ID A0A1J4Q2Q5_9ACTN Unreviewed; 286 AA.
AC A0A1J4Q2Q5;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=3-alpha,7-alpha, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase {ECO:0000313|EMBL:OIK26836.1};
GN ORFNames=VT52_014715 {ECO:0000313|EMBL:OIK26836.1};
OS Streptomyces malaysiense.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1428626 {ECO:0000313|EMBL:OIK26836.1, ECO:0000313|Proteomes:UP000034838};
RN [1] {ECO:0000313|Proteomes:UP000034838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC136T {ECO:0000313|Proteomes:UP000034838};
RA Lee L.H., Chan K.-G.;
RT "Genome sequencing of Streptomyces sp. MUSC136T.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OIK26836.1, ECO:0000313|Proteomes:UP000034838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC136T {ECO:0000313|Proteomes:UP000034838};
RA Lee L.-H., Ser H.-L.;
RT "Genome sequence of Streptomyces malaysiense MUSC 136.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIK26836.1}.
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DR EMBL; LBDA02000033; OIK26836.1; -; Genomic_DNA.
DR RefSeq; WP_046422715.1; NZ_LBDA02000033.1.
DR AlphaFoldDB; A0A1J4Q2Q5; -.
DR OrthoDB; 5522043at2; -.
DR Proteomes; UP000034838; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProtKB-KW.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR CDD; cd03448; HDE_HSD; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR039569; MaoC-like_dehydrat_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR PANTHER; PTHR13078:SF56; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2; 1.
DR PANTHER; PTHR13078; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED; 1.
DR Pfam; PF13452; MaoC_dehydrat_N; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000034838}.
FT DOMAIN 50..133
FT /note="N-terminal of MaoC-like dehydratase"
FT /evidence="ECO:0000259|Pfam:PF13452"
FT DOMAIN 162..264
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
FT REGION 147..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 286 AA; 30343 MW; 3F1EA09874EC5ADB CRC64;
MPIDAARALA AEPRSGGITW TAKDVQLYHL GIGAGRPATD PDELRYTLES RLHVLPSFAT
VAGAGKPGVT GGLSMPGVDV DLASVLHGGQ TLRVHRPIPV EGSATATSRV AAVYDKGNAA
VLVMRTEVGD TEGPLWTNDA QIFVRGEGGW GGDRGPSARL PEPGGEPDRT VECPVRPDQA
LLYRLSGDLN PLHADPEFAK LAGFERPILH GLCTYGMTLK AVADTLLDGD VGRVRSYTTR
FAGVVFPGET LRIRMWREEA GRVRVAVAAA ERDDAPVLAD TVVEHS
//
