ID   A0A1J7I9H9_9PEZI        Unreviewed;       807 AA.
AC   A0A1J7I9H9;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=PA domain-containing protein {ECO:0000313|EMBL:OIW23987.1};
GN   ORFNames=CONLIGDRAFT_637221 {ECO:0000313|EMBL:OIW23987.1};
OS   Coniochaeta ligniaria NRRL 30616.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Coniochaetales; Coniochaetaceae; Coniochaeta.
OX   NCBI_TaxID=1408157 {ECO:0000313|EMBL:OIW23987.1, ECO:0000313|Proteomes:UP000182658};
RN   [1] {ECO:0000313|EMBL:OIW23987.1, ECO:0000313|Proteomes:UP000182658}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 30616 {ECO:0000313|EMBL:OIW23987.1,
RC   ECO:0000313|Proteomes:UP000182658};
RG   DOE Joint Genome Institute;
RA   Jimenez D.J., Hector R.E., Riley R., Sun H., Grigoriev I.V.,
RA   Van Elsas J.D., Nichols N.N.;
RT   "Draft genome sequence of Coniochaeta ligniaria NRRL30616, a
RT   lignocellulolytic fungus for bioabatement of inhibitors in plant biomass
RT   hydrolysates.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC       {ECO:0000256|ARBA:ARBA00005634}.
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DR   EMBL; KV875105; OIW23987.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J7I9H9; -.
DR   STRING; 1408157.A0A1J7I9H9; -.
DR   InParanoid; A0A1J7I9H9; -.
DR   OrthoDB; 67337at2759; -.
DR   Proteomes; UP000182658; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd08022; M28_PSMA_like; 1.
DR   CDD; cd02121; PA_GCPII_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007484; Peptidase_M28.
DR   InterPro; IPR039373; Peptidase_M28B.
DR   InterPro; IPR007365; TFR-like_dimer_dom.
DR   InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR   PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR   PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   Pfam; PF04253; TFR_dimer; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182658};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          201..289
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          395..581
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
FT   DOMAIN          682..807
FT                   /note="Transferrin receptor-like dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF04253"
FT   REGION          272..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   807 AA;  89677 MW;  3E27FC748EB4C047 CRC64;
     MSSEHTPLLT TVRLGPPRRR YPHNVLRRFC TIALSSTLIW FLLAVFVALL FDPDATHYRP
     PHRHEHDEWT WPGCRGRKIT YEQLKQILLD TPDSKKAEEW SRYYTAGAHM AGQNYSQAVW
     TKEKWEEFGV KSEINTYDVY LNRPVDHRLA LLHKTEKKGG VSEWKVAYEA SLKEDVLDDD
     PTTGLKNSIP TFHGYSASGN VTAPIIYVNY GTYQDFEDLL KANVSLAGKI AIARYGGIFR
     GLKVKRAQEL GMIGTILYTD PGDDGDITEE KGLKKYPEGP ARQASSVQRG STEFLSIMPG
     DPTTPGYPSK PGVPRAPTES VIPVIPSIPI SYQDALPILK ALNGHGPKAK DFNQYWTRNA
     GLGYRGVDYN IGPTPDDVVV NLYNEQDYIT TPIWNVIGVI NGTIPDEVVV VGNHRDAWIV
     GGAGDPNSGS AVINEAIRAF GKAVEAGWKP LRTIVFASWD GEEYGLVGST EWVEEYLPWL
     TQANVAYVNI DVGVRGKEFD AKAAPLLNKL IYEVTAQVPS ANQTVPGQTV ADLWSGRIGT
     MGSGSDFTAF QDFAGVPSID VGFGGSRDDA VYHYHSNYDS FYWMSHYGDP GFVYHRTMAQ
     VLALLTARLA DSLVVPFGAK DYADALGEYV RKVQDALHDR DSASDAAVDI ANSSEEEIFA
     LRSREGDASV SAAGVFDSEE ESFARLDKAV WKLSKAAIAL DARAAELEER ARGEVPWWKW
     PRRIRLGLQI RGVNTRYKLL ERKFLHAEGL DGRGWFKHIV FAPGLWTGYA GAVFPGLMEA
     IDQKDEVRFK KWIDITERAI LRAAESL
//