ID   A0A1J4MDZ4_9CRYT        Unreviewed;       401 AA.
AC   A0A1J4MDZ4;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Inward rectifier potassium channel C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=cubi_00441 {ECO:0000313|EMBL:OII72446.1};
OS   Cryptosporidium ubiquitum.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX   NCBI_TaxID=857276 {ECO:0000313|EMBL:OII72446.1, ECO:0000313|Proteomes:UP000186176};
RN   [1] {ECO:0000313|EMBL:OII72446.1, ECO:0000313|Proteomes:UP000186176}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=39726 {ECO:0000313|EMBL:OII72446.1};
RA   Liu S., Roellig D.M., Guo Y., Li N., Frace M.A., Tang K., Zhang L.,
RA   Feng Y., Xiao L.;
RT   "Reductive evolution of mitochondrial metabolism and differential evolution
RT   of invasion-related proteins in Cryptosporidium.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC
CC       1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OII72446.1}.
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DR   EMBL; LRBP01000022; OII72446.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J4MDZ4; -.
DR   VEuPathDB; CryptoDB:cubi_00441; -.
DR   OrthoDB; 203792at2759; -.
DR   Proteomes; UP000186176; Unassembled WGS sequence.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.60.40.1400; G protein-activated inward rectifier potassium channel 1; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; INWARD RECTIFIER POTASSIUM CHANNEL; 1.
DR   PANTHER; PTHR11767:SF102; INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU003822};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU003822};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU003822};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW   ECO:0000256|RuleBase:RU003822};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003822};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003822};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW   ECO:0000256|RuleBase:RU003822}.
FT   TRANSMEM        102..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        169..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          67..194
FT                   /note="Potassium channel inwardly rectifying transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   DOMAIN          239..394
FT                   /note="Inward rectifier potassium channel C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17655"
SQ   SEQUENCE   401 AA;  45931 MW;  8291FA22F4A9D3F2 CRC64;
     MMNIELSKPL LKTYTQDQLS CDNGRNQIRS NISSNQSNIS LANSQQNEIR DLISHNSGYT
     QNMLMENGTL NIMHHWDRFS QFFEFCLHDR FHFMLAMSWG NFILFLFLIY ILLAIILALI
     HFIITSGDAA NCIGSDKFGK VEYFFFAVET MFSIGYGSPR SPSCLITNYF TPIMVISGSI
     LNSVTVGIFF TKFSDSTSRK WSICFSKELC GIGFKSTPPE EVLATPTQLN LPPITSYTFT
     KAAETTCEDC PFIISFRLFN ISQEPFFSPD LKVFIIIHTD NGPFITEITS YKLDVPLEFM
     ETPITVSIHS NQPNSPLKNF TINHLRNQGH LIELMVLLRF FDNRTSKNLE VRKTWKLNNI
     FWGYKFSSII KKQVNHDRTM YQVGISDVNN IEPVISGTPF L
//