ID A0A1J8PJM1_9AGAM Unreviewed; 2073 AA.
AC A0A1J8PJM1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=AZE42_01077 {ECO:0000313|EMBL:OJA07995.1};
OS Rhizopogon vesiculosus.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Boletales; Suillineae; Rhizopogonaceae; Rhizopogon.
OX NCBI_TaxID=180088 {ECO:0000313|EMBL:OJA07995.1, ECO:0000313|Proteomes:UP000183567};
RN [1] {ECO:0000313|EMBL:OJA07995.1, ECO:0000313|Proteomes:UP000183567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AM-OR11-056 {ECO:0000313|EMBL:OJA07995.1,
RC ECO:0000313|Proteomes:UP000183567};
RA Mujic A.B., Kuo A., Tritt A., Lipzen A., Chen C., Johnson J., Sharma A.,
RA Barry K., Grigoriev I.V., Spatafora J.W.;
RT "Comparative genomics of the ectomycorrhizal sister species Rhizopogon
RT vinicolor and Rhizopogon vesiculosus (Basidiomycota: Boletales) reveals a
RT divergence of the mating type B locus.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJA07995.1}.
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DR EMBL; LVVM01006478; OJA07995.1; -; Genomic_DNA.
DR STRING; 180088.A0A1J8PJM1; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000183567; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0019219; P:regulation of nucleobase-containing compound metabolic process; IEA:UniProt.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF124; SERINE_THREONINE-PROTEIN KINASE MEC1; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000183567};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1025..1580
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1708..2018
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2041..2073
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 46..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2073 AA; 233374 MW; 4FC7C5BC4B015DDB CRC64;
MELLRSETWG SSGSELRALA VLYIRGCVSR LDPVSSQAAQ SFLQGNASNC PDSEPLPITQ
AAGTPTGSPM EEDTGSVDTS HWRAALQNIV STLITPDQLQ WKGFEHDDAT SFYIQRILDA
IKSRWARGLH DPSSSARITL AENVISFASH LNQFSRHKSS PLGVATALLL PLHRILEGPL
TEDTIPARRE VFKALRIIFR DHPTDFRSDE PPPVFELLQR GFMDKDRSVR VDAGRALAEL
VDLHAHAIDR GCRPNEAIFM KIGILLDSNV KDVVKETLLI TVGAIGCGAQ FELLGLVVFC
LITQLGQRNH ALKGLAYAQL LEIVKKQKKS PYALVSSYFS QVAPFVVCRK LTNPVLIFET
CRFISVHPRD FISATRFKTL PYLFANCEGK VIEDISKELD EKISVLFTSY PLEILTHTFL
LHGPGQTNGA LRFITQLLSE STGNNITVFS LVKSFVFQLV ATLLVVGTEN EERATLATDA
LRKVERTLAD ETRERALADV DLPAFLKTVM LGVVSHLNGM LQDYHGKKSF SLKKQILRGL
EALIIQIGPS VHGISLQVMA TLQTMLVPEL AEVTLTTWYT FLSTLEVDDV VPHIGATSAA
IVCAWSVLAP SARELAKKCL RHVVFDIPSN VRSDAGDILN EVVDFSHIPE LSEIHTQLQP
LRIRDPCMQL NKILDRCSSH NVTVAQMALA ELQNFMRNNH ASLIQNLAVG DAFDSSIGRI
HSTLFQIVSR HAGVDCIRGL AFECMGILGA VDPDRCEIKS NETRMVMRSN FEDDQEAVLF
AMHLIQDVLA GAYQSTSDIE YQTQLALTIQ ELLQYCKFTR DLVSSRSTIS VPMQVRNRWN
SFPKHVLEII TPLLDSRFKL PHNTLPQLPS PIYPHQKTYR EWLQLWTSYL ITKASGDTAQ
TIFGPFRWAV RNKDVGVSHH ILPHLVLNIL ASENEDDTSG ILQELLTVLH DQVALDSLST
PDKKFLSAQV VFMLLDHLSG FVRVQRQETT KKPEAKKSRV TLDVKRRQEQ LARVDSVLSS
IDHELMAKAA LQCRSYARSL MNFERQIVSM RERRPPPPGQ DFTPYYERLH EIYSHLDEPD
GMEGISTLIL SPSLEHQIRQ HESTGRWTSA QSCWEVRLQQ HPDNLDFHLG LLRCLRNLGH
YDTLRTHVQG VLVRNPGWES ALVDFQVESA WMIGAWDDVH RIAANEHHQG ASMVKARVLL
AMRAGNLSLI EENLTRARLV LGAPTAASGI SGYRRAYDAL VDLHMIHELE LIHEAVCNLP
PSSQGRKSAI VTLSQILSAR LDRTLPTFRV HESLLSMRRT AFSLSSVPRP SITSQIGQSW
LASAKIARKA GQWQTAYSAM LQAQHSSAPF SFMESAKLVR ARGEPLRALQ ELENSMHILG
LVDNSNTLDL TRDDEQSKRM KAKAQILLAR WMNESDRYEA SYVLKKFQTA TELAPEWESA
FYHLGQFQDQ SFRNLPSDDK SNRCSGLKMN LSTIQCFAAA VAFGNKFVYQ TIPRMLTLWL
DLGEYKKIAE NSNYERINAA IANSIDSVPV YKWFTAFPQI VSRVGHPNRL VYSVLSKLIL
SVIRGYPNQA LWFFAPVVNS TKTNRQQRGR TILNQLKNDP AHAGSDLPGL ITNLHAMIDE
LLQLCDYPVE EGRKTLSMKR DFPKLFQMRN HSILIPLQSS LTVNLPPVSS MNNRDKQHNV
FDPSPPTFQG RIFLQLKVTI VTGLHADFYD EIEIIHSLAR PRKIYVQGSD GTIYMFLGKP
KDDLRKDARL MDFNGIINKL LKTNSDSRRR QLHIRTYGVV TLNEECGFIQ WVPNTTAVRA
ELLKYYNGKN AFPSWLSEVT KRIKESTDKE AAELFVTKIL PQFPPVFHEW FVDTFPEPSV
WLASRLCYGR TMAVMSMVGF ILGLGDRHCE NILLDGITGD LVHVDFNCLF EKGKTLETPE
RVPFRLTQNL VDGLGVTGVE GVFRIACEIT MQILRDNQDP LMSVLDAFIH DPLVEWEDEA
RKQRRQVKDA TAAKHGSDLR QWAKTVLRPI ERKLKGLYSP ANLTERTYGG ITTRAGGQEE
REISISNLVQ MLIQEAVDSA NLGKMYPGWA PWH
//
