ID A0A1J7JAB4_9PEZI Unreviewed; 355 AA.
AC A0A1J7JAB4;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 08-NOV-2023, entry version 18.
DE RecName: Full=Porphobilinogen deaminase {ECO:0000256|ARBA:ARBA00016519};
DE EC=2.5.1.61 {ECO:0000256|ARBA:ARBA00012655};
DE AltName: Full=Hydroxymethylbilane synthase {ECO:0000256|ARBA:ARBA00033064};
DE AltName: Full=Pre-uroporphyrinogen synthase {ECO:0000256|ARBA:ARBA00030685};
GN ORFNames=CONLIGDRAFT_654475 {ECO:0000313|EMBL:OIW30241.1};
OS Coniochaeta ligniaria NRRL 30616.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Coniochaetales; Coniochaetaceae; Coniochaeta.
OX NCBI_TaxID=1408157 {ECO:0000313|EMBL:OIW30241.1, ECO:0000313|Proteomes:UP000182658};
RN [1] {ECO:0000313|EMBL:OIW30241.1, ECO:0000313|Proteomes:UP000182658}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 30616 {ECO:0000313|EMBL:OIW30241.1,
RC ECO:0000313|Proteomes:UP000182658};
RG DOE Joint Genome Institute;
RA Jimenez D.J., Hector R.E., Riley R., Sun H., Grigoriev I.V.,
RA Van Elsas J.D., Nichols N.N.;
RT "Draft genome sequence of Coniochaeta ligniaria NRRL30616, a
RT lignocellulolytic fungus for bioabatement of inhibitors in plant biomass
RT hydrolysates.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=dipyrromethane; Xref=ChEBI:CHEBI:60342;
CC Evidence={ECO:0000256|ARBA:ARBA00001916};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
CC {ECO:0000256|ARBA:ARBA00004735}.
CC -!- SIMILARITY: Belongs to the HMBS family.
CC {ECO:0000256|ARBA:ARBA00005638}.
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DR EMBL; KV875097; OIW30241.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J7JAB4; -.
DR STRING; 1408157.A0A1J7JAB4; -.
DR InParanoid; A0A1J7JAB4; -.
DR OrthoDB; 788at2759; -.
DR UniPathway; UPA00251; UER00319.
DR Proteomes; UP000182658; Unassembled WGS sequence.
DR GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd13645; PBP2_HuPBGD_like; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR Gene3D; 3.30.160.40; Porphobilinogen deaminase, C-terminal domain; 1.
DR HAMAP; MF_00260; Porphobil_deam; 1.
DR InterPro; IPR000860; HemC.
DR InterPro; IPR022419; Porphobilin_deaminase_cofac_BS.
DR InterPro; IPR022417; Porphobilin_deaminase_N.
DR InterPro; IPR022418; Porphobilinogen_deaminase_C.
DR InterPro; IPR036803; Porphobilinogen_deaminase_C_sf.
DR NCBIfam; TIGR00212; hemC; 1.
DR PANTHER; PTHR11557; PORPHOBILINOGEN DEAMINASE; 1.
DR PANTHER; PTHR11557:SF0; PORPHOBILINOGEN DEAMINASE; 1.
DR Pfam; PF01379; Porphobil_deam; 1.
DR Pfam; PF03900; Porphobil_deamC; 1.
DR PIRSF; PIRSF001438; 4pyrrol_synth_OHMeBilane_synth; 1.
DR PRINTS; PR00151; PORPHBDMNASE.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF54782; Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain; 1.
DR PROSITE; PS00533; PORPHOBILINOGEN_DEAM; 1.
PE 3: Inferred from homology;
KW Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000182658};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..231
FT /note="Porphobilinogen deaminase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01379"
FT DOMAIN 247..320
FT /note="Porphobilinogen deaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03900"
SQ SEQUENCE 355 AA; 37686 MW; 9AC9D40FDD3FA288 CRC64;
MSTSTPSPFT LTIGTRRSGL ALKQVDLIIA SLQPHHPHIT FAVDAVATMG DVDKTTPLPN
LGKGLWTNEL EAKLLTNQVD FVVHCLKDMP TTLPAGCVLG AITEREDPRD VVVFPKGGSS
KAGRYARVAD LPEGAVVGTS SVRRAAQLKR KYPGLRFADI RGNIDTRMKK VDAEGAVYDC
TILAAAGLHR MGQHDRIAQY LDSSEEGGEM LYAVGQGALG LECREGDERV LEVLRCIDHR
PTNLAGAAER SIMRTLEGGC SVPIGVETTW VGGPGEDKLR LKATVVSLDG KQGVDGEMTA
TIRSVEEAEA LGEKLAAELV EKGAQKILDV INSARDTTAP GVGASAAVKI SNLIN
//
