ID A0A1J4Q028_9ACTN Unreviewed; 2047 AA.
AC A0A1J4Q028;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=VT52_021235 {ECO:0000313|EMBL:OIK25551.1};
OS Streptomyces malaysiense.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1428626 {ECO:0000313|EMBL:OIK25551.1, ECO:0000313|Proteomes:UP000034838};
RN [1] {ECO:0000313|Proteomes:UP000034838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC136T {ECO:0000313|Proteomes:UP000034838};
RA Lee L.H., Chan K.-G.;
RT "Genome sequencing of Streptomyces sp. MUSC136T.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OIK25551.1, ECO:0000313|Proteomes:UP000034838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC136T {ECO:0000313|Proteomes:UP000034838};
RA Lee L.-H., Ser H.-L.;
RT "Genome sequence of Streptomyces malaysiense MUSC 136.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIK25551.1}.
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DR EMBL; LBDA02000051; OIK25551.1; -; Genomic_DNA.
DR RefSeq; WP_071387493.1; NZ_LBDA02000051.1.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000034838; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000034838}.
FT DOMAIN 509..583
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1571..1647
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 590..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1821..1842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1824..1842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2047 AA; 218549 MW; 6E6E1F8B8744E0EA CRC64;
MNAARAHSLG DAFADVVRAR AEHTALVHGD LRLTYRHLAG WAASVADRLC RAGAVGAPVG
IRSPRSAGAV ATVLGAVLAG CAYVPLDPDA PDARLSALVE DFGLRTLCVA PTEADRLRTL
LPGVRILTVD AEMPDPAPLA VAPSAPDTLA YVIATSGTTG RPKGVQVEHR GVLTLARAPE
AGFRPDDVVL QLAPLNVDPS VFEIWGALLN GATLVLPEAA RPGVHDIGRE VRRHRVSVLR
LAAPLFALAM EHITDALRGL RLCVSGGDRA SAKAVRAALR ELPGCRIVNG YGPTETTVYA
CWLVLDAQHP YAEDWPDVPI GRPFADTTVH VVDPDRRPVA LGEEGELCIG GPGVARGYLG
RPDLTADRFV PEPGRPDRTA YLTGDRVRLL PDGNLAFLGR TDDQVKIRGH RVEPVETERA
LLDHPAVRDA AVVAHGTGDR RRLAAFVVLR DVAPEPDLIA HVATLLPSPQ VPATLTALVQ
LPVTPNGKTD RPALAQLAGQ ASDMTGSGLP DTSSERVVAD LWQQALGASV GTDTDFLAAG
GDSLTAMVVL ARLERATGVA LSVGDLFRAA TVRGLAALVD AAALSGTGTP LAVERQPDGT
CTPPAAERQP DTHGRVPLLP GQEGIWFEQQ ARPGKRYVIS RAFLVRGQVD VPRLRRALTR
LGQRQTALRT VVRQHTDGWW QTPDADPGAA VDHHDMTRMP PAEQQHRIRA LIAAGAAAGE
ASPLVRTLVV TLDESTAVVH FDIHHILADD WSLDLFFTEL SALYDDPAAQ LTPLRLTFAD
HVREALDRLP EREHAALEFW RGALKGGAAT ADLVTDHPRP AALSGAGDRV RLRIDAAESA
RYAEAARRHG ISRFMLCLAG VYTVLAAHTE RDSLCLGSLA TGRGRAGTED LVGYFVNLLP
IRVEATADTP VATLFRRIRE ACTAAHAHHH VPFQTVCREL GAAGVSRGSS PFRAVVNHQQ
HPPRPLRLGS APVEPRPPAE DDTAKFELTF TFQESSQGIT LDVEFSTDLY RRDTVERLAG
QLVAVLGRLA DAGPDTALRD IELFEPGERG RLLAAPASER PPAHPDTTLT SLFARTAAAH
PGKTAVVGEE AALTYRELDR LADEMANRLL ARGARPGERV ALCLERTPLL IAAVLGVLKT
GAAYVPLDPA YPAERLRYVL ADARARALVT SKDITDRLFR PGSETDGLPP VLDIDRLVCP
SDEPPPARAG ACATDPAYII YTSGSTGRPR GVVVSHRSVV NTLHAGLARH PFTPDDVWLQ
LTSPGFDVAA YEQFMPLVSG GTLVYCADAA RGDAAALVRA LRDYGVTVMV IVPSLLRALG
RPDLASVRVL IVAGEPADPH DTRHYAQSRV VINGYGPTEA AILATTHEAG PDGDRGRIPI
GRALPGTTAH VIDRHGRLAA TGVPGELWLG GAGLALGYWN NPERTRDLFT TVPVLGDRRL
YRTGDRVRRL PDGNLDYLGR LDGQIKLRGF RIELGEIEAT LTRHQCIGEA VAVLIGQGPD
ADLGVAYVGT ADEQEARAHL VRHLPGHMVP RLVVPVPHIP TSSHGKADRT ALAARLASHA
RDHGPAEEIG RAANPLEQEL LALWREVLGS GPSIGLSDDF FALGGHSLRV IRLLGELERR
YGHRLPVRGF LAEPTVRATA RTLARPDAGT RSATVLAEDV VLDPGITFAG PVTAPRRTDS
VLLTGATGFV GSHVLSELLE RTEGPVLCLV RAATPEAARA RLAQTARRYA LALEAADPRI
VPLPGDLTLP GLGLAGTPGL DAARAAATVL HLGAEVHHLS GYQHLAAANV GGTQELLRIA
AEGRAARFHH VSTLAVLCED TPDGRPRTLS ESTPAEHERH PRGRGYAAAK WAAEQLVRQA
VARGADARTY RLGRAGGSAT TGALSRDDML TRLLVSSAAL GCYPDHPVLA SDALPVDVMA
RALVALALAD APPGTVRHLH HPRRSGLGVF LAGHDRRTGA RTRPVALRTW LARLDDAVAR
GTELPALAYR EHLRELCDAP DRAQPADYRN EATLAALYAH GITPPDWADT VVDRWWQYLA
PTGETSE
//
