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Database: UniProt
Entry: A0A1J8PDG0_9GAMM
LinkDB: A0A1J8PDG0_9GAMM
Original site: A0A1J8PDG0_9GAMM 
ID   A0A1J8PDG0_9GAMM        Unreviewed;       132 AA.
AC   A0A1J8PDG0;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=6-carboxy-5,6,7,8-tetrahydropterin synthase {ECO:0000256|ARBA:ARBA00018141};
DE            EC=4.1.2.50 {ECO:0000256|ARBA:ARBA00012982};
DE   AltName: Full=Queuosine biosynthesis protein QueD {ECO:0000256|ARBA:ARBA00031449};
GN   ORFNames=QHL1GM_17510 {ECO:0000313|EMBL:OJA07061.1};
OS   Halomonas sp. QHL1.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=1123773 {ECO:0000313|EMBL:OJA07061.1, ECO:0000313|Proteomes:UP000183854};
RN   [1] {ECO:0000313|EMBL:OJA07061.1, ECO:0000313|Proteomes:UP000183854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=QHL1 {ECO:0000313|EMBL:OJA07061.1,
RC   ECO:0000313|Proteomes:UP000183854};
RA   Seilhamer J.J.;
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7,8-dihydroneopterin 3'-triphosphate + H2O = 6-
CC         carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) +
CC         triphosphate; Xref=Rhea:RHEA:27966, ChEBI:CHEBI:15343,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC         ChEBI:CHEBI:58462, ChEBI:CHEBI:61032; EC=4.1.2.50;
CC         Evidence={ECO:0000256|ARBA:ARBA00001293};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- PATHWAY: Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005061}.
CC   -!- SIMILARITY: Belongs to the PTPS family. QueD subfamily.
CC       {ECO:0000256|ARBA:ARBA00008900}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OJA07061.1}.
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DR   EMBL; MINL01000001; OJA07061.1; -; Genomic_DNA.
DR   RefSeq; WP_064234589.1; NZ_MINL01000001.1.
DR   AlphaFoldDB; A0A1J8PDG0; -.
DR   STRING; 1123773.QHL1GM_17510; -.
DR   OrthoDB; 9787853at2; -.
DR   UniPathway; UPA00391; -.
DR   Proteomes; UP000183854; Unassembled WGS sequence.
DR   GO; GO:0070497; F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.479.10; 6-pyruvoyl tetrahydropterin synthase/QueD; 1.
DR   InterPro; IPR007115; 6-PTP_synth/QueD.
DR   InterPro; IPR038418; 6-PTP_synth/QueD_sf.
DR   PANTHER; PTHR12589:SF7; 6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE; 1.
DR   PANTHER; PTHR12589; PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE; 1.
DR   Pfam; PF01242; PTPS; 1.
DR   SUPFAM; SSF55620; Tetrahydrobiopterin biosynthesis enzymes-like; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
SQ   SEQUENCE   132 AA;  14606 MW;  6126058A467F4DE6 CRC64;
     MFRLCVRDHF MIAHSFNGEI FGPAQRTHGA TYVVDVVFQR PELDEDGLVI DIGLASETVK
     SVLADYNFSN LDEVPEFAGK NTTTEFMAKV IFDQLAKAIG EGKMGITAKG ITHMEIKLHE
     SHVAWASYEG AL
//
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