ID   A0A1J7IXA0_9PEZI        Unreviewed;       690 AA.
AC   A0A1J7IXA0;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=3-isopropylmalate dehydratase {ECO:0000313|EMBL:OIW25705.1};
GN   ORFNames=CONLIGDRAFT_708439 {ECO:0000313|EMBL:OIW25705.1};
OS   Coniochaeta ligniaria NRRL 30616.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Coniochaetales; Coniochaetaceae; Coniochaeta.
OX   NCBI_TaxID=1408157 {ECO:0000313|EMBL:OIW25705.1, ECO:0000313|Proteomes:UP000182658};
RN   [1] {ECO:0000313|EMBL:OIW25705.1, ECO:0000313|Proteomes:UP000182658}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 30616 {ECO:0000313|EMBL:OIW25705.1,
RC   ECO:0000313|Proteomes:UP000182658};
RG   DOE Joint Genome Institute;
RA   Jimenez D.J., Hector R.E., Riley R., Sun H., Grigoriev I.V.,
RA   Van Elsas J.D., Nichols N.N.;
RT   "Draft genome sequence of Coniochaeta ligniaria NRRL30616, a
RT   lignocellulolytic fungus for bioabatement of inhibitors in plant biomass
RT   hydrolysates.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KV875101; OIW25705.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J7IXA0; -.
DR   STRING; 1408157.A0A1J7IXA0; -.
DR   InParanoid; A0A1J7IXA0; -.
DR   OrthoDB; 1326656at2759; -.
DR   Proteomes; UP000182658; Unassembled WGS sequence.
DR   GO; GO:0016836; F:hydro-lyase activity; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1901607; P:alpha-amino acid biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR   Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR   InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR   InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   InterPro; IPR011827; LeuD_type2/HacB/DmdB.
DR   NCBIfam; TIGR02087; LEUD_arch; 1.
DR   PANTHER; PTHR43822:SF2; 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR43822; HOMOACONITASE, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF00330; Aconitase; 2.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   PRINTS; PR00415; ACONITASE.
DR   SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182658}.
FT   DOMAIN          92..307
FT                   /note="Aconitase/3-isopropylmalate dehydratase large
FT                   subunit alpha/beta/alpha"
FT                   /evidence="ECO:0000259|Pfam:PF00330"
FT   DOMAIN          313..432
FT                   /note="Aconitase/3-isopropylmalate dehydratase large
FT                   subunit alpha/beta/alpha"
FT                   /evidence="ECO:0000259|Pfam:PF00330"
FT   DOMAIN          545..600
FT                   /note="Aconitase A/isopropylmalate dehydratase small
FT                   subunit swivel"
FT                   /evidence="ECO:0000259|Pfam:PF00694"
FT   REGION          669..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   690 AA;  74886 MW;  AE898AAAA8E3E5B4 CRC64;
     MADATAQETG LNACEKVLIH HAVGLSSTPS YIPTDQVLLL KPSWLLCSEA AWNSMEPNYN
     ALGRPSFRRK DRFWLAPDHM VDPRVNHRPR EKAIIEKCER IARDMNLGDN YNPPNTTIMH
     TDFYRKRCQP GQLVVGADSH TGSAGSLGAL AIGMGITDVL MQVVTGETFL KMPEVICIRL
     VGRPPLGLGG KDVIMGVLGQ LKRNTVAAER LVEFVGEGLR WLSCDARFAI CNMVTELGGI
     GALVVPDAVT AEYIARRPER RHKSDAVFFK PDANARYAGE YKIDLSELEH CVALYPSPDN
     VVPVSQAELP ELQGCFIGAC TTTEEDLILA GLVLREGLKA GLRPVSRGLR RVTPGSVDIT
     EKLRRLGLID VYQEAGFTVG APGCSYCVGM GIDKAGRGEV WLSSQNRNYR DRMGPGSIAN
     LASAATVAAS SFSMTLQSPQ QLLDQIDFTE YDRLREYYSP SMDQVADPTY SEPSPVMPPS
     QAQQESVISS LPSLICGRIQ RFGDNVDTDS IAPTEICLGS PTPEALARGA FCHTRPEFHE
     RARAGATVVV AGTAFGTGSS REQAPKVLLA AGIQAVVARS FAFIYGRNQA NSGLLGVKVR
     DDRFYELAGE GVEVEIDVEG RVVVCGGERF GFRLDAIEER LIAAGGLLKM YDLHGNALFQ
     YLQDAVSTGT GPTDGTVDRA ETRGDGRLEW
//