKESQ IYLSTTRSTS RSLFIPNDSN TNSPITTSIS
     SFSSAENFTG RSDADLDQIK KVELKEIGID DDVNNNDDDD DDDFKMPYIP PLLIEAVTGP
     NLPPSPPPSL SPFTFADEVT QLTDADFDQF LEEDTLFVKS VIVGSRWNTE TIYSFASQLG
     EEQFGIMTDI YFRQAMKIAT IIHLINELLQ LDDISQISQK LEKSLQEIFN VTTCVVWINI
     PSAKTYINYT RLMKYPHGVG IVGNVGADKR EFMTPNPTMC SLYSEEQDLP FCEEAEVINC
     QPIVDPKSNV LYGVILLIDK YHKSGMTYSY WPQSEAFLMN FLTSHLYRVF KKFNSSNAFT
     SNMYKILGKF ISRVHNISRL IPTIKASVTS MIKCENFTIF IKEKDKIITF KYNKSGLQLS
     NISLDKLGIV SRVFKTHEVI NVPTANLDKD FNVSIDNTYK NGVLAVPMIS NGNMIGAFAV
     RGKKHYPCFT TEDINNLTFL TAIATPTIVS SLAMRNRTTE LRKALNAQNK LASLLQTAES
     FARETNLDHL LETIIETSKN LVDADRASLF VVDDSRTQLM TKVADGIKPL LMPINQGIVG
     SVAISGQLIN IPDAYDDPRF NSSVDKQTGY RTRSLVTIPV HDQFGQIIAV MQLMNKKGYK
     PFSDNDVELC KAMCVFAGIA LANSKVIEGA LNSSNRIKAM MKTVKLLNSN DSLSSVLHTI
     MNTLRTLVQA DRSALFTVDK QSSTLSATIN VGEMASIVLT AGKGVVGFIA DTGKSVNIPD
     AYKDERFHSG TDQATGYRTR SILGAPVKDK NGNILAVIEM INKDMATNGG VFTRDDEQLL
     NAFSSFVGFA YSKHKTRDSS QTVAIWLANL FTSESSTAFE PPKTLLLPLD KINTLELPAK
     KINELMKIGF SVFYHSGLCE TFKIQNSKLS RFLLSVFELH KNSRIFTFER AVRSLQFVFY
     IIHNSEIDSF ITPVEKFALL IAALCHNLNY TDEFEGTQMG VALSVLFRNR PPYEIYHCEQ
     TISVLTNVDT NIIETLTLPQ SEIFWHIVFD TVIATDISQH FEIINSTSCL VRPQKLFNKS
     VNLHRLALFK LILKSSDVSD SLRGFEDSKT FSHFSIDLQT TTLFTEIDEA KLNIGFNTIV
     TRPIVSLISD FLPSMSILLD SLNETINGWQ EILNHSLVL
//