ID A0A1J7IDB4_9PEZI Unreviewed; 4892 AA.
AC A0A1J7IDB4;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:OIW25405.1};
GN ORFNames=CONLIGDRAFT_691398 {ECO:0000313|EMBL:OIW25405.1};
OS Coniochaeta ligniaria NRRL 30616.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Coniochaetales; Coniochaetaceae; Coniochaeta.
OX NCBI_TaxID=1408157 {ECO:0000313|EMBL:OIW25405.1, ECO:0000313|Proteomes:UP000182658};
RN [1] {ECO:0000313|EMBL:OIW25405.1, ECO:0000313|Proteomes:UP000182658}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 30616 {ECO:0000313|EMBL:OIW25405.1,
RC ECO:0000313|Proteomes:UP000182658};
RG DOE Joint Genome Institute;
RA Jimenez D.J., Hector R.E., Riley R., Sun H., Grigoriev I.V.,
RA Van Elsas J.D., Nichols N.N.;
RT "Draft genome sequence of Coniochaeta ligniaria NRRL30616, a
RT lignocellulolytic fungus for bioabatement of inhibitors in plant biomass
RT hydrolysates.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KV875102; OIW25405.1; -; Genomic_DNA.
DR STRING; 1408157.A0A1J7IDB4; -.
DR InParanoid; A0A1J7IDB4; -.
DR OrthoDB; 1778695at2759; -.
DR Proteomes; UP000182658; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 6.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 6.
DR SMART; SM00823; PKS_PP; 5.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000182658}.
FT DOMAIN 537..610
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1604..1681
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2161..2234
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3236..3317
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3787..3863
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4348..4421
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4892 AA; 539627 MW; 80FAD6D071D72109 CRC64;
MKATPESEAA APLAILNHPP TRLPGPEYLH DLVRLSGNTQ NAAIEYLSTD GDRVSISYED
LHCLSDSLAQ RLIVLRQQQQ SDTDQFVVPV LAPQHPNLYV AILAILKAGG AFCPLNLDAP
LERVKFILKD VAATIILTTS DYISAIPADD SLAVLLLDEE PCQGVSIQSR PRRPKTTDLA
YVMYTSGSTG TPKGVGVSHE AATQSLLAHD RHIPQFSRFL QFAAPTFDVS VFEIFFPLFR
GSTLIACDRA RMLDDLPSLI RTMHIDACEL TPSVAGSLLR KRENAPCLKL LLTIGEMLTK
PVVDEFGGDD AQPSMLWAMY GPTEAAIHCT LQPALAKDSS VGNIGIPLDT VSAFILDIPE
DTNADKTRRL LAVGEVGELA VGGYQLANGY INRPETTSSA FIDSPYGPLY RTCDKARILP
DGTIECLGRI GGGQVKLRGQ RIELGEIEQV ALRTSGCHGA MAAVIGGILV LFCAVDVLNN
MDIEIRNTCE AWLPSFMVPG DIVTFTEFPI LPSGKVNRRQ LISDYALRQE QPHHTTEFKD
LTEQTLCRLA GNVLGCDIRP STNLPAAGLD SLVAIKFTSA LRQAGFELSA VDVLRSRSIS
