ID A0A1J8PCU5_9COXI Unreviewed; 336 AA.
AC A0A1J8PCU5;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 08-NOV-2023, entry version 18.
DE RecName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011990, ECO:0000256|RuleBase:RU004473};
DE EC=4.2.1.46 {ECO:0000256|ARBA:ARBA00011990, ECO:0000256|RuleBase:RU004473};
GN ORFNames=A1D18_03475 {ECO:0000313|EMBL:OIZ95167.1};
OS Candidatus Rickettsiella isopodorum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Rickettsiella.
OX NCBI_TaxID=1225476 {ECO:0000313|EMBL:OIZ95167.1, ECO:0000313|Proteomes:UP000183924};
RN [1] {ECO:0000313|EMBL:OIZ95167.1, ECO:0000313|Proteomes:UP000183924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCFS May 2013 {ECO:0000313|EMBL:OIZ95167.1,
RC ECO:0000313|Proteomes:UP000183924};
RA Chandler C., Wang Y.;
RT "Comparative genomics of Rickettsiella.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose
CC + H2O; Xref=Rhea:RHEA:17221, ChEBI:CHEBI:15377, ChEBI:CHEBI:57477,
CC ChEBI:CHEBI:57649; EC=4.2.1.46;
CC Evidence={ECO:0000256|ARBA:ARBA00001539,
CC ECO:0000256|RuleBase:RU004473};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911,
CC ECO:0000256|RuleBase:RU004473};
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. dTDP-glucose dehydratase subfamily.
CC {ECO:0000256|ARBA:ARBA00008178, ECO:0000256|RuleBase:RU004473}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIZ95167.1}.
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DR EMBL; LUKY01000032; OIZ95167.1; -; Genomic_DNA.
DR RefSeq; WP_071662427.1; NZ_LUKY01000032.1.
DR AlphaFoldDB; A0A1J8PCU5; -.
DR STRING; 1225476.A1D18_03475; -.
DR OrthoDB; 9803010at2; -.
DR Proteomes; UP000183924; Unassembled WGS sequence.
DR GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR CDD; cd05246; dTDP_GD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR01181; dTDP_gluc_dehyt; 1.
DR PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU004473}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000183924}.
FT DOMAIN 9..326
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 336 AA; 38375 MW; 74D0A801BD356424 CRC64;
MMYTPKNVLV TGGAGFIASH FVKYSQVYYP EIFIVNLDKL TYAGSLNNLK NLDLPAQHRF
VQGDILNSYL VLNLLREFKV DTVVHFAAET HVDRSINTPE EFIRTNISGT FVLLDSCRKY
WLEEQGLSKF ACRFHHISTD EVYGSLQKDD PAFTELMPYR PNSPYSASKA SSDYLVRAYY
NTYGLPITIT NCSNNYGPYQ HNEKLIPTII DSCLRQKPIP VYGDGSNIRD WLFVEDHCSG
IDRVIRNGKL GESYNVGGNT ELTNLEVIEV ICEILSNVRP VSYKYLDLIT FIKDRPGHDL
RYAINAEKIS KELNWQPKET FSTGILKTLM AYSQIK
//
