ID   A0A1J4U735_9BACT        Unreviewed;      1050 AA.
AC   A0A1J4U735;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=AUJ54_05630 {ECO:0000313|EMBL:OIO20338.1};
OS   Ignavibacteria bacterium CG1_02_37_35.
OC   Bacteria; Ignavibacteriota; Ignavibacteria.
OX   NCBI_TaxID=1805220 {ECO:0000313|EMBL:OIO20338.1, ECO:0000313|Proteomes:UP000182308};
RN   [1] {ECO:0000313|EMBL:OIO20338.1, ECO:0000313|Proteomes:UP000182308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CG1_02_37_35 {ECO:0000313|EMBL:OIO20338.1};
RX   PubMed=27112493;
RA   Probst A.J., Castelle C.J., Singh A., Brown C.T., Anantharaman K.,
RA   Sharon I., Hug L.A., Burstein D., Emerson J.B., Thomas B.C., Banfield J.F.;
RT   "Genomic resolution of a cold subsurface aquifer community provides
RT   metabolic insights for novel microbes adapted to high CO concentrations.";
RL   Environ. Microbiol. 0:0-0(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OIO20338.1}.
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DR   EMBL; MNVA01000070; OIO20338.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J4U735; -.
DR   STRING; 1805220.AUJ54_05630; -.
DR   Proteomes; UP000182308; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   PANTHER; PTHR30591; RECBCD ENZYME SUBUNIT RECC; 1.
DR   PANTHER; PTHR30591:SF1; RECBCD ENZYME SUBUNIT RECC; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          280..626
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13361"
FT   DOMAIN          737..1043
FT                   /note="PD-(D/E)XK endonuclease-like"
FT                   /evidence="ECO:0000259|Pfam:PF12705"
SQ   SEQUENCE   1050 AA;  121330 MW;  8C66AA7AC3E623D6 CRC64;
     MILTKKRSFS DALLKVIEDK ILNGKTNEVL HLVPTNRKAR ALKKEIIDKT PARAVSIIPI
     ETIFTLAEKL FSVEVPLSLA SDAASSVLLK KAFQKNQLEY FRSFSKTIPQ GSLDRIKNLF
     SEYKRNGITS EYLLRDLGKT GGTEKQKLSE LAKVYDSYCE LFRQLDLYEI GDVIREVNEF
     SLKDTAERFR ILFPSVKIIY AFGYSEFTNP EISLLKKLSE LPGEDLYIHL DYQRNNRGLF
     SAVEEVKDKF EKEGFYSYPF TRKDNGNKLS GYLSRYLFNE KKIEKKNSYE DAVALIVGKN
     REDEIIQIAK KIKTLLAEKN VPPNAVCVAF HLIQNYSGII RDVFLQYGIP FNLTDRFSLN
     TFNPVISVIN LLEVMATDFY HKAVFRVFSS EYYQPVNAQS SDIYQVASKL RIISGYQTWI
     THINHFIDEE NETEDEILSN KNLLSSVKKE IESLYSLLKK FEEPMTLRQF PERLLALIHE
     LDFPVKVLKL SKEYEEENIK SLTTFIEMFS NLFEQLQLEY EQPESQKFPL KYFLNHLKTA
     VASTRFNIKE RPGYGVLVSN FEEIRGLNFD YVFLGGLCDG DFPTRFSPEI FSYESFSESE
     KKHVTRERFL FYQTLQTCSK RLYLSYPLYE GTKKELSPSS FLVDLKKIFE VDEVLINKNE
     GYIYAFSELI QKAAAQNNME LLLNIKSENE KEILHEKFLI DKTRREHPFE AFAYNGFIDA
     AAEHTAGLLE KYSGSDYSIS QLELYAKCPF QFFLKRILKL TPFEEPSEEL EPMEMGLLLH
     AILEQFMKTV KKENLNLQFE KEKASQLLFA IAKDKIDKLS VHSSLSFWEK EKILGVNGSK
     NDSILSLFLE KELARTDNFE AAFFEVPFGR LRNDDGQKST ILSLNLTSNA KLRGKIDRID
     INFDEKYFKV YDYKLSGKKP NEEDLQLGIS LQIPLYLFAA QQILQNELNE TFLPAAGIIY
     SLKFSREDFG PDEVKTVNRK SYGKAGAETR DKIIQANQDL ISHSLKKIDA LITGISAGVY
     HLSKLEKREE KVCRLCSFKS VCRIQEIEDG
//