ID A0A1J4TSJ9_9BACT Unreviewed; 796 AA.
AC A0A1J4TSJ9;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=AUJ73_03570 {ECO:0000313|EMBL:OIO13613.1};
OS Candidatus Gottesmanbacteria bacterium CG1_02_37_22.
OC Bacteria; Candidatus Gottesmanbacteria.
OX NCBI_TaxID=1805209 {ECO:0000313|EMBL:OIO13613.1, ECO:0000313|Proteomes:UP000183120};
RN [1] {ECO:0000313|EMBL:OIO13613.1, ECO:0000313|Proteomes:UP000183120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CG1_02_37_22 {ECO:0000313|EMBL:OIO13613.1};
RX PubMed=27112493;
RA Probst A.J., Castelle C.J., Singh A., Brown C.T., Anantharaman K.,
RA Sharon I., Hug L.A., Burstein D., Emerson J.B., Thomas B.C., Banfield J.F.;
RT "Genomic resolution of a cold subsurface aquifer community provides
RT metabolic insights for novel microbes adapted to high CO concentrations.";
RL Environ. Microbiol. 0:0-0(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIO13613.1}.
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DR EMBL; MNUY01000054; OIO13613.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J4TSJ9; -.
DR STRING; 1805209.AUJ73_03570; -.
DR Proteomes; UP000183120; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02074; PBP_1a_fam; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 34..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 198..373
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 461..743
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 796 AA; 89588 MW; 92A95513477B9CF6 CRC64;
MEKKNGRNIQ NILSNVMIII LITPIVVLKK IGDLFLFLIN LILLLIRKAY KILIIFILTL
RKNSQNFSKV LSSSSQSFVS LICNRLVNLF SFPKSIFYHK DKKKIKYQVI YQQKKNILRL
DKFFRLPKVS FHLQLDRSIK RKLKILILKI KYFIFGALIT SSIIFVFLLY NLAKSIPNPS
YLSLRDIPST TKIFDRKGKL LYEIYAEENR TPIKLSEIPD VVKNATIAIE DKEFFSHKGF
SLRGIIRALV RNMSSDDLEG GSTITQQLIR SVMLTPEKTL TRKIKELVLS VWTEQLYSKE
QIFEMYFNQV PYGGMTWGIE SAAQTYFGKS VKDLDLAEAA LLVGLPASPS FFSPFGNHPE
LTKQRQRDVL KSMVDAGYIN KEEQDKAQTE ELHLKSPQIP ILAPHFVMYV KETLEKLYGP
KIVEKSGLRV TTSLDYDLQE AAERIVSENI NKLKTFNVGN GALLVTNPNN GEILAMVGSS
DYFNKEKEGN VNVTLSLRPP GSSIKVVNYA LALEKGFTAS SVLNDSPVTY KIDGQNNYTP
VNYDGKFHGR VTLRTALASS YNIPAVKLLS MVGVTDMVEL GRLMGIENWQ DESLFGLSLT
LGGGAVTMLD MARVYGTLAV GGIRHDLTPI IKVTNWQGEI LPIPKSDNNI QALRSEIAYI
ISSILSDNNA RTPAFGPNSA LNIRDKTVAV KTGTSDNKRD NWTIGYTPDY VVAVWVGNND
NTPMHPTLTS GITGAAPIWR EMMDYILKDK ENKPFPLPEN IISVKCNDRL EYYVRGTEPK
GGYPKFLTPT LTPVKE
//