QLHQLIAHVR ENTADQPATT ANGDTLSKDI DIESIPILHT SLHDVEEVLP CTFLQSAMLA
ETASNPQAYC NWLELSVTGK HDITEICSWI AETARRNTIL RTGFVLHDGD FTQILWKDPS
TIPILTVDHL TRDFNIITEE DFLHPLRVQI CAEEDELRVL LQIHHSLYDG WTSDLLLSDM
NALSKGKQLE SRPQFRAVAD YCQSKAFTEQ CDLARRFWAE GLASFQSNPF PNLLDVPPHQ
SQIESRIVSV AFKPRSARRT LQEIECSPQV LFQAALAWIW SSLVGDEDII TGFVTSGRTI
PVAGIEQVMG PCIATLPLRT NLSQTRTVKD LLASIQAWNR SALSHTSLPL GEIKKAAGIA
PGQSLYDVLF VYQESLYSPP TDADCIREVA HLDYLETKLL VEVEPKQDYY ECRLTYHTDA
FSDAHIALLI QEIQCVARHM LENIDSELVS TTTAFPEQIL STYNLEPQSF TGTPDLVLTV
ENVVSCTPDK TALCFASRIA GDSADAEYVS YREFNSMANK IARHIRSSDC STGDVVSIVM
EKSVLLYAGI LGILKAGCSY LPLLPSTPIA RMEVIHSQAN VSLCLTDNSA SAALSQLLGH
QFHITNLDQV DLQRMDDTNL NIPADPARIA VIVYTSGSTG VPKGVCVTQL NVASNIDVLS
KIYPVKENSR LLQSCSQAFD VSVFEMFFTW TQGMTLCSAT NDTLFEDIER SIRTLKVTHL
SMTPTVASLI DPKKVPMVDF LVTSGEPMTE KVARSWWRQL YQGYGPSETT NICTVKKMGP
NDVIQHLGYS FGNTSTVVLF LNGSEAVPRG CLGELCFGGD QVAQGYLNMP ELTAAKFIDH
PKFGRLYRSG DIGRMLPDGS LVITGRVDDQ IKLRGQRIEL SEINAIIRQS NIVSDCLTLL
VNRENPSAMQ LASFYVPQDS ADIAISKVMP LDDRLKDITA SIFRLLASKL PSYMVPSYLV
PVSKLPLTAS GKLDRAWFIE TFHKLGQSYL EMTASNIQTD QDDGEWNETE RKVADIVSSV
LSTGGLSINR WAPLVSFGLD SISAISLSRR LHKQFGRRIP VSLILQNSCV AHLAHAVDDL
GLEQDRDSIS LEIFSGEWID TLKSKCQSQG KVVENILPCT PLQEAMLAAS ANGKSYLNNM
LFRLHADPAA VKGYWATMCE RQSILRTCFA ATEMPHHAFA QVILHGWQPK WLHFDEAQGD
LDECVSQHLA RHTDAVDSWE PPVSFAIIRQ GEQLYLSFVC HHALYDGNAI ELLLHEVEQL
ADGIALETPP AIEPFLRAML ADSPTSNDFW NEQLLNFGPV ELPTSRSPAT EKSSTTHDIY
SAHINIKLSD ISERTKNVGC SLLSVCQAAW TLVLTTILEV DDVCFGNVVS CRSVDVEGIE
KLVAPCFNTV PIRASLSNIR RNIDLIKALS ALSPQVIQHQ FTSLRRIQSL AFPGEVKRLF
DTLLILQQPA RSLDHRIWSL ERDDGEMDIP LVCEFRPDTQ HDVLLVQLHY ECSRISKPFI
DLISDLLQHC MSACLRYPSS QIPTRSSLPP SIAARLLELD LQRNSPVVTE IVTGQNGEDW
SPVESRIRAV LAKLSSLPEQ NIRRTTTIYQ LGLDSINAVQ IASLLRKQGM AISASDVIVQ
KTCANLAKKA VKQEDAPSQA YQYDFSGYRR RAESQLGQHG ISKELVDTVL PCTSLQAGMI
VQFVQSKGHD YFNYIDFQLD EDIELHTLTN AWAKISDSHA MLRTGFIPVD DAEFPYAMVQ
YSTSAIRETV SLVNSKTAPR WSIDKWRLDM ADEVLNNLQI PPWRVVCVDH DGGPMMHLAA
HHALYDAQSL QRMLEDLAQT LRGEPLGPDP AIEEVVKDII TQGSHAERQE AFWKAQSDQV
VINHFPTLTP LRVDSKRMIV ESTVSNQKFT EIEQSLGNSG FTVQAGLQAA WTRILSSYLG
ESSVTFGIVL SGRNSEATQD AVFPCISTVP VISVNKSSNR ELLQAMLAYS SHVYQNQHIP
LNKIQRWLGY PEGRVFDTLL VYQKLARSSD TSLPWKVVND QGTVDYPVSI EVEPSANDTL
VYRMTSSSDV VPVEHAKLLL EQFDAVFCDL ALRPDGYEDD LFSRASSLFS CTPAEEPQVY
CKEDFLHQLV ESQALKDPNK TALEFVSGFQ GARPISKTWS YRSLDENGNR VARMLQRYVK
