ID A0A1J5HEV7_9CYAN Unreviewed; 740 AA.
AC A0A1J5HEV7;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=AUK48_01420 {ECO:0000313|EMBL:OIP78566.1};
OS Oscillatoriales cyanobacterium CG2_30_44_21.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales.
OX NCBI_TaxID=1805292 {ECO:0000313|EMBL:OIP78566.1, ECO:0000313|Proteomes:UP000185977};
RN [1] {ECO:0000313|EMBL:OIP78566.1, ECO:0000313|Proteomes:UP000185977}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CG2_30_44_21 {ECO:0000313|EMBL:OIP78566.1};
RX PubMed=27112493;
RA Probst A.J., Castelle C.J., Singh A., Brown C.T., Anantharaman K.,
RA Sharon I., Hug L.A., Burstein D., Emerson J.B., Thomas B.C., Banfield J.F.;
RT "Genomic resolution of a cold subsurface aquifer community provides
RT metabolic insights for novel microbes adapted to high CO concentrations.";
RL Environ. Microbiol. 0:0-0(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIP78566.1}.
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DR EMBL; MNZA01000029; OIP78566.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J5HEV7; -.
DR STRING; 1805292.AUK48_01420; -.
DR Proteomes; UP000185977; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.10.1390; ATP-dependent DNA helicase RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029491; Helicase_HTH.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR01389; recQ; 1.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF14493; HTH_40; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:OIP78566.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 26..198
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 225..377
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 535..615
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 740 AA; 84458 MW; 9B2964E0CA0B8CF7 CRC64;
MSDPLTQALK QYFGYDSFRA GQREIIEAFL AGRDTLAIMP TGGGKSICFQ LPALLKKGVT
IVVSPLIALM QDQVTALKEN GIGATFLNST LSGRESNQRS QAILNGATKL IYVAPERLFN
EQFLEFLNIV KNQVGIAGFA IDEAHCVSEW GHDFRPEYRQ LSRIRNSFAD VPMIGLTATA
TERVREDISQ QLALRQPYIH VASFDRTNLY YEVIPKQGGD QSYIHLYQQI KKIQGSGIIY
CLSRKRVNEI AERLRTDGIE AIPYHAGLSA RERDENQTRW IRDDVQVMVA TIAFGMGINK
PDVRFVIHYD LPKNIEGYYQ ESGRAGRDGE DSHCTLFLGY QDLETIKYLI AQKVDPHSNE
PLEAEQRIAH QQLRQVVDYA EGITCRRAIL LRYFGENFHG NCRNCDNCLT PKPMEDWTVE
AQKFLSCVAR TKERFGAGHL IDVLRGSRKE KVLQHHHDQL TTYGIGKDRS LDEWRQLSRS
LVHQGYLTPT TDGYAILKLN DRSWEVMRGQ RQVLLPIERD AEPVVADSRD RGERPIDIEI
LFERLRLLRK NLADEQEVPP YVIFSNATLN QMAEQQPTTR RDFAKLSGVG QKKLEQYADD
FIGIILEHHQ QYPPPEPSEF TDSAKVKTES ITSKPKSSKL ATNQTTLEMY ENGLEIEDIA
RDRGLKPATI WTHLVQLVEA GYAINIDRLV TPERQTVIYE ALEAISGDSL RNLFDHLREA
YTYDEIKIVR AIWQNEKEPL
//
