ID A0A1J4T9C2_9BACT Unreviewed; 1207 AA.
AC A0A1J4T9C2;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=AUJ35_03290 {ECO:0000313|EMBL:OIO06815.1};
OS Candidatus Falkowbacteria bacterium CG1_02_41_21.
OC Bacteria; Candidatus Falkowbacteria.
OX NCBI_TaxID=1805147 {ECO:0000313|EMBL:OIO06815.1, ECO:0000313|Proteomes:UP000182860};
RN [1] {ECO:0000313|EMBL:OIO06815.1, ECO:0000313|Proteomes:UP000182860}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CG1_02_41_21 {ECO:0000313|EMBL:OIO06815.1};
RX PubMed=27112493;
RA Probst A.J., Castelle C.J., Singh A., Brown C.T., Anantharaman K.,
RA Sharon I., Hug L.A., Burstein D., Emerson J.B., Thomas B.C., Banfield J.F.;
RT "Genomic resolution of a cold subsurface aquifer community provides
RT metabolic insights for novel microbes adapted to high CO concentrations.";
RL Environ. Microbiol. 0:0-0(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIO06815.1}.
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DR EMBL; MNUV01000060; OIO06815.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J4T9C2; -.
DR Proteomes; UP000182860; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..71
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1207 AA; 136484 MW; E0C7BB1959BB909B CRC64;
MSFVHLHNHS HYSLLDGLTK VEQLVARAKE QGSPAVAITD HGVMYGVIEF YQKCKKAGIK
PIIGVEAYLA PNSRHDKNTR EDARNFHLIL LAKNNVGYKN LIKLTSLAHL EGFYYKPRID
WELLQQYHEG LIACTACLGG EIPRLITGGK LDKARERIMD YQNLFGADSF YLEIQDHPEL
EGQDRVNKQL IAFSKELNVP LVATNDSHYL YKEHEEAQDI LLCLQNKKKL EDTDRMKMLG
YGDYSVRPNA EMIAAFKDTP EAVANTLKIA TMCNVEIELG NIQLPHFEVP EGHDGNSYLR
ELCERGLKKR YGLVLDRVVA EGFASLSSAD VKKIRDRMDY ELEVITKMGW PSYFLIVADF
VNWAKDHKIV VGPGRGSAAG SLVCYLTGIT NLDPLKYDLL FERFLNPERI SMPDIDLDFA
DIRRSEVIKY VKGKYGQDHV SQIITFGTMA ARAAVRDVGR VLNEPYDYCD RLAKMIPMFY
KLDQALNEVA ELKEIYSQEP AAKRILDYAK TLEGVARHSS MHACGVLITK NPLTDYTPIQ
YASSSDKEVV CQYSLHPIED LGLLKVDFLG LKNLTIIESA LRIIKNTRGL EIDIDKIPLD
DLESYRLFQN GETTGIFQFE SSGMKRYLRE LKPNEFEDII AMVALYRPGP MEWIPEYISG
KHQSKKIVYL HPKLEPILEK TYGVAIYQEQ VMQISRELAG FSKGEADTLR KAMGKKIPTL
LAEQKEKFVA GCIQNGVDKE LAEKIFSFIE PFAGYGFNRS HAACYALIGY QTAYLKAHFP
AEFMAALLTS DQNDIDRIAI EIDECRKMGI QIMPPDVNES YATFTVVTSG TTENRAVSTE
EKSNTIRFGL GAVKNVGEHI CEVIIAERKA HGPYSDIFNF LERISDRDLN KKSMESLIKT
GGLDRYGERG ELLANLEMLL NFNKENGKMK DSRQSSLFSD SPHIYVASYP KLIKSPAALE
KDVLRWEKEL LGLYITEHPL NHYLEYLSGF VVPLIELKGR EQEPGVNIAG VISTVKKIIT
RNNQTMLFVK IEDAITNVEL LIFPKLFQET NDMWVVGKIV LGRGRVSDKD QETKVLVNKA
IILDEDNPAK SVDDFKKILL ESRDEARNNY RQGQTYQKPP APVETPVVAG PTAPALKIVF
GRNLDSTELD HLRALFLAYP GDSLVYFKIK NGQQENILKT GFRVAYQPEL IAQIKSDFVG
ALNIVEN
//