ID A0A1J4UTJ3_9ARCH Unreviewed; 316 AA.
AC A0A1J4UTJ3;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=tRNA 2-thiouridine(34) synthase MnmA {ECO:0008006|Google:ProtNLM};
GN ORFNames=AUJ15_00180 {ECO:0000313|EMBL:OIO26939.1};
OS Candidatus Micrarchaeota archaeon CG1_02_55_41.
OC Archaea; Candidatus Micrarchaeota.
OX NCBI_TaxID=1805251 {ECO:0000313|EMBL:OIO26939.1, ECO:0000313|Proteomes:UP000183464};
RN [1] {ECO:0000313|EMBL:OIO26939.1, ECO:0000313|Proteomes:UP000183464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CG1_02_55_41 {ECO:0000313|EMBL:OIO26939.1};
RX PubMed=27112493;
RA Probst A.J., Castelle C.J., Singh A., Brown C.T., Anantharaman K.,
RA Sharon I., Hug L.A., Burstein D., Emerson J.B., Thomas B.C., Banfield J.F.;
RT "Genomic resolution of a cold subsurface aquifer community provides
RT metabolic insights for novel microbes adapted to high CO concentrations.";
RL Environ. Microbiol. 0:0-0(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIO26939.1}.
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DR EMBL; MNVI01000003; OIO26939.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J4UTJ3; -.
DR Proteomes; UP000183464; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd01998; tRNA_Me_trans; 1.
DR Gene3D; 2.30.30.280; Adenine nucleotide alpha hydrolases-like domains; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR046885; MnmA-like_C.
DR InterPro; IPR046884; MnmA-like_central.
DR InterPro; IPR023382; MnmA-like_central_sf.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004506; tRNA-specific_2-thiouridylase.
DR PANTHER; PTHR11933:SF5; MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1; 1.
DR PANTHER; PTHR11933; TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE; 1.
DR Pfam; PF03054; tRNA_Me_trans; 1.
DR Pfam; PF20258; tRNA_Me_trans_C; 1.
DR Pfam; PF20259; tRNA_Me_trans_M; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 183..234
FT /note="tRNA-specific 2-thiouridylase MnmA-like central"
FT /evidence="ECO:0000259|Pfam:PF20259"
FT DOMAIN 244..308
FT /note="tRNA-specific 2-thiouridylase MnmA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20258"
SQ SEQUENCE 316 AA; 35160 MW; A2A58ACC7818AC1A CRC64;
MIGVGLSGGV DSAAATKELL DEGADVLGLF LRLHSDEGKE ARKRSQELGI PFQIVDARAA
FQKSVVQPFI LEYAAGRTPN PCLYCNRNIK FGLLLDAAKK LGCKKLATGH YAKIENARIL
RATDKKKDQS YAFALVKKEA LPFIVLPLGE KNKCEVKRAS NWRGGESQDL CFASSRLNAL
KDLPKKRGRF VFNGETVGEH YGAWFYCVGQ RHGLGRKRLY VKEVDAKENA VVLAERNELY
CESFRVGEKN LHGPLPDEIN LIVRHHQQPV RCRVTGDTVT LLEPLWAPSP GQVAGFYDND
LLVGGAIIKE VQWRVK
//
