ID A0A1J4N9D8_9ACTN Unreviewed; 402 AA.
AC A0A1J4N9D8;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Nuclease SbcCD subunit D {ECO:0000256|ARBA:ARBA00013365, ECO:0000256|RuleBase:RU363069};
GN Name=sbcD {ECO:0000256|RuleBase:RU363069};
GN ORFNames=UG56_003305 {ECO:0000313|EMBL:OIJ28102.1};
OS Nocardioides luteus.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=1844 {ECO:0000313|EMBL:OIJ28102.1, ECO:0000313|Proteomes:UP000033772};
RN [1] {ECO:0000313|EMBL:OIJ28102.1, ECO:0000313|Proteomes:UP000033772}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BAFB {ECO:0000313|EMBL:OIJ28102.1,
RC ECO:0000313|Proteomes:UP000033772};
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OIJ28102.1, ECO:0000313|Proteomes:UP000033772}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BAFB {ECO:0000313|EMBL:OIJ28102.1,
RC ECO:0000313|Proteomes:UP000033772};
RA Brown L., Ruiz O.N., Gunasekera T.;
RT "Draft Genome Sequence of Nocardioides luteus Strain BAFB, an Alkane-
RT Degrading Bacterium Isolated from JP-7 Polluted Soil.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures can
CC inhibit DNA replication and are intermediates in certain DNA
CC recombination reactions. The complex acts as a 3'->5' double strand
CC exonuclease that can open hairpins. It also has a 5' single-strand
CC endonuclease activity. {ECO:0000256|RuleBase:RU363069}.
CC -!- SUBUNIT: Heterodimer of SbcC and SbcD. {ECO:0000256|ARBA:ARBA00011322,
CC ECO:0000256|RuleBase:RU363069}.
CC -!- SIMILARITY: Belongs to the SbcD family. {ECO:0000256|ARBA:ARBA00010555,
CC ECO:0000256|RuleBase:RU363069}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIJ28102.1}.
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DR EMBL; JZDQ02000004; OIJ28102.1; -; Genomic_DNA.
DR RefSeq; WP_045549780.1; NZ_JZDQ02000004.1.
DR AlphaFoldDB; A0A1J4N9D8; -.
DR STRING; 1844.UG56_003305; -.
DR OrthoDB; 9773856at2; -.
DR Proteomes; UP000033772; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041796; Mre11_N.
DR InterPro; IPR004593; SbcD.
DR InterPro; IPR026843; SbcD_C.
DR NCBIfam; TIGR00619; sbcd; 1.
DR PANTHER; PTHR30337; COMPONENT OF ATP-DEPENDENT DSDNA EXONUCLEASE; 1.
DR PANTHER; PTHR30337:SF0; NUCLEASE SBCCD SUBUNIT D; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF12320; SbcD_C; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW DNA recombination {ECO:0000256|RuleBase:RU363069};
KW DNA replication {ECO:0000256|RuleBase:RU363069};
KW Endonuclease {ECO:0000256|RuleBase:RU363069};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|RuleBase:RU363069};
KW Hydrolase {ECO:0000256|RuleBase:RU363069};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|RuleBase:RU363069};
KW Reference proteome {ECO:0000313|Proteomes:UP000033772}.
FT DOMAIN 1..107
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 268..322
FT /note="Nuclease SbcCD subunit D C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12320"
SQ SEQUENCE 402 AA; 43758 MW; FF91123860AE1248 CRC64;
MRILHTSDWH LGRSFHREGM LGHQAAYVDH LLSVVEQAEV DVVCVSGDVY DRALPQVDAV
RLASEALARL AASRAKVVIT SGNHDSAQRL GFGSELIDAA GIFIRTDLAG VGRPVMLPDE
HGEVAFYGLP YLDPDAARVS WGLESRSHQA ALGEAMRRVR ADVDSRGGRG GRSVVMAHAF
VTGAEPSDSE RDISVGGVSM VPASLFEDIS YAALGHLHGR HTITETVRYS GSPLAYSFSE
ANHLKGSWLI DLDESGFVAS EFVEAPVPRP LARLRGTLEE LLSDPRHEVH EQSWLQITLT
DRIRPAQAME RLRRRFPHTL VLGFESTAPV LGALAQPDPA RPRRDIDLVT EFVAELRGEP
AAKAELALLQ TAVDACCEDP EVDSLDSAAG AADEEEWLEV LF
//
