ID A0A1J4Q8Y7_9ACTN Unreviewed; 650 AA.
AC A0A1J4Q8Y7;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Serine protease {ECO:0000313|EMBL:OIK29433.1};
GN ORFNames=VT52_001560 {ECO:0000313|EMBL:OIK29433.1};
OS Streptomyces malaysiense.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1428626 {ECO:0000313|EMBL:OIK29433.1, ECO:0000313|Proteomes:UP000034838};
RN [1] {ECO:0000313|Proteomes:UP000034838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC136T {ECO:0000313|Proteomes:UP000034838};
RA Lee L.H., Chan K.-G.;
RT "Genome sequencing of Streptomyces sp. MUSC136T.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OIK29433.1, ECO:0000313|Proteomes:UP000034838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC136T {ECO:0000313|Proteomes:UP000034838};
RA Lee L.-H., Ser H.-L.;
RT "Genome sequence of Streptomyces malaysiense MUSC 136.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIK29433.1}.
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DR EMBL; LBDA02000003; OIK29433.1; -; Genomic_DNA.
DR RefSeq; WP_046421190.1; NZ_LBDA02000003.1.
DR AlphaFoldDB; A0A1J4Q8Y7; -.
DR OrthoDB; 3480681at2; -.
DR Proteomes; UP000034838; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04056; Peptidases_S53; 1.
DR CDD; cd11377; Pro-peptidase_S53; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015366; S53_propep.
DR InterPro; IPR030400; Sedolisin_dom.
DR PANTHER; PTHR14218:SF42; PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14218; PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF09286; Pro-kuma_activ; 1.
DR SMART; SM00944; Pro-kuma_activ; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51695; SEDOLISIN; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000313|EMBL:OIK29433.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000313|EMBL:OIK29433.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000034838};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..650
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018154136"
FT DOMAIN 238..647
FT /note="Peptidase S53"
FT /evidence="ECO:0000259|PROSITE:PS51695"
SQ SEQUENCE 650 AA; 67311 MW; CA4B4BE148A2D682 CRC64;
MRSNSAKTRA VSLAAALPMI AGALALGIPA AHAADSPARN ALKGTKPLWA TAKADKGATN
NGAQVKARVY LAGRDAAGLA AYAKAVSDPS SPHYGKYLSA KKAQARFGAT KAQVAAVKSW
LTSAGLKVTE VTQHYVAVSG DVSSAEKAFG TQLHNYAKGS KTYRAPTQAA SVPAGLKSTV
LTVTGLDSAP HKADHDDALP PPDAVFKNAG PFSSYYGSKT ASTLPDAYGT KLPYAVKGYT
GKQLRSVYGA GKYTGKGVRV AITDAYASPT IAYDAGKYAM RHGDKAWKTS QLHQVLPADY
TKTKECGAAG WYGEETLDVE AVHAVAPDAD VTYVGAASCY DDDLLDSLSK VVDNHLADIV
SNSWGDIEAN QTPDLAAAYD QVFQLGAVQG IGFYFSSGDD GDQVANTGTK QVDTPANSAW
VTAVGGTSLA VGKHNKYMWE TGWGTEKSSL SADGKSWTNF PGAFTSGAGG GTSSTVAEPY
YQKGVVPDSL AKANNASGNR VVPDIAAIAD PNTGFLMGQT QTFPDGSQRY SEYRIGGTSL
AAPTIAAVQA LAEQARGGKA IGFANPSIYA KFGKKGVYHD VTDNPTGHGL GVVRVDYANG
VNASGGLLYS VRSLGKDSSL SATKGYDDVT GVGSPANGYV KSYAKSHKKH
//
