ID A0A1J5HM36_9BACT Unreviewed; 435 AA.
AC A0A1J5HM36;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=TRAM domain-containing protein {ECO:0000259|PROSITE:PS50926};
GN ORFNames=AUK57_01225 {ECO:0000313|EMBL:OIP86373.1};
OS Candidatus Saccharibacteria bacterium CG2_30_41_52.
OC Bacteria; Candidatus Saccharibacteria.
OX NCBI_TaxID=1805375 {ECO:0000313|EMBL:OIP86373.1, ECO:0000313|Proteomes:UP000183829};
RN [1] {ECO:0000313|EMBL:OIP86373.1, ECO:0000313|Proteomes:UP000183829}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CG2_30_41_52 {ECO:0000313|EMBL:OIP86373.1};
RX PubMed=27112493;
RA Probst A.J., Castelle C.J., Singh A., Brown C.T., Anantharaman K.,
RA Sharon I., Hug L.A., Burstein D., Emerson J.B., Thomas B.C., Banfield J.F.;
RT "Genomic resolution of a cold subsurface aquifer community provides
RT metabolic insights for novel microbes adapted to high CO concentrations.";
RL Environ. Microbiol. 0:0-0(2016).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RNA M5U methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01024}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIP86373.1}.
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DR EMBL; MNZN01000001; OIP86373.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J5HM36; -.
DR STRING; 1805375.AUK57_01225; -.
DR Proteomes; UP000183829; Unassembled WGS sequence.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.40.50.1070; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR030390; MeTrfase_TrmA_AS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002792; TRAM_dom.
DR InterPro; IPR010280; U5_MeTrfase_fam.
DR PANTHER; PTHR11061; RNA M5U METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11061:SF30; TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE; 1.
DR Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR PROSITE; PS50926; TRAM; 1.
DR PROSITE; PS01230; TRMA_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01024};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01024};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01024}.
FT DOMAIN 2..61
FT /note="TRAM"
FT /evidence="ECO:0000259|PROSITE:PS50926"
FT ACT_SITE 392
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10015"
FT ACT_SITE 392
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 274
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 301
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 320
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 365
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
SQ SEQUENCE 435 AA; 49052 MW; 06F987D69CF996CB CRC64;
MKKKILPIVS VKLDKIVGGG QALGTLGGGR KIFVWGGLPG ETVEVQMTKK KSNLAEGIVT
EVITSSANRV SPRDEDSYLS TSPWQIMTFD SEQHYKAALI EEAFELHDIV VPESIEVYSD
NNQYEYRNKI EYSWYWNKES EQLDLSFFRR GTHGKIPVEG TSLAKPAINR AAIAMRDLLR
QKPDLRAFML KTLLVRCDQS DNVAMQLYVK EADFAQFTET EIEKLEVSGF ELIFSNPKSP
ASVITNRLQS WGTTNLTDTI FDIPFTYAVE GFFQINIPVY EQALIDMKQW VIADKPTVDL
YSGVGSIGLT IGGENVTMIE INEHAMIEMK RNIKALDREK AVKAILAPSE TALEYIKGDS
TIIVDPPRAG LHEDVIAKLL ETTPARVIYL SCNPVTQARD VARLAEKYGI RYHRGYNFFP
RTPHIEHLIV LDLKK
//