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Database: UniProt
Entry: A0A1J6XAI4_9MICO
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ID   A0A1J6XAI4_9MICO        Unreviewed;       396 AA.
AC   A0A1J6XAI4;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   11-DEC-2019, entry version 18.
DE   RecName: Full=Xylose isomerase {ECO:0000256|HAMAP-Rule:MF_00455, ECO:0000256|RuleBase:RU000609};
DE            EC=5.3.1.5 {ECO:0000256|HAMAP-Rule:MF_00455, ECO:0000256|RuleBase:RU000609};
GN   Name=xylA {ECO:0000256|HAMAP-Rule:MF_00455};
GN   ORFNames=BFN01_10190 {ECO:0000313|EMBL:OIU87229.1};
OS   Microbacterium sp. AR7-10.
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae; Microbacterium.
OX   NCBI_TaxID=1891970 {ECO:0000313|EMBL:OIU87229.1, ECO:0000313|Proteomes:UP000183831};
RN   [1] {ECO:0000313|EMBL:OIU87229.1, ECO:0000313|Proteomes:UP000183831}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR7-10 {ECO:0000313|EMBL:OIU87229.1,
RC   ECO:0000313|Proteomes:UP000183831};
RA   Pei D., Jiang J., Chen H., Li K., Yu W., Ma Y., Xu J.;
RT   "The draft genome of Microbacterium sp. AR7-10 isolated from the wild
RT   caught mosquito Anopheles.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-xylose = D-xylulose; Xref=Rhea:RHEA:22816,
CC         ChEBI:CHEBI:17140, ChEBI:CHEBI:53455; EC=5.3.1.5;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00455,
CC         ECO:0000256|RuleBase:RU000609};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00455};
CC       Note=Binds 2 magnesium ions per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00455};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00455,
CC       ECO:0000256|RuleBase:RU000610}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00455,
CC       ECO:0000256|RuleBase:RU000610}.
CC   -!- SIMILARITY: Belongs to the xylose isomerase family. {ECO:0000256|HAMAP-
CC       Rule:MF_00455, ECO:0000256|RuleBase:RU000609,
CC       ECO:0000256|SAAS:SAAS00580662}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_00455}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OIU87229.1}.
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DR   EMBL; MJIR01000062; OIU87229.1; -; Genomic_DNA.
DR   RefSeq; WP_071643594.1; NZ_MJIR01000062.1.
DR   Proteomes; UP000183831; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009045; F:xylose isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00455; Xylose_isom_A; 1.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   InterPro; IPR013453; XylA_actinobac.
DR   InterPro; IPR001998; Xylose_isomerase.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PRINTS; PR00688; XYLOSISMRASE.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR02631; xylA_Arthro; 1.
DR   PROSITE; PS51415; XYLOSE_ISOMERASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|HAMAP-Rule:MF_00455,
KW   ECO:0000256|RuleBase:RU000609, ECO:0000256|SAAS:SAAS00472203};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00455};
KW   Isomerase {ECO:0000256|HAMAP-Rule:MF_00455, ECO:0000256|RuleBase:RU000609,
KW   ECO:0000256|SAAS:SAAS00108565, ECO:0000313|EMBL:OIU87229.1};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00455};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00455,
KW   ECO:0000256|RuleBase:RU000609, ECO:0000256|SAAS:SAAS00472349};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183831};
KW   Xylose metabolism {ECO:0000256|HAMAP-Rule:MF_00455,
KW   ECO:0000256|RuleBase:RU000609}.
FT   DOMAIN          42..265
FT                   /note="AP_endonuc_2"
FT                   /evidence="ECO:0000259|Pfam:PF01261"
FT   ACT_SITE        54
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   ACT_SITE        57
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   METAL           181
FT                   /note="Magnesium 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   METAL           217
FT                   /note="Magnesium 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   METAL           217
FT                   /note="Magnesium 2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   METAL           220
FT                   /note="Magnesium 2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   METAL           245
FT                   /note="Magnesium 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
FT   METAL           293
FT                   /note="Magnesium 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00455"
SQ   SEQUENCE   396 AA;  43304 MW;  267F3AE392850C62 CRC64;
     MSLTPTKADR FSFGLWTIGY NGTDPFGGPT RPALDVVHAV EKLDELGAYG LTFHDDDLFA
     FGSTDAERQK QIDRLKGALD ATGLIVPMVT TNLFSAPVFK DGGFTSNDRQ VRRFALRKVL
     RNIDLAAELG ASTFVMWGGR EGAEYDSAKD IQAALERYRE AVNLLGDYVT DKGYDIRFAI
     EPKPNEPRGD ILLPTLGHAI AFIDSLERPE LVGLNPEVGH EQMAGLNFTA GIAQALYHGK
     LFHIDLNGQR GIKYDQDLVF GHGDLNNAFS LVDLLEHGGP NGGAAYDGPR HFDYKPSRTE
     DETGVWDSAA ANMRMYLLLK ERAAAFRADP EVQEALAAAK VAELAQPTLG EGESYDDLLA
     DRSAFEDFDS AAYLGGHGFG FVRLQQLATE HLMGAR
//
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