ID A0A1J9R613_9EURO Unreviewed; 1703 AA.
AC A0A1J9R613;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OJD23444.1};
GN ORFNames=ACJ73_05202 {ECO:0000313|EMBL:OJD23444.1};
OS Blastomyces percursus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=1658174 {ECO:0000313|EMBL:OJD23444.1, ECO:0000313|Proteomes:UP000242791};
RN [1] {ECO:0000313|EMBL:OJD23444.1, ECO:0000313|Proteomes:UP000242791}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EI222 {ECO:0000313|EMBL:OJD23444.1,
RC ECO:0000313|Proteomes:UP000242791};
RA Cuomo C.A., Schwartz I.S., Kenyon C., De Hoog G.S., Govender N.P.,
RA Botha A., Moreno L., De Vries M., Munoz J.F., Stielow J.B.;
RT "Emmonsia species relationships and genome sequence.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJD23444.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LGTZ01000792; OJD23444.1; -; Genomic_DNA.
DR STRING; 1658174.A0A1J9R613; -.
DR VEuPathDB; FungiDB:ACJ73_05202; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000242791; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000242791}.
FT DOMAIN 373..498
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1456..1699
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1151..1181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1011..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1048
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1703 AA; 188885 MW; 8DD3EC726CFBDD15 CRC64;
MESEFRHGEQ TPPTPVQSEG KTSGVSTAQA TNETRLKRTP NQILRSEKQS LGQPHTRLLQ
DGNLQNESAT TNRRQRTNSL RRVKNSSEVL RQRALKRSNT IDVTPEGIGN AVRGGREARH
FTVGNVGHNG KLYLRPTNQA RSQPLPVTKP STPSIKNYLR PETPTEDRWT RHSMWSNSQL
SELRPDIVRE DSNESKYDIS TTPDDQGSRR HSLDDIPSSD SRNRKELRIV IERPEHERPK
SAGQPPIPAI EVTIPHFRLG GFRFTPEGIP TLRSSAYTKT SVSEHFRSSM ATESDYGIMS
HVPQSLNQDS QTARTYSVVP PVYHQPKALS ELSTVAPVQS PVFYKLREPI EPSIFDFLVQ
IMDDLSVVRY VKGSNEISAA TPARIVAQIS SDTFMDYELV SDFFLTFRSY LSPSNLLSLL
LARLQWAINR PEDDGRIIRI RTFAALRHWI LNYFVDDFVV NRDLRVQFCQ KLNQIYENVR
SSSNNSASDL KILLDLKRCW NGRCSLYWDS PNFVNDTHPD DKVTPGGVAG SRDAGRLSRL
SGIRDPSHII ESQAAGVIPQ SPAFPMKVAD YKEGDVQFPH SHTHNFSTAS AQDLPPSSES
VKSIQAVSCS FPSKGQKRGS THSTRPKGPH PVLVASGPRS SHTSSDIPAT APMIPIWRRP
AHSHKRSGSF SDSVRDDRAP LPALNLDTQG QSLLQTLPYP ESIIRGNSYA PVDPSVPTIA
PPSPPLEASQ FDFLHQELSP KSDNSVKPAP GVKTFIGTIR RALNNRQSGN SSNPQAGHPS
PLPSLKGKTS ALPLNVGVGG DAYRERRTGP DARVPSRIDV LCDDALQCYR QVLMWESLNS
GPVPEAVAAG ELGKDGLPMS ADRLNPDSHV RFGFGLGRIP SQLTTGSKSI VIVDDTRPAI
PLMSGALQTF SNGHHHFQEP PLHNCEEAID ASSPISHPDT LVGVPGPSLE RYDVTSISTA
RDSWHSEDYV TFSDQRSSSV FRSGSKTPVR SESGSRLRRY ASYHHGIMNL RNQSSIDSTS
ETVSRGESSR ASREKLPTRM LRRRPGGDLR KIQNVHDLQP GPRARSFESR TSYTESMAQS
LLYLNSDGTA GNPPNEQREQ EEIIFPMERY SATGARPSQQ IRASFEAAVA GFAKIPDDGD
GGIESTLLKL EGKWERPSPN TPRDSQGQTS TGDILTDKHN DRKEEFYRDK YLAEPSILPT
YQPDNDRTLS ALTAPDTESF IGSEDSYCSI PLLERGLSDE SMKSPVFSPP ILVPQPLFNA
DYDPVSDKLE SSHPSIDMVE ETESLKRIPQ GSTAPRPPTL SSSLHKPNDD NVKGDDDHGY
GSEFSSEISV IDKDEGIDGY YGKRTVPGMD AALPGLGVIS HPLTHPPSPP MTARYHGSTS
SYAAPVDTVA FQRQPITPDL SPSCKNLSST TTQRTLDMQH LSSNVLLCSE AQTYARETPA
MIASNHHHLP FILACGSLVL AQQFTLVEKA ALNEADWKDL VDMRWSQPSQ STLNWAEYLS
QHDRRGIDIV VARFNLMVKW AVSEVVLTRN ISERAQTITK LIHIAVHSRR LRNYSTMLQI
TIALCSVDCT RLAKTWELVA DGEKRLLKDM ETLAQPIRNF QKLRLEMEST NLQDGCVPFV
GLYVQDLTYN SQKPAQIAST RDGEPLVNFE RYRTAATIVK SLLRLIDAST KYTFEPVYGV
IERCLWISAL PDEKIMALSK DLV
//
