ID A0A1J6I4K7_NICAT Unreviewed; 1308 AA.
AC A0A1J6I4K7;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Pleiotropic drug resistance protein 1 {ECO:0000313|EMBL:OIS99441.1};
GN Name=PDR1_7 {ECO:0000313|EMBL:OIS99441.1};
GN ORFNames=A4A49_62654 {ECO:0000313|EMBL:OIS99441.1};
OS Nicotiana attenuata (Coyote tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=49451 {ECO:0000313|EMBL:OIS99441.1, ECO:0000313|Proteomes:UP000187609};
RN [1] {ECO:0000313|EMBL:OIS99441.1, ECO:0000313|Proteomes:UP000187609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. UT {ECO:0000313|Proteomes:UP000187609};
RC TISSUE=Leaves {ECO:0000313|EMBL:OIS99441.1};
RA Xu S., Brockmoeller T., Gaquerel E., Navarro A., Kuhl H., Gase K., Ling Z.,
RA Zhou W., Kreitzer C., Stanke M., Tang H., Lyons E., Pandey P., Pandey S.P.,
RA Timmermann B., Baldwin I.T.;
RT "The genome of Nicotiana attenuata.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000256|ARBA:ARBA00006012}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIS99441.1}.
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DR EMBL; MJEQ01037190; OIS99441.1; -; Genomic_DNA.
DR EnsemblPlants; OIS99441; OIS99441; A4A49_62654.
DR Gramene; OIS99441; OIS99441; A4A49_62654.
DR OMA; TIAQPMM; -.
DR Proteomes; UP000187609; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR PANTHER; PTHR48040:SF37; PLEIOTROPIC DRUG RESISTANCE PROTEIN 1; 1.
DR PANTHER; PTHR48040; PLEIOTROPIC DRUG RESISTANCE PROTEIN 1-LIKE ISOFORM X1; 1.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000187609};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 408..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1057..1075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1143..1163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1170..1194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1200..1220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1232..1251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1277..1300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..312
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 711..963
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1308 AA; 147833 MW; 875ABAC48102731C CRC64;
MPSIEVRYEN LTIEADAYVG SRALPTFINF ITNFFETMLN SVHILPSKKR QITILKDVSG
MIKPCRLTLL LGPPSSGKTT FLLALAGKLD PTLRVNGKVT YNGHELHEFV PQRTAVYISQ
HDLHIGEMTV RETLEFSARC QGVGSRYQML AELSRREKEA NIKPDPDLDI YMKAAATEGQ
EANVYTDYVL KILGLDVCAD TMVGDEMLRG ISGGQKKRVT TGEMLVGPAK ALFMDEISTG
LDSSTTFSIV NSLRQSVQLM KGTTVISLLQ PAPETYNLFD DIILLSDGYI VYQGPRESVL
DFFDSMGFKC PERKGVADFL QEVTSKKDQQ QYWAKKDEPY RFITSKEFAE AYQSFHVGKK
LSDELATPYD KSKSHPAALS TQKYGIGTKQ LLKVCAEREF LLMKRNSFVY IFKLFQLVVM
ALITMTVFFR TKMPRDDMDD GGIYAGALFF VVVQIMFNGM AEINLTILKL PVYFKQRDLL
FFPSWAYALP TWILKIPITI VEVAIWTFLT YYVMGFDPNV SRLFKQFFLL VLVHQMASAL
YRFIGAAGRT MGVASTFGAF ALILQFALSG FILSRDDVKK WWIWAYWISP LMYSMNSILV
NEFDGKNWKH IAPNGNESLG AAVVRARGFF PDAYWYWIGI GALIGFIMIL NIFYSLGLAY
LKPFGKPQAM ISEDDENADN VRLISPEGGD SVSDGQNKKR GMVLPFEPHS ITFDDVVYSV
DMPQEMKGQG STEDRLVLLK GVSGSFRPGV LTALMGVSGA GKTTLMDVLA GRKTGGYIDG
SIKISGYPKK QETFARVSGY CEQNDIHSPY VTVYESLVYS AWLRLPQDVD ENKRKMFVEE
VMELVELTPL RSALVGLPGV NGLSTEQRKR LTIAVELVAN PSIIFMDEPT SGLDARAAAI
VMRAVRNTVD TGRTVVCTIH QPSIDIFEAF DELFLMKRGG QEIYVGPLGR HSCHLIKYFE
SMPGVSKIKE AYNPATWMLE VTASSQEMTL GVDFADLYKK SDLYKRNKAL IAELSTPRPG
TKDLHFDTQF SQPFWTQCMA CLWKQYWSYW RNPSYTAVRF IFTLFIALVF GTMFWDLGTK
VSRSQDLFNA MGSMYAACLF LGVQNSSSVQ PVVAVERTVF YRERAAGMYS AIPYAIGQVI
VELPYVFVQA AFYGIIVYAM IGFEWTAAKF FWYFFFMYFT LLYFTFYGMM TVAITPNQNV
ASIVAAFFYA VWNLFSGFIV PRPRIPIWWR WYYWACPVAW TLYGLVASQF ADLQNDLGNN
ENVKQFLSRY FGFEHDFLGV VAVVIVALPV MFAVIFALAI KALNFQRR
//
