ID A0A1J5GAH1_9CYAN Unreviewed; 511 AA.
AC A0A1J5GAH1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=AUK48_14730 {ECO:0000313|EMBL:OIP69292.1};
OS Oscillatoriales cyanobacterium CG2_30_44_21.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales.
OX NCBI_TaxID=1805292 {ECO:0000313|EMBL:OIP69292.1, ECO:0000313|Proteomes:UP000185977};
RN [1] {ECO:0000313|EMBL:OIP69292.1, ECO:0000313|Proteomes:UP000185977}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CG2_30_44_21 {ECO:0000313|EMBL:OIP69292.1};
RX PubMed=27112493;
RA Probst A.J., Castelle C.J., Singh A., Brown C.T., Anantharaman K.,
RA Sharon I., Hug L.A., Burstein D., Emerson J.B., Thomas B.C., Banfield J.F.;
RT "Genomic resolution of a cold subsurface aquifer community provides
RT metabolic insights for novel microbes adapted to high CO concentrations.";
RL Environ. Microbiol. 0:0-0(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIP69292.1}.
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DR EMBL; MNZA01000247; OIP69292.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J5GAH1; -.
DR STRING; 1805292.AUK48_14730; -.
DR Proteomes; UP000185977; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:OIP69292.1};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OIP69292.1}.
FT DOMAIN 6..209
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 264..501
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 511 AA; 55378 MW; 4DC8F2497DB011CD CRC64;
MSGKAYIVGA GIGGIEYLTL RARDVISAAE VIICDDLVDR ALLDLAPIST HRIIAGKRGG
QASVKQTEIN QMLVTHCLEG KQVVRLKSGD PWIFGRSLPE ILALQNANCE WEVIAGISSA
IAAPMLAGIP LTEVDTSSCF AVMTGHDLDR LPWQAIAQIP TLVILMGTNN LAKLIEKLQA
GKSADTLIAI VRWCGRVEQQ VWTGTLADIQ FQLPTGSLSP SVIIIGEVVK FHQTLMQAPN
ALSHQKPSQG KTILVTRANA QASQFTTLLA NQGATVIEMP TLEIKPPTSW ELLDQAIANL
SSYDWLILTS ANAVDSFFKR LREAGKDSRA LHSLQVAVVG QKTAETLANF GIKPDLVPTD
FIADALVDAF MAIPDYNLTH KKMLFPRVES GGREILVEQL QKQGAIVEAI AAYESGCPDR
IDPIALAAIQ KQNIDAIAFT SSKTVKHFCQ LLNQVASEEI WRSWIADVQI ASIGPQTSKT
CHELLGRVDC EALEYTLDGL AEAIVIADHL R
//
