ID A0A1J4NX92_9ACTN Unreviewed; 668 AA.
AC A0A1J4NX92;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:OIJ65758.1};
GN ORFNames=WN71_021995 {ECO:0000313|EMBL:OIJ65758.1};
OS Streptomyces mangrovisoli.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1428628 {ECO:0000313|EMBL:OIJ65758.1, ECO:0000313|Proteomes:UP000034196};
RN [1] {ECO:0000313|EMBL:OIJ65758.1, ECO:0000313|Proteomes:UP000034196}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC149T {ECO:0000313|Proteomes:UP000034196};
RA Lee L.-H., Ser H.-L.;
RT "Genome sequence of Streptomyces mangrovisoli MUSC 149.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755}.
CC -!- SIMILARITY: Belongs to the terpene synthase family.
CC {ECO:0000256|ARBA:ARBA00006333}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIJ65758.1}.
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DR EMBL; LAVA02000051; OIJ65758.1; -; Genomic_DNA.
DR RefSeq; WP_046588512.1; NZ_LAVA02000051.1.
DR AlphaFoldDB; A0A1J4NX92; -.
DR STRING; 1428628.WN71_021995; -.
DR OrthoDB; 9758578at2; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000034196; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000034196};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 40..325
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 336..652
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 73989 MW; 84A0C74602ACD7A8 CRC64;
MTATTDGSTG ALPPRAASAS ETQLTTPVTA GVQEAAARAV RRATDHLLSR QDAQGWWKGD
LETNVSMDAE DLLLRQFLGI RDEATTQAAA LFIRGEQRED GTWATFYGGP GELSATIEAY
VALRLAGDAP DDPHMAKASA WVRERGGIAA ARVFTRIWLA LFGWWKWEDL PELPPELLYF
PKWFPLNIYN FGCWARQTIV PLTVVSAKRP VRPAPFPLDE LHTDPALPNP PQPLAPATTW
DGLFQRLDKV VRGYRAVAVR RLRKAALNTA ARWIVERQEN DGCWGGIQPP AVYSVIALYL
LGYDLEHPVM RAGLESLDRY AIWREDGARM IEACQSPVWD TCLATIALAD AGLPADHPQL
VKAADWMLGE QVVRPGDWSV RRPGLPPGGW AFEFHNDNYP DIDDTAEVVL ALRRVRHHDP
ERVEKAIGRG VRWNLGMQSR NGAWGAFDCD NTSRFPNRLP FCDFGEVIDP PSADVTAHVV
EMLAFEGLSH DPRTRRGIQW LLAEQEPDGS WFGRWGVNYV YGTGSVVPAL TAAGLPVSHP
AIRRAVTWLE TVQNDDGGWG EDLRSYKHAG EWSGRGASTA SQTAWALMAL LAAGERDSKA
VERGIEWLAA TQREDGSWDE PYFTGTGFPW DFSINYHLYR QVFPLTALGR YVHQEAAGAA
PRTEAEGG
//