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Database: UniProt
Entry: A0A1J4NX92_9ACTN
LinkDB: A0A1J4NX92_9ACTN
Original site: A0A1J4NX92_9ACTN 
ID   A0A1J4NX92_9ACTN        Unreviewed;       668 AA.
AC   A0A1J4NX92;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:OIJ65758.1};
GN   ORFNames=WN71_021995 {ECO:0000313|EMBL:OIJ65758.1};
OS   Streptomyces mangrovisoli.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1428628 {ECO:0000313|EMBL:OIJ65758.1, ECO:0000313|Proteomes:UP000034196};
RN   [1] {ECO:0000313|EMBL:OIJ65758.1, ECO:0000313|Proteomes:UP000034196}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MUSC149T {ECO:0000313|Proteomes:UP000034196};
RA   Lee L.-H., Ser H.-L.;
RT   "Genome sequence of Streptomyces mangrovisoli MUSC 149.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004999}.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755}.
CC   -!- SIMILARITY: Belongs to the terpene synthase family.
CC       {ECO:0000256|ARBA:ARBA00006333}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OIJ65758.1}.
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DR   EMBL; LAVA02000051; OIJ65758.1; -; Genomic_DNA.
DR   RefSeq; WP_046588512.1; NZ_LAVA02000051.1.
DR   AlphaFoldDB; A0A1J4NX92; -.
DR   STRING; 1428628.WN71_021995; -.
DR   OrthoDB; 9758578at2; -.
DR   UniPathway; UPA00337; -.
DR   Proteomes; UP000034196; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR006400; Hopene-cyclase.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01507; hopene_cyclase; 1.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000034196};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          40..325
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          336..652
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   668 AA;  73989 MW;  84A0C74602ACD7A8 CRC64;
     MTATTDGSTG ALPPRAASAS ETQLTTPVTA GVQEAAARAV RRATDHLLSR QDAQGWWKGD
     LETNVSMDAE DLLLRQFLGI RDEATTQAAA LFIRGEQRED GTWATFYGGP GELSATIEAY
     VALRLAGDAP DDPHMAKASA WVRERGGIAA ARVFTRIWLA LFGWWKWEDL PELPPELLYF
     PKWFPLNIYN FGCWARQTIV PLTVVSAKRP VRPAPFPLDE LHTDPALPNP PQPLAPATTW
     DGLFQRLDKV VRGYRAVAVR RLRKAALNTA ARWIVERQEN DGCWGGIQPP AVYSVIALYL
     LGYDLEHPVM RAGLESLDRY AIWREDGARM IEACQSPVWD TCLATIALAD AGLPADHPQL
     VKAADWMLGE QVVRPGDWSV RRPGLPPGGW AFEFHNDNYP DIDDTAEVVL ALRRVRHHDP
     ERVEKAIGRG VRWNLGMQSR NGAWGAFDCD NTSRFPNRLP FCDFGEVIDP PSADVTAHVV
     EMLAFEGLSH DPRTRRGIQW LLAEQEPDGS WFGRWGVNYV YGTGSVVPAL TAAGLPVSHP
     AIRRAVTWLE TVQNDDGGWG EDLRSYKHAG EWSGRGASTA SQTAWALMAL LAAGERDSKA
     VERGIEWLAA TQREDGSWDE PYFTGTGFPW DFSINYHLYR QVFPLTALGR YVHQEAAGAA
     PRTEAEGG
//
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