ID A0A1J4MK14_9CRYT Unreviewed; 1469 AA.
AC A0A1J4MK14;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 22-FEB-2023, entry version 19.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=cubi_03592 {ECO:0000313|EMBL:OII73795.1};
OS Cryptosporidium ubiquitum.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=857276 {ECO:0000313|EMBL:OII73795.1, ECO:0000313|Proteomes:UP000186176};
RN [1] {ECO:0000313|EMBL:OII73795.1, ECO:0000313|Proteomes:UP000186176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=39726 {ECO:0000313|EMBL:OII73795.1};
RA Liu S., Roellig D.M., Guo Y., Li N., Frace M.A., Tang K., Zhang L.,
RA Feng Y., Xiao L.;
RT "Reductive evolution of mitochondrial metabolism and differential evolution
RT of invasion-related proteins in Cryptosporidium.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OII73795.1}.
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DR EMBL; LRBP01000014; OII73795.1; -; Genomic_DNA.
DR VEuPathDB; CryptoDB:cubi_03592; -.
DR OrthoDB; 216133at2759; -.
DR Proteomes; UP000186176; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR PANTHER; PTHR10796:SF92; PATCHED-RELATED, ISOFORM A; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 161..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 763..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 797..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1012..1032
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1284..1306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1313..1333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1339..1365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1386..1404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1410..1443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 767..818
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 1318..1436
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 57..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1469 AA; 167129 MW; 9D94AC8FB647692F CRC64;
MTERTCNLEG NSLSSEDSEA DLEIPLEKVC NDPNPISEQL KRKNNLLIND DLVHSSETDQ
NKGLDGKEGI DGQSGNAESS GLKQKNHSNR IFRRIFECVC RNRSRSNSSN GLNQTSSNNY
RNGGSIFLSI FKGLHGAYLF DKYTKKIGKH ISLVASVYPR SLLIIGNVMG LMFGLVVALG
LMKLYPFHLE VNGSPDLFLP TKSIHNTHKE ELRRLFGPET VTVPILYSNK GPPGSSLLDF
VTLKQIWRNE MSIQAIKVVD KKGKEWGWED ICHRQPTGSV VTGTPCVVLS LFGLFMINES
SGIFSEKDFD EAFTGECCSG VSISKFAAGN LIKQVYFPYQ YKYDEDLPEW PLEIHNTQEM
LSIYRLNTTV PEDVRIAWEN KVTNHIKSVQ RRNQLVSIIN TEERSEISQI NITNKRYEEN
NHTGNFKKLI TVEQPLYNPD SIINSDNTKD VSIYPNNWGI VHYSLEFVSS ETTELANKET
PLLLATFALM IIFMAICISG KFPKRSRVLL SSTVVMITVY ATVGSFATGM IFGVPISPLT
PLFIHMLLGV VVSYMIISVR TYTKTRIYIR VPYHYLPFLN SKYVRISGNE VFLEITQYIY
KPWRGFVFSE AENSHFGNEI MHGNNHSYGS TSVELIYGQN YSSNEISSFN SSNSASDSYS
NQRDQLEQTE KTNIITECTV LGEGNEVPSN KLPSDGNLYH DCKQEESKFT SEIKDDGDEI
HHVINNQIDG SNSDFHIDLE NIDKKMWDND TLLKIRLSVS GSVVFSSITL TCLTSCAALF
LGTVVDFPIV RYYCIHAGFG ILYLFIFHWL IFLPSFVLDE KRIYHRKYDV FPLLKFKLSN
KKSKYLFIRQ EPKFICSDDN QRMIEISPSI NAYTRAASPS NVSLSASNDS RKGTILSIFT
KHVYKVRSEV VKNYQRYKTW WGDKSTNQNK QELVHQRKSN IELNEIDSMV FNEKSSVGVS
NKIDKPFLPP NNRENTAIQN AINEIDMHDI WIGRLMVESS KADVIMRLMC NFTFRLFAFL
FFIVVVILGI VFGKNVNTEF SAVRYLPPNS PLHYFVETLA KSWGSEPRQM YLVFPGSDKV
EWNNKLVREE FINLVDNVLL KDPAVMTPIV SWVHDFEIFH FGTNTPEDPD HIPSFIRECS
PDLDNPRPPP NDAPKEEFYD FLNQWRNRKV LKGDESQEDT ICVVSQLSSK LTASTVSESA
PFIRNIIPEM HDETMLIFKN GNPSEGIQSF RIMTMIKHSP SNSEYNFETV SRLSNLVETV
FEKDFPGTYI YSDWFVEAER DLNILYIVWK LLLYITLGVS IMLCIIQNPL TGIFIGLVVG
GINIAVILIM YITGLIFDIV AFMVLATAVS FSIEYIVHIT HLFLLTKRNS GVERIRDSLL
DMGPNVIYAV ISTFLGVILL AFSTSESFKV FLWITTIVLC VSAISGIMIA PAILSIALDF
GHFIRDYYNR KRQQELDETI LEIKSSNMI
//
