ID A0A1J7H347_LUPAN Unreviewed; 1025 AA.
AC A0A1J7H347;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN ORFNames=TanjilG_11922 {ECO:0000313|EMBL:OIW07288.1};
OS Lupinus angustifolius (Narrow-leaved blue lupine).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC genistoids sensu lato; core genistoids; Genisteae; Lupinus.
OX NCBI_TaxID=3871 {ECO:0000313|EMBL:OIW07288.1, ECO:0000313|Proteomes:UP000188354};
RN [1] {ECO:0000313|EMBL:OIW07288.1, ECO:0000313|Proteomes:UP000188354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Tanjil {ECO:0000313|Proteomes:UP000188354};
RC TISSUE=Whole plant {ECO:0000313|EMBL:OIW07288.1};
RX PubMed=27557478; DOI=10.1111/pbi.12615;
RA Hane J.K., Ming Y., Kamphuis L.G., Nelson M.N., Garg G., Atkins C.A.,
RA Bayer P.E., Bravo A., Bringans S., Cannon S., Edwards D., Foley R.,
RA Gao L.L., Harrison M.J., Huang W., Hurgobin B., Li S., Liu C.W.,
RA McGrath A., Morahan G., Murray J., Weller J., Jian J., Singh K.B.;
RT "A comprehensive draft genome sequence for lupin (Lupinus angustifolius),
RT an emerging health food: insights into plant-microbe interactions and
RT legume evolution.";
RL Plant Biotechnol. J. 15:318-330(2017).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00006936}.
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DR EMBL; CM007368; OIW07288.1; -; Genomic_DNA.
DR RefSeq; XP_019452109.1; XM_019596564.1.
DR RefSeq; XP_019452110.1; XM_019596565.1.
DR RefSeq; XP_019452111.1; XM_019596566.1.
DR AlphaFoldDB; A0A1J7H347; -.
DR STRING; 3871.A0A1J7H347; -.
DR EnsemblPlants; OIW07288; OIW07288; TanjilG_11922.
DR GeneID; 109354219; -.
DR Gramene; OIW07288; OIW07288; TanjilG_11922.
DR KEGG; lang:109354219; -.
DR OMA; CEDAFAH; -.
DR OrthoDB; 3597773at2759; -.
DR Proteomes; UP000188354; Chromosome LG08.
DR GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd02016; TPP_E1_OGDC_like; 1.
DR Gene3D; 3.40.50.12470; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR InterPro; IPR032106; 2-oxogl_dehyd_N.
DR InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR031717; KGD_C.
DR InterPro; IPR042179; KGD_C_sf.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR PANTHER; PTHR23152:SF32; OXOGLUTARATE DEHYDROGENASE (SUCCINYL-TRANSFERRING); 1.
DR Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF16870; OxoGdeHyase_C; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000188354};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT DOMAIN 640..853
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 1025 AA; 115839 MW; F88C9B4F4DCCD794 CRC64;
MAWFRAGASI AKHVIRRTLS QGGSSYLVSR ARALPPLSNG RKLHTTVFNK KAQAAPAPHP
VPLSRLSDSF LDGTSSVYLE ELQRTWEADP SSVDESWDNF FRNFVGQSST TPGISGQTIQ
ESMRLLLLVR AYQVNGHTKA KLDPLSLEER DVSEELDLGL YGFFEADLDR EFFLGVWRMA
GFLSENRPVQ TLRSILTRLE QAYCGNIGYE YMHIADRNKC NWLRDKIETP TPIQFNRERR
EVIFDRLTWS TLFENFLATK WTSAKRFGLE GGETLIPGMK EMFDRASDLG VESIVIGMAH
RGRLNVLGNV VRKPLKQIFC EFSGGVQPED EVGLYTGTGD VKYHLGTSYD RPTRGGGRLH
LSLVANPSHL EAVNPVVIGK TRAKQYYSND VGKLKNMGIL IHGDGSFAGQ GVVYETLHLS
ALPNYSTGGT IHIVFNNQVA FTTDPSCGRS SQYCTDVAKA LDVPIFHVNG DDVEAVVHAC
ELAAEWRQTF HSDVVVDLVC YRRFGHNEID EPSFTQPKMY KVIRSHPSAL EIYQKKLLET
GELTKEDIDK IQKKVTSILN EEFMASKEYV PKRRDWLSAY WSGFKTPEQI SRIRNTGVKP
EILKNVGKAI TTLPENFTPH RAVKRIYEQR AQMIETGEDI DWGCAEALAL ATLLVEGNHV
RLSGQDVERG TFSHRHSVVH DQTTGEKYCP LDHVIMNQNE EMFTVSNSSL SEFGVLGFEL
GYSMENPNSL VIWEAQFGDF ANGAHVIFDN FLVSGESKWL RQSGLVVLLP HGYDGQGPEH
SSARLERFLQ MADDNPHVIP EMDSTLRKQI QECNLQIVNV TTPANFFHVL RRQIHREFRK
PLIVMSPKNL LRSKACRSNL SEFDDVQGHP GFDKQGTRFK RLIKDQNDHS DREEGIRRLV
LCSGKVYYEL DDQRTKVDAK DVAICRVEQL CPFPYDLVQR ELKRYPNAEI VWCQEEPLNM
GGYPYVLPRL ISSLKAVGRG GYEDVKYVGR APSAATATGF LKVHQKEQAE IAEKALQRDP
ISFPY
//
