ID A0A1J7C627_9GAMM Unreviewed; 323 AA.
AC A0A1J7C627;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 13-SEP-2023, entry version 20.
DE RecName: Full=PTS system mannose-specific EIIAB component {ECO:0000256|ARBA:ARBA00021685};
DE EC=2.7.1.191 {ECO:0000256|ARBA:ARBA00011929};
DE AltName: Full=EIIAB-Man {ECO:0000256|ARBA:ARBA00032197};
DE AltName: Full=EIII-Man {ECO:0000256|ARBA:ARBA00030229};
GN ORFNames=BK025_11860 {ECO:0000313|EMBL:OIV46398.1};
OS Sodalis sp. TME1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Bruguierivoracaceae; Sodalis.
OX NCBI_TaxID=1912097 {ECO:0000313|EMBL:OIV46398.1, ECO:0000313|Proteomes:UP000181913};
RN [1] {ECO:0000313|EMBL:OIV46398.1, ECO:0000313|Proteomes:UP000181913}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TME1 {ECO:0000313|EMBL:OIV46398.1,
RC ECO:0000313|Proteomes:UP000181913};
RA Rosas-Perez T., Vera-Ponce De Leon A., Rosenblueth M., Ramirez-Puebla S.T.,
RA Rincon-Rosales R., Martinez-Romero J., Dunn M.F., Martinez-Romero E.;
RT "The Symbiome of Llaveia Cochineals (Hemiptera: Coccoidea: Monophlebidae)
RT Includes a Gammaproteobacterial Co-symbiont Sodalis TME1 and the Known
RT Candidatus Walczuchella monophlebidarum.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC system (sugar PTS), a major carbohydrate active transport system,
CC catalyzes the phosphorylation of incoming sugar substrates
CC concomitantly with their translocation across the cell membrane. The
CC enzyme II ManXYZ PTS system is involved in mannose transport.
CC {ECO:0000256|ARBA:ARBA00023757}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-
CC mannose 6-phosphate(in) + L-histidyl-[protein]; Xref=Rhea:RHEA:49232,
CC Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:9746, ChEBI:CHEBI:4208,
CC ChEBI:CHEBI:29979, ChEBI:CHEBI:58735, ChEBI:CHEBI:64837;
CC EC=2.7.1.191; Evidence={ECO:0000256|ARBA:ARBA00000514};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIV46398.1}.
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DR EMBL; MNBX01000364; OIV46398.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J7C627; -.
DR Proteomes; UP000181913; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00006; PTS_IIA_man; 1.
DR CDD; cd00001; PTS_IIB_man; 1.
DR Gene3D; 3.40.50.510; Phosphotransferase system, mannose-type IIA component; 1.
DR Gene3D; 3.40.35.10; Phosphotransferase system, sorbose subfamily IIB component; 1.
DR InterPro; IPR013789; PTS_EIIA_man.
DR InterPro; IPR004701; PTS_EIIA_man-typ.
DR InterPro; IPR036662; PTS_EIIA_man-typ_sf.
DR InterPro; IPR033887; PTS_IIA_man.
DR InterPro; IPR004720; PTS_IIB_sorbose-sp.
DR InterPro; IPR036667; PTS_IIB_sorbose-sp_sf.
DR InterPro; IPR018455; PTS_IIB_sorbose-sp_subgr.
DR NCBIfam; TIGR00824; EIIA-man; 1.
DR NCBIfam; TIGR00854; pts-sorbose; 1.
DR PANTHER; PTHR33799:SF1; PHOSPHOTRANSFERASE ENZYME IIA COMPONENT YADI-RELATED; 1.
DR PANTHER; PTHR33799; PTS PERMEASE-RELATED-RELATED; 1.
DR Pfam; PF03610; EIIA-man; 1.
DR Pfam; PF03830; PTSIIB_sorb; 1.
DR SUPFAM; SSF52728; PTS IIb component; 1.
DR SUPFAM; SSF53062; PTS system fructose IIA component-like; 1.
DR PROSITE; PS51096; PTS_EIIA_TYPE_4; 1.
DR PROSITE; PS51101; PTS_EIIB_TYPE_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Reference proteome {ECO:0000313|Proteomes:UP000181913};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..126
FT /note="PTS EIIA type-4"
FT /evidence="ECO:0000259|PROSITE:PS51096"
FT DOMAIN 160..323
FT /note="PTS EIIB type-4"
FT /evidence="ECO:0000259|PROSITE:PS51101"
SQ SEQUENCE 323 AA; 34531 MW; 2D83AF843369D95E CRC64;
MSIAIVIGTH GSAAEQLLKT AEMILGAQDN VAWIDFVPGE NAETLIEKYT ARLADLDTTA
GVLFLVDTWG GSPFNAASRI VIDKENYEVV TGVNIPMLAE TFMARDDNPT FQELVGIAVE
TGRIGVKALK APEEKQAAPA AAPAPAPVAK AAPVVAGQGG HMSIGLARID DRLIHGQVAT
RWTKETNVKR IIVVSDEVAA DTVRKTLLTQ VAPPGVTAHV VDVAKAIRVY DNPKYANDRV
MLLFTNPTDV VRLVEGGVGI TSVNIGGMAF RQGKTQVNNA VSVDEKDIEA FKTLNQRGIE
LEVRKVSSDS PLKMMDLIKK LGN
//
