ID   A0A1J4Z5K2_9PROT        Unreviewed;       359 AA.
AC   A0A1J4Z5K2;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Arsenical-resistance protein {ECO:0000313|EMBL:OIO78598.1};
GN   ORFNames=AUJ86_04280 {ECO:0000313|EMBL:OIO78598.1};
OS   Hydrogenophilaceae bacterium CG1_02_62_390.
OC   Bacteria; Pseudomonadota; Hydrogenophilia; Hydrogenophilales;
OC   Hydrogenophilaceae.
OX   NCBI_TaxID=1805218 {ECO:0000313|EMBL:OIO78598.1, ECO:0000313|Proteomes:UP000182441};
RN   [1] {ECO:0000313|EMBL:OIO78598.1, ECO:0000313|Proteomes:UP000182441}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CG1_02_62_390 {ECO:0000313|EMBL:OIO78598.1};
RX   PubMed=27112493;
RA   Probst A.J., Castelle C.J., Singh A., Brown C.T., Anantharaman K.,
RA   Sharon I., Hug L.A., Burstein D., Emerson J.B., Thomas B.C., Banfield J.F.;
RT   "Genomic resolution of a cold subsurface aquifer community provides
RT   metabolic insights for novel microbes adapted to high CO concentrations.";
RL   Environ. Microbiol. 0:0-0(2016).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|PIRNR:PIRNR005508}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|PIRNR:PIRNR005508}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59)
CC       family. {ECO:0000256|ARBA:ARBA00010110, ECO:0000256|PIRNR:PIRNR005508}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OIO78598.1}.
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DR   EMBL; MNXE01000031; OIO78598.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J4Z5K2; -.
DR   STRING; 1805218.AUJ86_04280; -.
DR   Proteomes; UP000182441; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015103; F:inorganic anion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR004706; Arsenical-R_Acr3.
DR   InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   NCBIfam; TIGR00832; acr3; 1.
DR   PANTHER; PTHR43057:SF1; ARSENICAL-RESISTANCE PROTEIN 3; 1.
DR   PANTHER; PTHR43057; ARSENITE EFFLUX TRANSPORTER; 1.
DR   Pfam; PF01758; SBF; 1.
DR   PIRSF; PIRSF005508; Acr3; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR005508};
KW   Membrane {ECO:0000256|PIRNR:PIRNR005508, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|PIRNR:PIRNR005508, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|PIRNR:PIRNR005508,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|PIRNR:PIRNR005508}.
FT   TRANSMEM        23..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        95..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        130..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        170..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        195..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        225..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        260..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        295..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        323..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   359 AA;  38790 MW;  32928DCB1F226C78 CRC64;
     MSAQCEVTAK RAAGAPMSLF ERWLSLWVAL CIVAGVVLGQ LFPAPFHALG RMEVAQVNLP
     VGLLIWVMII PMLMKIDFGA LAQVKEHWRG IGVTLLVNWA VKPFSMALLA WLFIRHLFAP
     YLPAEQLDSY VAGLILLAAA PCTAMVFVWS RLTNGDPYFT LSQVALNDTI MIVAFAPIVG
     LLLGLSAITV PWATLFTSVL LYIVIPVLLA QVWRKALLKQ GQVRFDATLA TLGQASILAL
     LATLVLLFAF QGEAILNQPL IIALLAVPIL IQVFFNSALA YWLNRTVGEK HSVACPSALI
     GASNFFELAV AAAISLFGFE SGAALATVVG VLIEVPVMLL VVKIVNRSKG WYEAGITSH
//