GenomeNet

Database: UniProt
Entry: A0A1J5TYB3_9GAMM
LinkDB: A0A1J5TYB3_9GAMM
Original site: A0A1J5TYB3_9GAMM 
ID   A0A1J5TYB3_9GAMM        Unreviewed;       407 AA.
AC   A0A1J5TYB3;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   03-JUL-2019, entry version 16.
DE   RecName: Full=Aspartokinase {ECO:0000256|RuleBase:RU003448};
DE            EC=2.7.2.4 {ECO:0000256|RuleBase:RU003448};
GN   ORFNames=BGC33_15290 {ECO:0000313|EMBL:OIR25738.1}, MS2017_1135
GN   {ECO:0000313|EMBL:AYQ56837.1};
OS   Bathymodiolus thermophilus thioautotrophic gill symbiont.
OC   Bacteria; Proteobacteria; Gammaproteobacteria;
OC   sulfur-oxidizing symbionts.
OX   NCBI_TaxID=2360 {ECO:0000313|EMBL:OIR25738.1, ECO:0000313|Proteomes:UP000182798};
RN   [1] {ECO:0000313|Proteomes:UP000182798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BAT/CrabSpa'14 {ECO:0000313|Proteomes:UP000182798};
RA   Ponnudurai R., Kleiner M., Sayavedra L., Thuermer A., Felbeck H.,
RA   Schlueter R., Schweder T., Markert S.;
RT   "Genome Sequence of Bathymodiolus thermophilus sulfur-oxidizing gill
RT   endosymbiont.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:OIR25738.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BAT/CrabSpa'14 {ECO:0000313|EMBL:OIR25738.1};
RX   PubMed=28878861; DOI=10.1186/s40793-017-0266-y;
RA   Ponnudurai R., Sayavedra L., Kleiner M., Heiden S.E., Thurmer A.,
RA   Felbeck H., Schluter R., Sievert S.M., Daniel R., Schweder T.,
RA   Markert S.;
RT   "Genome sequence of the sulfur-oxidizing Bathymodiolus thermophilus
RT   gill endosymbiont.";
RL   Stand. Genomic Sci. 12:50-50(2017).
RN   [3] {ECO:0000313|EMBL:AYQ56837.1, ECO:0000313|Proteomes:UP000278334}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPR9N {ECO:0000313|EMBL:AYQ56837.1,
RC   ECO:0000313|Proteomes:UP000278334};
RA   Won Y.-J.;
RT   "Genome sequence of the bacterial symbiont EPR9N from a vent mussel
RT   Bathymodiolus thermophilus.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-aspartate = 4-phospho-L-aspartate + ADP;
CC         Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC         Evidence={ECO:0000256|RuleBase:RU003448};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC       {ECO:0000256|RuleBase:RU004249}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 1/3.
CC       {ECO:0000256|RuleBase:RU004249}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 1/5.
CC       {ECO:0000256|RuleBase:RU004249}.
CC   -!- SIMILARITY: Belongs to the aspartokinase family.
CC       {ECO:0000256|RuleBase:RU003448}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CP024634; AYQ56837.1; -; Genomic_DNA.
DR   EMBL; MIQH01000001; OIR25738.1; -; Genomic_DNA.
DR   RefSeq; WP_071563172.1; NZ_MIQH01000001.1.
DR   UniPathway; UPA00034; UER00015.
DR   UniPathway; UPA00050; UER00461.
DR   UniPathway; UPA00051; UER00462.
DR   Proteomes; UP000182798; Unassembled WGS sequence.
DR   Proteomes; UP000278334; Chromosome.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04261; AAK_AKii-LysC-BS; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR041740; AKii-LysC-BS.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005260; Asp_kin_monofn.
DR   InterPro; IPR001341; Asp_kinase.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   InterPro; IPR027795; CASTOR_ACT_dom.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF13840; ACT_7; 1.
DR   PIRSF; PIRSF000726; Asp_kin; 2.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00656; asp_kin_monofn; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS51671; ACT; 2.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU004249};
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000726-1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000182798,
KW   ECO:0000313|Proteomes:UP000278334};
KW   Kinase {ECO:0000256|RuleBase:RU003448, ECO:0000313|EMBL:OIR25738.1};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000726-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278334};
KW   Transferase {ECO:0000256|RuleBase:RU003448}.
FT   DOMAIN      265    340       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   DOMAIN      346    407       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND       7     10       ATP. {ECO:0000256|PIRSR:PIRSR000726-1}.
FT   NP_BIND     173    174       ATP. {ECO:0000256|PIRSR:PIRSR000726-1}.
FT   NP_BIND     209    210       ATP. {ECO:0000256|PIRSR:PIRSR000726-1}.
FT   BINDING      47     47       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000726-1}.
FT   BINDING      74     74       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000726-1}.
FT   BINDING     179    179       ATP; via amide nitrogen and carbonyl
FT                                oxygen. {ECO:0000256|PIRSR:PIRSR000726-
FT                                1}.
FT   BINDING     184    184       ATP. {ECO:0000256|PIRSR:PIRSR000726-1}.
SQ   SEQUENCE   407 AA;  43933 MW;  6F266C154D99688D CRC64;
     MALIVQKYGG TSVGSVERIQ AVAEKIKTFV ANGDKLVVSV SAMSGETNRM TELAQQIQDT
     PSLREMDVLL TTGEQVTISL LAMALQQLGC EAISYTGSQV RITTDSAHGK ARIKSIDDHR
     IHASLNAGKI VVVAGFQGVD EQGNITTLGR GGSDTTAVAL AAALKADECQ IYTDVDGVYT
     TDPRIEPNAR KMNTVSYEEM LEMASLGSKV LQIRSVEFAS KYKVPLRVLS SLIDNPIGTL
     ITSEENIMEQ AVISGIAHNK DEAKLSLIGV PDEPGIAYKI LKPISEANIE VDMIVQSVSA
     REGLTNFAFT VHRNDFDRAQ TILQSICNEL EAKAVQSDDK VVKVSLVGIG MRSHAGIAAQ
     MFEVLHQENV NIQMISTSEI KISVVIGEKY LELAVRSLHA AFGLDKE
//
DBGET integrated database retrieval system