TGATVAVLFD KCPEAFFSIL GVLKAGCAFV ALDPGSPPSR KQFILEDSRA SVLLTSSDLE
KSLGFSTDVP HIVIDEASLL KQDGNPVILE PKITPQHTCY CLYTSGTTGT PKGCEITHEN
AVQAMLAFQR LFVGHWDETS KWLQFASFHF DVAVLEQYWS WSVGIILTAA PRDLILEDLA
GTISRLEITH IDLTPSLARL IHPDEVPSLT RGVFITGGEQ LKQEILDAWG SKSVIYNAYG
PTEATIGVTT YSRVPQNGRP SNIGKQFVNV GTYVLKPGTE TPVLRGGMGE LCVSGKLVGK
GYLGRDDLTA ERFPTLKQFN ERVYRTGDLV RILHDGCFDF LGRADDQVKL RGQRLELGEI
NHIIRSGVSA VTDVATLVVR NEKQRKDVLV TFVGTGKHSS LVEDIQVLDS PEAADLAQRV
QSACRDRLPP YMVPTYVLVL PFIPLSSNNK AETRKLKKLF VDMDHAQLMS LMKPASEPTI
GLNEVGREVL RVLSAIATFP TQEVDSSTTI FDFGIDSISA MRFSTALKRA GFPQASPSLI
LTHPRLGDLA SQLSQKRAPA GKNHTLAARQ LVQACHHKYR ALVEKELDLD AADIEYIAPC
SPLQEGMISR SNMPLAAGAY FNTFQYKLSS QVSSLQLRKA WTKLVESCSV LRTRFLRTTD
GYVQVATKVT TIPWTEFCLA SESDLEALVK EKQQFWIERN TVHVKQPLDL MTISIGEETK
YLVVNISHGI YDAMSLDIML DRLLGYYLEV PVSSSAPSYL EALVHGPLRS FNESKGFWVE
HLKSALHQKC PVLCKQPSSE SLTYDRLVPV GDLESLRTAL GVTHQAILQA VWVSVYQQFL
ENVTIGVVIS GRSIDLEGAD AVIGPLFNTI AFHPSLAPGE TWASLIKQCH NYNVSIIPFQ
HIALRDVQKW CSGGKPLFDT LFSFQRAADK PAHDQLWTLL ESPPNPDYAL AFEAMLTSDG
HLRLQLVTKA GIADMHTLSM LLDQVEVALQ SVLTPELPIP LTSHHGSQVT QNGAESLEQT
TQKLDSFEWT ETALTIRDEI ASLADIPADS LTATTSLLEL GLDSIDLIKL SSRLRSRGIG
ITSGQLMRDG AISAMVQHLE QGDSNTAHAS NDTRSIHSTS EAIKEYLLCA GFDIHEAEDV
LPVTPLQDSM IAEMVQSDFH RYFNHDVLAL DPAIDTYRLL QAWEQVVVSS PILRTTFLRI
DSPKFDAAYC QVISKSLPLV LQGATVTGEN EFPQVMESAR QRACEEAGRA NLLQLTLVNV
NTRRYLVLSI AHALYDGWSL GLLHQDVQTA YYESYVPRLP YKEYLTQIIT ASTSEAKQFW
SGFLAGAHAT FIPQGKVMNV DGEEEMYRID TASSIPLAAI RDFCRRYAVS IQVLGQACWA
AILGSHTKCL DVTFGVVLSG RDTVEAEELL FPTMNTVAVR SIIHGGIVSW LRYMQENMTN
ISSFQHYPLR DALKLAGTQR GPLFNSLFIQ QRAQEPIFDK KVPWMASVGG DSAVEYPICV
EVEISDEQLM WRAACNSGYM SRKDTVKLIH HLDSVLGYLV NSPAADVISF EGGNVSICGL
PSFELSDSPS DVTDFAVTNE VEDANTWSET ENLIRSAVSE VSGVPLSSIS KKHTIYHLGL
DSISTIKVSS LLRKRGVALS VRQILGAASI QEMIVITTAK TAADGVGTHA VSRNGTTTDD
GAAQDSIDNI TACLRSVDAA AVLIDAGVSE ELVEEVLPAT AMQVHMLSVW QNTSGVVFFP
EFTYSLQGGV DVDDIRSAWL ALVEHQPILR TSFLATGLRH VPFLQVIQRY RPELSNIMVR
QGAVESEIKG TVSEPLVSLH ANYVGKDHWR LKLKIHHALY DGISLPALTE SFRQLCQEKW
LSSQVSEKTQ LSRKTFWTEY LKGVKTPPFQ ARTASPSSAK TRTSLFEHAA VKDTAKLQTI
CAAFGVSLQA LFFAAYAKFL APGVVGRDDI VCGMYLANRT SIDGLDRLPY PTLSLVPLRV
RQPASRDVVA VAKSIQADLY EISSPANASV GLWEIFDWTG LKIDSFVNFL SLPDSHSTDG
TDGIVLREAS DNDIAVQSQT RPGLSPEDQR LLTSNSVRDA YPDAVDIEVS VTGSLMNIGV
FGPTEMVDTA GAAEIVSGIV RALTTVHDVL GK
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