ID A0A1J6J7C5_NICAT Unreviewed; 353 AA.
AC A0A1J6J7C5;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Two pore potassium channel a {ECO:0000313|EMBL:OIT05743.1};
GN Name=TPKA {ECO:0000313|EMBL:OIT05743.1};
GN ORFNames=A4A49_02286 {ECO:0000313|EMBL:OIT05743.1};
OS Nicotiana attenuata (Coyote tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=49451 {ECO:0000313|EMBL:OIT05743.1, ECO:0000313|Proteomes:UP000187609};
RN [1] {ECO:0000313|EMBL:OIT05743.1, ECO:0000313|Proteomes:UP000187609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. UT {ECO:0000313|Proteomes:UP000187609};
RC TISSUE=Leaves {ECO:0000313|EMBL:OIT05743.1};
RA Xu S., Brockmoeller T., Gaquerel E., Navarro A., Kuhl H., Gase K., Ling Z.,
RA Zhou W., Kreitzer C., Stanke M., Tang H., Lyons E., Pandey P., Pandey S.P.,
RA Timmermann B., Baldwin I.T.;
RT "The genome of Nicotiana attenuata.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.7) family. {ECO:0000256|ARBA:ARBA00010159}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIT05743.1}.
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DR EMBL; MJEQ01037184; OIT05743.1; -; Genomic_DNA.
DR RefSeq; XP_019223802.1; XM_019368257.1.
DR RefSeq; XP_019223807.1; XM_019368262.1.
DR AlphaFoldDB; A0A1J6J7C5; -.
DR EnsemblPlants; OIT05743; OIT05743; A4A49_02286.
DR GeneID; 109205547; -.
DR Gramene; OIT05743; OIT05743; A4A49_02286.
DR KEGG; nau:109205547; -.
DR OMA; MDGDHRV; -.
DR OrthoDB; 38977at2759; -.
DR Proteomes; UP000187609; Chromosome 2.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProt.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF271; POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000313|EMBL:OIT05743.1};
KW Ion transport {ECO:0000313|EMBL:OIT05743.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000187609};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 69..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..151
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 194..267
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
SQ SEQUENCE 353 AA; 39828 MW; C72B08B917943DC0 CRC64;
MDKGDVEQPL LRSHVNSSIR FSDINSFKRR RTQSSSSTGN ISHIPQTNNE ELFHSSESIA
TERFRLRSVL LFLAVYIGVG AICFFIIRDQ IEGKKTNGIL DAIYLCIVTM TTVGYGDLVP
KSILAKLLAC IFVFTGMALV GFVLSKAADS FLERQQILFL KAIKMRKNYS SSNEVLKEVE
TNIEKYKFLS ALALLVMFTI LGTIFLNQVE DLSLFDAFYC VCATITTLGY GDKSFSTKWG
RLFASFWILL STICLGQLFY SLAELYTEQR RKSMTRWVLT RELTNSDLQA ADLDHDSEVS
AAEFIVYKLK ELGKITEEDV CVVMESFKML DVDHSGTLTE KDIALLHSSR SKS
//
