ID A0A1J4U9Z1_9BACT Unreviewed; 364 AA.
AC A0A1J4U9Z1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Type III polyketide synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AUJ54_06670 {ECO:0000313|EMBL:OIO19358.1};
OS Ignavibacteria bacterium CG1_02_37_35.
OC Bacteria; Ignavibacteriota; Ignavibacteria.
OX NCBI_TaxID=1805220 {ECO:0000313|EMBL:OIO19358.1, ECO:0000313|Proteomes:UP000182308};
RN [1] {ECO:0000313|EMBL:OIO19358.1, ECO:0000313|Proteomes:UP000182308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CG1_02_37_35 {ECO:0000313|EMBL:OIO19358.1};
RX PubMed=27112493;
RA Probst A.J., Castelle C.J., Singh A., Brown C.T., Anantharaman K.,
RA Sharon I., Hug L.A., Burstein D., Emerson J.B., Thomas B.C., Banfield J.F.;
RT "Genomic resolution of a cold subsurface aquifer community provides
RT metabolic insights for novel microbes adapted to high CO concentrations.";
RL Environ. Microbiol. 0:0-0(2016).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIO19358.1}.
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DR EMBL; MNVA01000086; OIO19358.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J4U9Z1; -.
DR STRING; 1805220.AUJ54_06670; -.
DR Proteomes; UP000182308; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR013601; FAE1_typ3_polyketide_synth.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF08392; FAE1_CUT1_RppA; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
FT DOMAIN 77..224
FT /note="FAE"
FT /evidence="ECO:0000259|Pfam:PF08392"
FT DOMAIN 225..362
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 149
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 364 AA; 40204 MW; 42E55C455C43426C CRC64;
MLINIATANP PYKVSQIKAT EELKKRMAVR PAVARMIDAA SAHSGIDFRY FVVPDGDEES
KEKFYSTNGE YIKPGTQRRM LEYEKWSKEL TKTAVRKLLD ESNVDPSQIN RLITISCTGF
FAPGLDHYLM IEFGIPLSAR RTNVGFMGCA ASLIGFNSVL EAINSSNEKE VNALVVSVEL
CSLHLQTDAT RDNILANMIF ADGSAAALFS NSPRLEEKKR MNLLSADSIM FENTSEFMGW
KIGDFGFEMM LSSELPKIIL EKAIPALQHI LSLYGLSPGQ VHHWVLHPGG RAILDSLQSG
LNLSEDKMEP SRNVLRNYGN MSSASILFVL KELINAGVVN KDEYCCAVAF GPGLTMEVAM
FKGA
//
