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Database: UniProt
Entry: A0A1J8PA75_9GAMM
LinkDB: A0A1J8PA75_9GAMM
Original site: A0A1J8PA75_9GAMM 
ID   A0A1J8PA75_9GAMM        Unreviewed;       284 AA.
AC   A0A1J8PA75;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   08-MAY-2019, entry version 13.
DE   RecName: Full=Formyltetrahydrofolate deformylase {ECO:0000256|HAMAP-Rule:MF_01927};
DE            EC=3.5.1.10 {ECO:0000256|HAMAP-Rule:MF_01927};
DE   AltName: Full=Formyl-FH(4) hydrolase {ECO:0000256|HAMAP-Rule:MF_01927};
GN   Name=purU {ECO:0000256|HAMAP-Rule:MF_01927};
GN   ORFNames=QHL1GM_04455 {ECO:0000313|EMBL:OJA04699.1};
OS   Halomonas sp. QHL1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=1123773 {ECO:0000313|EMBL:OJA04699.1, ECO:0000313|Proteomes:UP000183854};
RN   [1] {ECO:0000313|EMBL:OJA04699.1, ECO:0000313|Proteomes:UP000183854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=QHL1 {ECO:0000313|EMBL:OJA04699.1,
RC   ECO:0000313|Proteomes:UP000183854};
RA   Seilhamer J.J.;
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of 10-formyltetrahydrofolate
CC       (formyl-FH4) to formate and tetrahydrofolate (FH4).
CC       {ECO:0000256|HAMAP-Rule:MF_01927}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-
CC         tetrahydrofolate + formate + H(+); Xref=Rhea:RHEA:19833,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:57454; EC=3.5.1.10;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01927};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.
CC       {ECO:0000256|HAMAP-Rule:MF_01927}.
CC   -!- SIMILARITY: Belongs to the PurU family. {ECO:0000256|HAMAP-
CC       Rule:MF_01927}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OJA04699.1}.
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DR   EMBL; MINL01000001; OJA04699.1; -; Genomic_DNA.
DR   RefSeq; WP_071693405.1; NZ_MINL01000001.1.
DR   UniPathway; UPA00074; UER00170.
DR   Proteomes; UP000183854; Unassembled WGS sequence.
DR   GO; GO:0008864; F:formyltetrahydrofolate deformylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd08648; FMT_core_Formyl-FH4-Hydrolase_; 1.
DR   HAMAP; MF_01927; PurU; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR041729; Formyl-FH4-Hydrolase_C.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR036477; Formyl_transf_N_sf.
DR   InterPro; IPR004810; PurU.
DR   PANTHER; PTHR42706; PTHR42706; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   PRINTS; PR01575; FFH4HYDRLASE.
DR   SUPFAM; SSF53328; SSF53328; 1.
DR   TIGRFAMs; TIGR00655; PurU; 1.
DR   PROSITE; PS51671; ACT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000183854};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01927};
KW   One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_01927};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01927}.
FT   DOMAIN        6     86       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   ACT_SITE    228    228       {ECO:0000256|HAMAP-Rule:MF_01927}.
SQ   SEQUENCE   284 AA;  32140 MW;  AE16843C704A52B6 CRC64;
     MSHFYRLVVS CPDQVGIVAR VSSFIAQQGG SITEASQHSD LETGCFFMRY EILADSVGMS
     VEALRTAFEP VASEFNMQWS LVDTQQRRRV VLMVSRESHC LVDLLYRWQA GELDCDIVGV
     ISNHDDMRSL TEWYGIPYHH VPVDRDNKQA SFAKVQAEID SARADCVVLA RYMQILPPEL
     CARYAGRVIN IHHSFLPSFA GAKPYHQAYQ RGVKLIGATC HYVTEELDAG PIIEQDIHRV
     SHCHTPTDLV RFGRDVEKAV LARGLRWHLE DRVLVHGNKT VVFS
//
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