ID A0A1J6I4I0_NICAT Unreviewed; 1705 AA.
AC A0A1J6I4I0;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN Name=CHC1_1 {ECO:0000313|EMBL:OIS99417.1};
GN ORFNames=A4A49_24684 {ECO:0000313|EMBL:OIS99417.1};
OS Nicotiana attenuata (Coyote tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=49451 {ECO:0000313|EMBL:OIS99417.1, ECO:0000313|Proteomes:UP000187609};
RN [1] {ECO:0000313|EMBL:OIS99417.1, ECO:0000313|Proteomes:UP000187609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. UT {ECO:0000313|Proteomes:UP000187609};
RC TISSUE=Leaves {ECO:0000313|EMBL:OIS99417.1};
RA Xu S., Brockmoeller T., Gaquerel E., Navarro A., Kuhl H., Gase K., Ling Z.,
RA Zhou W., Kreitzer C., Stanke M., Tang H., Lyons E., Pandey P., Pandey S.P.,
RA Timmermann B., Baldwin I.T.;
RT "The genome of Nicotiana attenuata.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIS99417.1}.
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DR EMBL; MJEQ01037190; OIS99417.1; -; Genomic_DNA.
DR RefSeq; XP_019252135.1; XM_019396590.1.
DR STRING; 49451.A0A1J6I4I0; -.
DR EnsemblPlants; OIS99417; OIS99417; A4A49_24684.
DR GeneID; 109231054; -.
DR Gramene; OIS99417; OIS99417; A4A49_24684.
DR KEGG; nau:109231054; -.
DR OMA; NCDDELI; -.
DR OrthoDB; 5474327at2759; -.
DR Proteomes; UP000187609; Chromosome 8.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF32; CLATHRIN HEAVY CHAIN 1-LIKE; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 2.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 5.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000187609};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 344..367
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
FT COILED 1617..1652
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1705 AA; 193041 MW; E88388C4846EEAF0 CRC64;
MAAANAPITM KEALTLSSIG VNPQFITFTN VTMESDKYIC VRETAPQSSV VIVDMNMPMQ
PLRRPITADS ALMNPNSRIL ALKAQVPGTT QDHLQIFNIE AKQKMKSHQM PEQVVFWKWI
TPKILGIVTQ TSVYHWPIEG DTEPVKMFDR TANLANNQII NYRCDPSEKW LVLIGIAPGS
PERPQLVKGN MQLFSVDQQR SQSLEAHAAS FASFRVPGSD RDSILISFAT RSLNAGQVVS
KLHVIELGAQ PGKPSFTKKQ ADLFFPPDFA DDFPVAMQIS HKYSLIFVIT KLGLLFVYDL
ETATAVYRNR ISPDPIFLTA EASSVGGFYA VNRRGQVLLA TVNETTIIPF ISGQLNNLEL
AVNLAKRGNL PGAENLVVQR FQELFAQTKY KEAAELAAES PQGILRTPDT VAKFQSVPVQ
PGQTPPLLQY FGTLLTKGKL NAFESLELSR LVVNQNKKNL LENWLAEDKL ECSEDLGDLV
KTVDNDLALK IYIKARATPK VVAAFAERRE FDKILIYSKQ VGYTPDYLFL LQTILRSDPQ
GAVNFALMMS QMEGGCPVDY NTITDLFLQR NLIREATAFL LDVLKPNLPE HGFLQTKVLE
INLVTFPNVA DAILANGMFS HYDRSRIAQL CEKAGLYVRA LQHYSELPDI KRVIVNTHAI
EPQALVEFFG TLSREWALEC MKDLLVINIK GNLQIIVQVA KEYCEQLGID ACIKLFEQFK
SYDGLYFFLG SYLSSSEDPD IHFKYIEAAA RTGQIKEVER VTRESNFYDP EKTKNFLMEA
KLPDARPLIN VCDRFGFVPD LTHYLYTNNM LRYIEGYVQK VNPGNAPLVV GQLLDDECPE
DFIKGLILSV RSLLPVEPLV DECEKRNRLR LLTQFLEHLV SEGSQDVHVH NALGKIIIDS
NNNPEHFLTT NPYYDSRVVG KYCEKRDPTL AVVAYRRGNC DDELINVTNK NSLFKLQARY
VVERMDAELW EKVLNPENEF RRQLIDQVVS TALSESKSPE QVSAAVKAFM TADLPHELIE
LLEKIVLQNS AFSGNFNLQN LLILTAIKAD PSRVMDYINR LDNFDGPAVG EVAVEAQLYE
EAFAIFKKFN LNVQAVSVLL DNIRNINRAV EFAFRVEEDA VWSQVAKAQL REGLISDAIE
SFIRADDTTQ FLDVIRAAED ADVYHDLVKY LLMVRQKSKE PKVDSELIYA YAKIDRLSDI
EEFILMPNVA NLPNVGDRLY DEALYEAAKI IFAFISNWAK LASTLVKLNQ FQGAVDAARK
ASSAKTWKEV CFACVDAEEF RLAQICGLNI IVQVDDLEEV SEYYQNRGCF NELISLMESG
LGLERAHMGI FTELGVLYAR YRYEKLMEHI KLFSTRLNIP KLIRACDEQQ HWKELTYLYI
QYDEFDNAAT TVMNHSPDAW DHMQFKDIVV KVANVELYYK AVHFYLQEHP DLINDLLNVL
ALRVDHTRVV DIMRKAGHLR LVKPYMIAVQ SNNVSAVNEA LNEIYVEEED YDRLRESVDL
HDNFDQIGLA QKIEKHELLE MRRVAAYIYK RAGRWKQSIA LSKKDNLYKD AMETASQSGD
RELAEELLVY FIEQGKKECF ASCLFVCYDL IRPDVALELA WMNNMIDFAF PYLLQFIREY
TGKVDELIKD KIEAQNEAKA KENEEKDVMK QQNMYAQLLP LALPAPPGMG GAGMGGGFAP
PPPPPMGGMG MPPMPPFGMP PMGPY
//
