ID   A0A1J6J1E7_NICAT        Unreviewed;       538 AA.
AC   A0A1J6J1E7;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Adenineguanine permease azg2 {ECO:0000313|EMBL:OIT04803.1};
GN   Name=AZG2 {ECO:0000313|EMBL:OIT04803.1};
GN   ORFNames=A4A49_06338 {ECO:0000313|EMBL:OIT04803.1};
OS   Nicotiana attenuata (Coyote tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=49451 {ECO:0000313|EMBL:OIT04803.1, ECO:0000313|Proteomes:UP000187609};
RN   [1] {ECO:0000313|EMBL:OIT04803.1, ECO:0000313|Proteomes:UP000187609}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. UT {ECO:0000313|Proteomes:UP000187609};
RC   TISSUE=Leaves {ECO:0000313|EMBL:OIT04803.1};
RA   Xu S., Brockmoeller T., Gaquerel E., Navarro A., Kuhl H., Gase K., Ling Z.,
RA   Zhou W., Kreitzer C., Stanke M., Tang H., Lyons E., Pandey P., Pandey S.P.,
RA   Timmermann B., Baldwin I.T.;
RT   "The genome of Nicotiana attenuata.";
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OIT04803.1}.
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DR   EMBL; MJEQ01037185; OIT04803.1; -; Genomic_DNA.
DR   RefSeq; XP_019243566.1; XM_019388021.1.
DR   AlphaFoldDB; A0A1J6J1E7; -.
DR   STRING; 49451.A0A1J6J1E7; -.
DR   EnsemblPlants; OIT04803; OIT04803; A4A49_06338.
DR   GeneID; 109223637; -.
DR   Gramene; OIT04803; OIT04803; A4A49_06338.
DR   KEGG; nau:109223637; -.
DR   OMA; RKGSYFF; -.
DR   OrthoDB; 35157at2759; -.
DR   Proteomes; UP000187609; Chromosome 3.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR   InterPro; IPR045018; Azg-like.
DR   InterPro; IPR006043; NCS2.
DR   PANTHER; PTHR43337:SF13; ADENINE_GUANINE PERMEASE AZG2; 1.
DR   PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187609};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        113..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        197..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        254..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        414..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        489..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   538 AA;  57923 MW;  E3F8ACB52FDAA8CD CRC64;
     MGRELCSTGS FRKSLTKMEM KINEAISKSR IGKYFKLEAR KSSFTKEFRA GTATFLTMAY
     IITVNASVLS DSGGTCSVSD CTFPANQTRA NPDCMLKPNE GYEKCISKMR SDLIVATALA
     SMIGSFAMGL LANLPLGLAP GMGPNAYLAY NLVGFHGSGK MSYQTVMAIF LVEGCAFLAI
     AVFGLRGRIA RFIPQPVRLA CAAGIGLFIA FVGLQAHQGV GLVGPDPSTL LTLTACSSTN
     PVTGECTGGK MQSPTFWLSS VGFIIMCYGL MKEIKGSMIY GILFVTLISW IRNTAVTIFP
     NTSSGNSSYE YFKKVVDFHK IESTAGAINF SHFNNGEVWV ALLTLLYIDV LATTGTLYTM
     AEIGGFVNEE GEFEGEYIAY MVDAGSTIVA STLGVSPIAT FVESSAGIKE GGRTGLTAII
     VGFYFLLSLF FTPLIASVPP WAIGPSLVMV GVLMMKVVKD IDWNNIKHAV PAFVTMVLMP
     LTYSISNGII GGIGVYIALS LYDSMVCWVK WLMRMRKMVV KEQNQVSAAT ADQNIEIV
//