ID A0A1J8P588_9COXI Unreviewed; 1175 AA.
AC A0A1J8P588;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=A1D18_04525 {ECO:0000313|EMBL:OIZ94131.1};
OS Candidatus Rickettsiella isopodorum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Rickettsiella.
OX NCBI_TaxID=1225476 {ECO:0000313|EMBL:OIZ94131.1, ECO:0000313|Proteomes:UP000183924};
RN [1] {ECO:0000313|EMBL:OIZ94131.1, ECO:0000313|Proteomes:UP000183924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCFS May 2013 {ECO:0000313|EMBL:OIZ94131.1,
RC ECO:0000313|Proteomes:UP000183924};
RA Chandler C., Wang Y.;
RT "Comparative genomics of Rickettsiella.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIZ94131.1}.
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DR EMBL; LUKY01000033; OIZ94131.1; -; Genomic_DNA.
DR RefSeq; WP_071662624.1; NZ_LUKY01000033.1.
DR AlphaFoldDB; A0A1J8P588; -.
DR STRING; 1225476.A1D18_04525; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000183924; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR048472; DNA_pol_IIIA_C.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR049821; PolIIIA_DnaE1_PHP.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF20914; DNA_pol_IIIA_C; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000183924};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..72
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1175 AA; 132778 MW; 2D57C0FD6BB31F7B CRC64;
MPSFIHLHLH TEYSLIDGLI RIDKLVAKAD ELSMPAIAIT DLSNLFATIK FYQTAIKKGI
KPIIGVECCV KNDLNSDRGF QLILLCQNQQ GYRNLIQLIS RAYLENQQEG QPVLKKSWFE
NYSAGLIALS GAREGDIASC LMKKNKPLAA EYLQFWLTLF PNRFYLQLQR LGRPLEEEYI
GLAIELATEF NVPVVATNEV CFIAAEDFEA HEARVCVNNG YTLNDPKRPT IYTDQQYLRS
IEEMVELFAD IPSALTNSVE IAKRCNLEIE LNSSFLPNFP IPEGMSAEKF LIQEAQQGLI
HYLEKRSKSF LRLSQLENKE SKLSTLTETN VAQQQLVNSN ELENIYFERL QSELKVINSM
GFASYFLIVA DFIRWAKKNQ IPVGPGRGSG AGSLVAYVLQ ITGLDPLQYD LLFERFLNPE
RISMPDFDID FCMEGRDRVI DYVTERYGRD AVSQIITYGS MAARAVVRDV GRVLGYPYGM
VDKIAKLIPF ELGITLEKAL DQEDELKHRY ENEDEIKVLI DLAKKLEGLV RNVGKHAGGV
VIAPSRLTDF TPLYCEPGGM HCITQFDKDD IEKVGLVKFD FLGLRTLTII DWAVQAINAK
KLSGESLLDI TAIPIDDVST FALLKACKTT AVFQLESRGM RDLVKRLRPD SFDEIIALVA
LFRPGPLQSG MVDDFINRKH GRAQVQYDHP FLEPILSSTY GIILYQEQVM QIAQVLAGYT
LGAADLLRRA MGKKKSEEMA QQRTIFIKGA EQKGIDSYLA NQIFDLMEKF ADYGFNKSHS
AAYALVSYQT AWLKAHYPAE FMAAVLSSDM DHTEKVVTFL EECRLMKLNI LPPNINHSDY
KFTVDDSNGS IRYGLGAIKG LGEGAIEMLI EQRQQQAFSD LFDLCHRVDL HKLNRRSLEA
LIFSGSLDSF GVNRASLLAN IEAALQAADQ KSWAKVSGQK DFFGLDMVSH ASQMVNQEDW
PKLQRLQAEK EVLGFYLSGH PLEGYAKELS HFITLSLSEL TAKAGHQITI AGWVLTIRSL
WTKRGDRMAV LNLEDASGRL EVTLFSDTYA KYREKLNKDK LLIIEGEIQR DEYTGNTRIL
GKKILDISEA RESYAKNLLI KLSKPIIKPA LLEDLQKIMS NFCPGFCPTR IAYYHPELRT
QVYLSLGDSW KVKPEDDLLK ALRESFGEES ISIQY
//
