ID   A0A1J7IMY3_9PEZI        Unreviewed;       760 AA.
AC   A0A1J7IMY3;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN   ORFNames=CONLIGDRAFT_719858 {ECO:0000313|EMBL:OIW22481.1};
OS   Coniochaeta ligniaria NRRL 30616.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Coniochaetales; Coniochaetaceae; Coniochaeta.
OX   NCBI_TaxID=1408157 {ECO:0000313|EMBL:OIW22481.1, ECO:0000313|Proteomes:UP000182658};
RN   [1] {ECO:0000313|EMBL:OIW22481.1, ECO:0000313|Proteomes:UP000182658}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 30616 {ECO:0000313|EMBL:OIW22481.1,
RC   ECO:0000313|Proteomes:UP000182658};
RG   DOE Joint Genome Institute;
RA   Jimenez D.J., Hector R.E., Riley R., Sun H., Grigoriev I.V.,
RA   Van Elsas J.D., Nichols N.N.;
RT   "Draft genome sequence of Coniochaeta ligniaria NRRL30616, a
RT   lignocellulolytic fungus for bioabatement of inhibitors in plant biomass
RT   hydrolysates.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR   EMBL; KV875113; OIW22481.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J7IMY3; -.
DR   STRING; 1408157.A0A1J7IMY3; -.
DR   InParanoid; A0A1J7IMY3; -.
DR   OrthoDB; 2712461at2759; -.
DR   Proteomes; UP000182658; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   Gene3D; 6.20.120.20; -; 1.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022955};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022955};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182658};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Steroid biosynthesis {ECO:0000256|ARBA:ARBA00022955}.
FT   DOMAIN          114..317
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          420..750
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   760 AA;  87368 MW;  5E02884E3C59B57D CRC64;
     MAKRKSNDIA TGAEVAVNGG AGQIKARNPK AYQNGNDVVH DTKRPRLEER TDYTRWRMRD
     DESRHTWHYL EDDEAMKEWP QTFADKYYLG LPLDLPKLPR AKRPLDAVRN GLEFFEKLQL
     PSGHWGCEYG GPMFLLPSVV MAWHATKTPI PWYYATEIKN YLFNRTHPDD GGWGLHIEAD
     SSVFGTAMNY VTLRLVGVDA DHPKMVRARA TLHKLGGATH GPHWLKFWLS VLGVAKWDIV
     NPIPPELWLL PDWVPFAPWR WWIHIRQVFI AMSFLWSKRW VAEETDVIRS LRKELFVEPW
     EEIDWVGNRN TIAKEDNYHP KSGLLNLLNT LLVNIWNPYL RTNALAKLAE NRVSELIDME
     DANTDYADLA PVNGSMNLVV CYARDGPDSY SVKRHRERVH EYLWVNKDGL HCNGTNGVQC
     WDTAFAIQTI MDAGLTEDPR YRPMLLKALK YLDSQQIREN VENQSKCYRQ QRKGGWAFSN
     KDQGYAVSDC VSEALKSVII LQKTPGFPTL IDDRRIFDAI DTLLTYQNPS GGCSSYEPAR
     AGEWMEILNT AEVFGRIMVE YEYPECTTAV VTALSLFHKH WPDYRAKDID LFVERAVKWI
     KTAQRPDGSW YGSWGICFTY AGMFALESLS GVGETYETSS SSKRGCDFLI SKQRPDGGWS
     ESYKSCEQMV YTEHPTGSQV VMTAWALIGL MKANYPDPEP IRRGIKLIME RQQPNGEWLQ
     EAIEGVFNKS CMIWYPNYKL VFTMKALGMF AKKYPKETVV
//