ID A0A1J7BC17_9ACTN Unreviewed; 665 AA.
AC A0A1J7BC17;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=BIV57_17245 {ECO:0000313|EMBL:OIV36239.1};
OS Mangrovactinospora gilvigrisea.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Mangrovactinospora.
OX NCBI_TaxID=1428644 {ECO:0000313|EMBL:OIV36239.1, ECO:0000313|Proteomes:UP000243342};
RN [1] {ECO:0000313|EMBL:OIV36239.1, ECO:0000313|Proteomes:UP000243342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC 26 {ECO:0000313|EMBL:OIV36239.1,
RC ECO:0000313|Proteomes:UP000243342};
RA Lee L.-H., Ser H.-L.;
RT "Genome sequence of Streptomyces gilvigriseus MUSC 26.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIV36239.1}.
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DR EMBL; MLCF01000105; OIV36239.1; -; Genomic_DNA.
DR RefSeq; WP_071657787.1; NZ_MLCF01000105.1.
DR AlphaFoldDB; A0A1J7BC17; -.
DR STRING; 1428644.BIV57_17245; -.
DR OrthoDB; 9762169at2; -.
DR Proteomes; UP000243342; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd06577; PASTA_pknB; 4.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.30.10.20; -; 4.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR NCBIfam; NF033483; PknB_PASTA_kin; 1.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF32; SERINE_THREONINE-PROTEIN KINASE PKAB; 1.
DR Pfam; PF03793; PASTA; 4.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00740; PASTA; 4.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51178; PASTA; 4.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000243342}.
FT DOMAIN 18..282
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 400..466
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 467..534
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 535..600
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 601..664
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT REGION 284..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 68972 MW; 2EE89BE5E3EF265C CRC64;
MDTTLRDPLV GQLLDHRYRV ESRLAVGGMA TVYKALDTRL DRVMALKVMH PALAADGEFV
ARFIREAKAV ARLSHANVVA VYDQGRDGDH VFLAMEFIDG CTLRDIIGTR GALTPRVALD
ILEPVVAALG AAHRAGLVHR DVKPENVLIA ADGRVKVADF GLVRAVTGGT NHTTAGTVLG
TVAYLAPEQI EYGTADQRTD VFACGLLLYE LLTGVRAQEG ATPSQAMYKR VNEPVPVPSL
RLPGLAPELD ALIGRTTALA PDARPADAIA LLALVQATRR ALTEAQLDRE PPAAPVPVRE
GAAGEEGPQP IPGTTDPTTQ LAAGLPPVNP TRVQALPSDI IMPVPVQWHD DNTAVHPVGT
PPPGEPPRHR GWRPPHPKRA AAILVAVLVL GGGLTWYTVA GRYTAAPAVL GLTRSEAAAK
LDKAGLHPAF VQRFSESVQP GRVVSTDPGA GGNVQRGGTV DVVLSKGPER FAVPDVKGAG
LAQATQALKA RHLIVGRVER AFSSSVPAGQ VLSSNPAAGS SLAAGTAVDL AVSKGSPVQV
PDVTGEDLSS AEQDLTDAGF KPVVSPTQVN SPDVAAGQVA KQSPSDVAPQ GSKVTLYVSA
GAKQVTVPDV TGMKVDEAKK VLKKAGFKAS TGFHLFGGNT VKSTSPAAGQ QAPEGSTVNL
DTGGL
//
